Patents Represented by Law Firm DePaoli & Frenkel
  • Patent number: 6019104
    Abstract: A method for treating patients to inhibit restenosis associated with coronary intervention, which comprises administering compounds of the class of aminobenzoic acids, specifically 2-(3,4-dimethoxy-cinnamoyl)-aminobenzoic acid or its pharmaceutically acceptable salt at a dosage which is sufficient to maintain the plasma concentration at about 100.mu. molar for a period of time of less than three months.
    Type: Grant
    Filed: December 30, 1996
    Date of Patent: February 1, 2000
    Assignee: Kissei Pharmaceutical Co., Ltd.
    Inventors: Juichi Fukuyama, Keiji Miyazawa, Shuichiro Hamano, Arao Ujiie
  • Patent number: 5979048
    Abstract: A method of simultaneously manufacturing a plurality of connectors involves:molding a resin to form a connector member assembly containing multiple connector members, each member having one or two opposite longitudinally elongated through-holes extending between front and rear faces of the member along opposite sides thereof;forming a first metal coating on the front and rear faces and on an inner surface of each through-hole;providing metal-platable and non-metal-platable regions on each first-metal-coated front and rear face;forming a second metal coating on the metal-platable regions to form conductive patterns and on each first-metal-plated inner surface to form a conductive inner surface;removing the first metal coating from the non-metal-platable regions to form non-conductive patterns;then detaching each connector member from the connector assembly, each detached member having one or two side faces containing the metal-plated inner surface of the one or two through-holes; andremoving the first and seco
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: November 9, 1999
    Assignees: Polyplastics, Co., Inc., Sankyoukasei Co., Ltd
    Inventors: Yoshiaki Nishikawa, Tetsuo Yumoto
  • Patent number: 5958380
    Abstract: This invention relates to a stable, single-part chewing gum product and methods of using same to effect remineralization of subsurface lesions in teeth and/or mineralization of exposed dentinal tubules. The chewing gum product contains a water-soluble cationic portion, a water-soluble anionic portion and a stabilizing component which substantially inhibits reaction between the cationic and anionic portions during storage of the chewing gum product but which allows the cationic and anionic portions to be simultaneously released at a substantially equal rate from the product when the product is chewed in the presence of saliva and/or water. The cationic portion is composed of at least one water-soluble calcium salt, and the anionic portion contains at least one water-soluble phosphate and, optionally, at least one water-soluble fluoride salt.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: September 28, 1999
    Assignee: Enamelon, Inc.
    Inventors: Anthony E. Winston, Norman Usen
  • Patent number: 5954670
    Abstract: A biopsy guide device and method for obtaining multiple biopsies at a target area without having to withdraw the biopsy guide device from the target area and reinsert the device. The biopsy guide device contains at least one means for receiving a biopsy obtaining instrument and a means for guiding the biopsy guide device to the target area. The biopsy guide device is secured internally at the target area by a guide mandrel. The biopsy guide device can be rotated about the guide mandrel to obtain multiple biopsies of the target area.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: September 21, 1999
    Inventor: Gary H. Baker
  • Patent number: 5949579
    Abstract: A portable viewing tunnel for transparencies, medical radiographs, mammograms and other trans-illuminated materials is presented. Its proper use provokes human physiologic darkness adaptation primarily by means of an elastic neoprene rubber laminate cylinder with a malleable distal aperture which can be manually shaped to fit the form of the dark or detailed areas of interest being viewed. This characteristic prevents light which is emanating from bright sources within or next to the trans-illuminated image from reaching the eyes and spoiling physiologic darkness adaptation. Additional steps to exclude stray light include a soft, form fitting goggle on the proximal end to contact the face around the eyes forming a light tight junction between viewing tunnel and the eyes. An intermediate lens board is included for easy changes in binocular magnifier lenses. This device replaces most of the need for bright lighting or masking for viewing dark areas on transparencies and other trans-illuminated materials.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: September 7, 1999
    Inventor: Gary H. Baker
  • Patent number: 5895641
    Abstract: The present invention relates to the problems of remineralization without demineralization of dental enamel by applying to the teeth a composition which is present in two phases which do not react with one another until introduced into the oral cavity. One phase contains at least one water-soluble calcium compound and the other contains at least one water-soluble inorganic phosphate and at least one water-soluble fluorine compound. In this way the ions which effect remineralization can be absorbed by the dental enamel and their subsequent reaction causes rehardening of demineralized areas in the dental enamel.
