Abstract: Novel 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts and their use as antimuscarinic agents having antisecretory activity selective for the gastrointestinal tract are disclosed. The compounds have the formula: ##STR1## wherein: X=H, halogen, lower alkyl, lower alkoxy, hydroxy, andR=morpholinyl, thiomorpholinyl, piperidinyl, 1,4-dioxa-8-azaspiro[4.5]decanyl, 4-(2,6-dimethylmorpholinyl), 4-ketopiperidinyl, 4-hydroxypiperidinyl, 4-substituted piperazinyl (wherein the substituent is lower alkyl, hydroxyalkyl, acetoxyalkyl, or acyl).Also disclosed are pharmaceutical compositions for treatment of irritable bowel syndrome and methods for using such compounds.
Type:
Grant
Filed:
May 17, 1988
Date of Patent:
June 27, 1989
Assignee:
Marion Laboratories, Inc.
Inventors:
Waclaw J. Rzeszotarski, Vicki H. Audia, Moshe Weitzberg
Abstract: A magnetic safety device, inter alia for a food processor, wherein, when a cover (10) is locked on a bowl (3), which in turn is locked to a base (1), a permanent magnet (12) is brought towards a magnetically controlled working contact (11) connected in series in the supply circuit of a motor (2).
Type:
Grant
Filed:
November 17, 1983
Date of Patent:
May 3, 1988
Assignee:
Robot-Coupe S.A.
Inventors:
Marcel Coggiola, Patrick Ribassin, Manuel Gallardo, Jean Meyer, Alain J. L. Bertin
Abstract: An assembly for use with a food processor and adapted to permit processing of large food items, the assembly including a tubular member mountable on the open end of the processor bowl and provided with an inwardly directed wall terminating in a boss.