Abstract: Compounds of the formula: are described, along with pharmaceutical compositions containing these compounds, and methods of using the compounds to prevent and to treat cancer in mammals, including humans.

Abstract: A pincer (e.g., a tweezer) has tips which are at least substantially transparent, such that a user can at least partially view an object being grasped through the tips, and/or such that the tips collect and channel incident light onto the grasped item. The tips preferably have an exterior which is convex in one or more dimensions, and are configured and/or coated such that light falling on the tip exteriors is focused onto a spot or band on the item. Since the tips can enhance illumination of an item being grasped, they can particularly enhance the viewing of translucent materials such as gemstones or selected biological materials.

Abstract: The present invention provides materials and methods that make liquid crystal phases accessible with relatively short ?-peptides in aqueous solvents.

Abstract: An implantable shock electrode line having a proximal terminal for connection to an implantable defibrillator, an elongated flexible line body, and a shock electrode and a drug delivery device arranged at or near the distal end of the line body. A drug depot connected to the drug delivery device is provided in the shock electrode line, and the terminal is designed as a purely electric standard terminal. The drug delivery device is designed for control by an electric pulse transmitted over the electric terminal to the shock electrode line.

Abstract: Disclosed are methods for detecting and treating joint disease. The methods of diagnosis include determining increased expression of enzymes that are upregulated during the progress of joint and ligament inflammation and degeneration. In addition, disclosed are methods of treating the disease including inhibiting the activity of responsible proteases.

Abstract: A light emitter to be attached to caps includes a case having several second lamps formed at a front surface thereof, a power switch attached to an outer surface of the case, a battery installed inside the case to provide power, a guide channel formed at a center of the case, a mounting clip formed at the outer surface of the case, a sub-body having a first lamp at a front surface thereof and being coupled to the guide channel, and a switch unit for controlling on/off operation of the first lamp. A user may move the sub-body back and forth to activate the first lamp, and may rotate the sub-body to alter the illumination angle of the first lamp.

Abstract: A hydraulically operated attachment for a skid loader or the like provides for the easy removal of large trees and the lifting of other heavy objects. The lift attachment includes a frame, a base portion extending forward from the bottom of the frame, a lifter portion hingedly attached to the top of the frame, and a hydraulic cylinder for moving the lifter portion from a down position to a raised position.

Abstract: A device for performing cell assays has at least one assay site. The site comprises a pair of stimulating electrodes and a cell confinement cavity for confining at least one cell in an extracellular fluid medium. The cell confinement cavity and the stimulating electrodes are arranged so that, in use, each cell is exposable to an electrical field generated by a potential difference applied across the stimulating electrodes. The stimulating electrodes are spaced a distance apart such that the potential difference can induce field stimulation of each cell and simultaneously be below the level that would result in electrolysis of the extracellular fluid medium.

Abstract: A roof system includes modular trays placed side-by-side on a roof, and a border along the boundaries of the system. The border includes side members with walls that extend from the roof to the top of the modules, along the length of the outer sides of the modules, to conceal the otherwise exposed sides of the modules. The side members include feet that extend along the roof line, from the base of the sidewalls to below the outer perimeter of the modules such that the weight of the trays holds the feet against the roof. The feet are formed with upward projections that are gravitationally engaged into voids formed in the bottoms of the modules to lock the side members in position at the sides of the modules.

Abstract: An equine training aid for enabling a horse, pony, donkey or the like, particularly dressage or show horses, to adopt an optimum outline or profile. The training aid includes a self-centering, continuous loop portion (1), configured, during lunging or riding, to be in contact tension with the equine wherein the continuous loop portion (1) includes a front section (1a) and a rear section (1b) each of which are linked by a linker such as the form of rings (2a) and pivotal clips (2b). Each of the loop sections (1a) and (1b) additionally has two adjustment mechanisms (e.g. sliders; (3)) to allow each loop section to be lengthened or shortened and both ends of the rear section (1b) terminate in a safety loop (4) which allows rotation of the device to a limited extent and prevents the rear section of the loop portion (1b) from slipping down the hind legs of the equine when the device is being dismantled and removed from the equine.

Abstract: A prepared substrate upon which light directed DNA synthesis is to occur is exposed to light via an inverse mask pattern to deprotect inactive regions of the substrate where the synthesis is not intended to occur. The deprotected sites are then capped to disable permanently the inactive areas, thereby forming an inverse capped substrate. Unwanted DNA synthesis in the inactive areas is thus prevented, resulting in purer quality DNA, even though such areas may be exposed to light due to diffraction, scattering and flare during subsequent DNA synthesis of the intended active areas of the substrate.

Abstract: Closed cell polyamide foams are prepared by subjecting a polyamide resin to inert gases at an elevated pressure and at a temperature above the softening point of the resin and reducing the pressure while the temperature is maintained above the softening point of the resin, resulting in expansion of the resin.

Abstract: Sleeves for different portable electronic devices (portable media players, wireless telephones, handheld computers, etc.) adapt the outer contours of the devices such that all can fit within the pocket of a standard device dock. Each sleeve situates its portable electronic device within the pocket of the dock such that at least one of its power/communications ports is situated at a standard location. The device dock then also accommodates a connector which fits within the dock pocket, and which has power/communications ports situated at the standard location, such that when the sleeved device is inserted into the pocket, its power/communications ports interface with the power/communications ports of the connector. The connector can incorporate data storage devices, power supplies, interface cables extending to other devices (such as personal computers, stereo systems, etc.) such that it lends the functionality of these devices to the sleeved device situated within the pocket.

Abstract: A device for facilitating the movement of a vehicle across ground comprises a track able to move around a board. The device includes a track for contacting ground that is mounted on a board. Brackets are provided for attaching the board to a vehicle. The track is movable in a direction independent of the direction of movement of the vehicle in at least the reverse direction relative to the vehicle's direction of movement. That track is able to move around the board by means of cylinders arranged in the form of a belt extending around the board between the board and the track. The device can be used to facilitate movement of off-road vehicles across obstacles. It can also be used to provide snow-free sledges and skis. It is also envisaged that the device may be incorporated into a trolley, which can be used on uneven surfaces.

Abstract: A device and technique for a sutureless wound closure, which limits the risks of rupture and scarring, is described. The device includes a one-piece surgical fastener generally shaped in a curve along the width of the surgical fastener. The fastener includes a tissue insertion tongue with a plurality of tissue attachment points for fixing the fastener to skin tissue. The fastener also includes a clasp for engaging an identical surgical fastener. The surgical fastener can also be a two-piece structure including a male connecting strap and a female connector. Both pieces include a tissue-connecting mechanism for fixing to skin tissue. The female connector includes an engagement clasp for securing the male connecting strap to the female connector.

Abstract: Analogs of 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-napthalenyl)-1-propenyl]benzoic acid and methods of manufacture and use thereof, such as for use in cancer prevention and treatment.

Abstract: The invention is a selective growth medium for investigating, isolating, counting and directly identifying pathogenic bacteria of the genus Listeria.The medium promotes the Listeria spp. while simultaneously inhibiting the growth of non-Listeria organisms. The medium does not produce a bacterial biomass contaminated with interfering fluorophores. The medium contains nitrofurantoin, esculin and lithium chloride and lacks acriflavin.

Abstract: A method for converting levulinic acid to methyl vinyl ketone is described. The method includes the steps of reacting an aqueous solution of levulinic acid, over an acid catalyst, at a temperature of from room temperature to about 1100 K. Methyl vinyl ketone is thereby formed.