    Type: Grant
    Filed: June 26, 1996
    Date of Patent: April 20, 1999
    Assignee: Enamelon
    Inventors: Norman Usen, Anthony E. Winston
  • Patent number: 5866102
    Abstract: This invention relates to non-aqueous compositions and methods utilizing same which are useful to remineralize subsurface dental enamel. More specifically, this invention relates to stable, single-part compositions containing calcium and phosphate salts which may be in a hydrophilic, non-aqueous vehicle and which when applied to lesions in dental enamel result in remineralization of subsurface dental enamel and/or mineralization of tubules in dentin thereby counteracting caries and/or hypersensitivity.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: February 2, 1999
    Assignee: Enamelon, Inc.
    Inventors: Anthony E. Winston, Norman Usen
  • Patent number: 5861437
    Abstract: A poly(phenylene ether) resin composed of structural units represented by the general formula: ##STR1## (wherein R.sup.1, R.sup.2 and R.sup.3 represent each alkyl, cycloalkyl, etc. or H (provided that two or more of R.sup.1, R.sup.2 and R.sup.3 do not represent H at the same time), or one of R.sup.1, R.sup.2 and R.sup.3 represents alkyl or H while the others together form a saturated ring, or R.sup.1, R.sup.2 and R.sup.3 together form an aromatic ring; A represents alkyl; p is an integer of from 3 to 5; and Y.sup.- represents a pharmaceutically acceptable acid residue) and/or structural units represented by the general formula: ##STR2## (wherein R.sup.4, R.sup.5 and R.sup.6 represents each alkyl, cycloalkyl, etc. or H (provided that two or more of R.sup.4, R.sup.5 and R.sup.6 do not represent H at the same time), or one of R.sup.4, R.sup.5 and R.sup.6 represents alkyl or H while the others together form a saturated ring, or R.sup.4, R.sup.5 and R.sup.6 together form an aromatic ring; and A, p and Y.sup.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: January 19, 1999
    Assignee: Kissei Pharmaceutical Company, Ltd.
    Inventors: Hiromu Harada, Yukihiko Hotei, Hideki Hujikura, Yoshinori Nonaka, Koji Kamata, Mitsuhiro Ichihara, Hiroshi Kusama, Humiyasu Satoh
  • Patent number: 5860565
    Abstract: A planar, partition-forming insert member, when disposed in a tube, e.g., a toothpaste tube, divides the tube into two compartments for storage of two components which are to be prevented from reacting until the product is ready for use. A dual-compartment assembly contains the two separate compartments in which the two components are stored until the compartments are opened for use. The assembly contains a dispensing tube and the planar partition-forming insert member disposed in the tube, the insert member causing the tube to be divided into the two compartments. The assembly is capable of separately storing the components in the two compartments and simultaneously dispensing the components from the two compartments.
    Type: Grant
    Filed: May 13, 1997
    Date of Patent: January 19, 1999
    Assignee: Enamelon, Inc.
    Inventors: Anthony E. Winston, Norman Usen, Linda J. Lancaster
  • Patent number: 5858329
    Abstract: A method of performing an NMR diagnostic procedure in a patient in need of the same comprising administering to the patient an effective amount of an NMR diagnostic medium and then exposing the patient to an NMR measurement step to which the diagnostic medium is responsive thereby imaging at least a portion of the patient's body, wherein the diagnostic medium comprises a composition of matter which contains a compound which has the structural formula: ##STR1## wherein R, R.sub.1 -R.sub.10 and M are defined herein.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: January 12, 1999
    Assignee: Hoechst Celanese Corporation
    Inventors: Wei-Jen Peng, Humberto Ramos, Jr.
  • Patent number: 5858333
    Abstract: A two-part oral product capable of remineralizing subsurface lesions and/or mineralizing exposed dentinal tubules in teeth is composed of cationic and anionic discrete parts. The cationic discrete part contains at least one water-soluble calcium salt and, preferably, at least one non-toxic, water-soluble salt of a divalent metal other than calcium, and a first pharmaceutically acceptable carrier. The anionic discrete part contains at least one water-soluble phosphate salt and, preferably, at least one water-soluble fluoride salt, and a second pharmaceutically carrier. Preferably, one of the carriers is an aqueous carrier and the other of the carriers is a non-aqueous carrier. The cationic and anionic parts are simultaneously released from the product upon mixing of the product with water and/or saliva to form the mixed aqueous solution. In this way, calcium ions released by the calcium salt and phosphate ions released by the phosphate salt are simultaneously delivered to the tooth surfaces by the solution.
    Type: Grant
    Filed: August 7, 1998
    Date of Patent: January 12, 1999
    Assignee: Enamelon, Inc.
    Inventors: Anthony E. Winston, Norman Usen
  • Patent number: 5833957
    Abstract: The present invention relates to remineralization, without demineralization, by applying to the teeth a composition which is present in either one or in two phases and which does not react to any large extent until introduced into the oral cavity and upon such introduction does not rapidly precipitate. One phase systems contain at least one water-soluble calcium compound, at least one other water-soluble, non-toxic compound containing a divalent metal different from calcium, and at least one water-soluble inorganic phosphate compound. If desired at least one water-soluble fluorine compound may be added to the system. In two phase systems one phase contains the calcium and the divalent metal compounds and the other the phosphate and optionally, the fluoride compound. In this way the ions which effect remineralization can be absorbed by the dental enamel and their subsequent, but controlled, reaction causes rehardening of demineralized areas in the dental enamel.
    Type: Grant
    Filed: August 27, 1997
    Date of Patent: November 10, 1998
    Assignee: Enamelon, Inc.
    Inventors: Anthony E. Winston, Norman Usen
  • Patent number: 5817296
    Abstract: The present invention relates to remineralization, without demineralization, by applying to the teeth a composition which is present in either one or in two phases and which does not react to any large extent until introduced into the oral cavity and upon such introduction does not rapidly precipitate. One phase systems contain at least one water-soluble calcium compound, at least one other water-soluble, non-toxic compound containing a divalent metal different from calcium, and at least one water-soluble inorganic phosphate compound. If desired at least one water-soluble fluorine compound may be added to the system. In two phase systems one phase contains the calcium and the divalent metal compounds and the other the phosphate and optionally, the fluoride compound. In this way the ions which effect remineralization can be absorbed by the dental enamel and their subsequent, but controlled, reaction causes rehardening of demineralized areas in the dental enamel.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: October 6, 1998
    Assignee: Enamelon, Inc.
    Inventors: Anthony E. Winston, Norman Usen
  • Patent number: 5810707
    Abstract: A dynamic table/shield apparatus contains a movable treatment table and at least one shielding block which is movable relative to the table. The apparatus effects total body irradiation treatment of a body disposed on the table while completely shielding, throughout the treatment time, a midplane of a predetermined body part from a radiation beam emitted from a radiation source during the treatment. During the treatment, the table and body are moved in a first direction at a first velocity V.sub.1 through a radiation field, and the shielding block is moved relative to the table at a second velocity V.sub.2 in a second direction opposite of the first direction. The second velocity is equal to (V.sub.1)(b/a), wherein "V.sub.1 " is the first velocity, "b" is the perpendicular distance between the the shielding block and the midplane of the body part, and "a" is the perpendicular distance between the midplane of the body part and the radiation source.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: September 22, 1998
    Assignee: Advanced Research & Technology Instiute
    Inventors: Joseph F. Montebello, Lech S. Papiez
  • Patent number: 5735458
    Abstract: A railway rail anchoring device, for use with a railway rail-fastening clip which is approximately M-shaped in plan and has first and second leg portions and a rail-bearing portion, comprises a base member and first and second clip-retaining members connected together by the base member such that the first clip-retaining member is spaced apart from the second clip-retaining member so as to define between the first and second clip-retaining members an opening for receiving the rail-bearing portion of such a clip.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: April 7, 1998
    Assignee: Pandrol Limited
    Inventors: Trevor P. Brown, Brian G. Conroy, Stephen J. Cox, Christopher Gardner, Roger D. Larke, Barry Marshall, Jan Svendsen
  • Patent number: 5705550
    Abstract: A polyarylene sulfide resin composition is improved in mold releasing characteristics in molding, is thermally and chemically stable, evolves little decomposition gases and exhibits excellent mechanical characteristics. The composition can be prepared by blending (A) 100 parts by weight of a polyarylene sulfide resin with (B) 0.01 to 5 parts by weight of an ester compound composed of a polybasic aliphatic carboxylic acid and a monohydric aliphatic alcohol.
    Type: Grant
    Filed: August 22, 1996
    Date of Patent: January 6, 1998
    Assignee: Polyplastics Co., Ltd.
    Inventor: Nozomu Nakagawa
  • Patent number: 5679976
    Abstract: The present invention provides a molded electric part which does not include any lead wires and is preferably compact in size and light in weight. The molded electric part of the invention can effectively prevent deterioration of an electric element by molding the element with a resin. The invention is also directed to a method of simultaneously manufacturing a number of products having fixed dimensions and excellent electrical properties through injection molding with a multi-forming mold complex. A molded film capacitor (1) of the invention includes a film capacitor element (2) and an element-receiving body (3) mainly composed of a synthetic resin with high dielectric ability. The film capacitor element (2) is accommodated in an element-receiving recess (7) formed in a substantial center of the element-receiving body (3).
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: October 21, 1997
    Assignee: Polyplastics Co., Ltd.
    Inventors: Yoshiaki Nishikawa, Yasuyuki Takeda, Masanaga Kikuzawa
  • Patent number: 5658537
    Abstract: A plate-type chemical reactor and method of using same to react two or more mutually separated fluid component streams are disclosed, wherein the reactor contains one or more reactor plates including at least one reaction-chamber reactor plate; at least one reaction chamber formed on a front facial surface of the reaction-chamber reactor plate(s); and at least one heat exchange channel passing through the reaction-chamber reactor plate(s) such that at least one section of heat exchange channel(s) is disposed in a heat exchange relationship with the reaction chamber(s); the reaction chamber containing: a plurality of inlet means for receiving and directing a plurality of mutually separated fluid component streams, a first mixing zone for mixing the separated fluid component streams to form a single at least partially reacted multicomponent fluid stream thereof, and at least one outlet means.
    Type: Grant
    Filed: July 18, 1995
    Date of Patent: August 19, 1997
    Assignee: BASF Corporation
    Inventor: Jeffrey S. Dugan
  • Patent number: 5645853
    Abstract: This invention relates to chewing gum compositions and methods utilizing same which are useful to remineralize subsurface dental enamel. More specifically, this invention relates to stable, single-part chewing gum compositions containing calcium and phosphate salts which when applied to lesions in dental enamel result in remineralization of subsurface dental enamel and/or mineralization of tubules in dentin thereby counteracting caries and/or hypersensitivity.
    Type: Grant
    Filed: August 8, 1995
    Date of Patent: July 8, 1997
    Assignee: Enamelon Inc.
    Inventors: Anthony E. Winston, Norman Usen
  • Patent number: RE36035
    Abstract: The present invention relates to plural compartment assemblies in which materials are stored in at least two separate compartments until the compartments are opened for use. More particularly, the invention relates to a dispensing tube whereby the utilization of a novel insert, a conventional dispensing tube can be divided into separate and discrete compartments at a low cost. The resulting dispensing assembly provides for dispensing more than one material from the same tube and even more particularly co-dispense predetermined proportions of incompatible materials simultaneously and effectively.
    Type: Grant
    Filed: November 7, 1997
    Date of Patent: January 12, 1999
    Assignee: Enamelon, Inc.
    Inventors: Norman Usen, Anthony E. Winston