Patents Represented by Attorney Diana K. Sheiness
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Patent number: 6884598Abstract: The present invention provides methods for screening for a molecule that antagonizes or agonizes RANK activity. One aspect of the invention involves the growth of RANK responsive cells in semi-solid medium, wherein exposure to a RANK antagonist promotes colony formation. Other aspects of the invention rely on promoter/reporter constructs using RANK responsive promoters derived from the MMP-9 and TRAP genes. Additional aspects of the invention exploit the ability of RANK to activate c-src activity, F-actin ring formation and CaPO4 resorption.Type: GrantFiled: September 20, 2001Date of Patent: April 26, 2005Assignee: Immunex CorporationInventor: William C. Dougall
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Patent number: 6838262Abstract: Isolated ligands, DNAs encoding such ligands, and pharmaceutical compositions made therefrom, are disclosed. The isolated ligands can be used to regulate an immune response. The ligands are also useful in screening for inhibitors thereof.Type: GrantFiled: October 13, 2000Date of Patent: January 4, 2005Assignee: Immunex CorporationInventors: Dirk M. Anderson, Laurent J. Galibert
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Patent number: 6740522Abstract: Provided herein are antibodies that bind human RANKL polypeptides.Type: GrantFiled: May 25, 2001Date of Patent: May 25, 2004Assignee: Immunex CorporationInventor: Dirk M. Anderson
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Patent number: 6649164Abstract: Isolated ligands, DNAs encoding such ligands, and pharmaceutical compositions made therefrom, are disclosed. The isolated ligands can be used to enhance the functional capacity of dendritic cells.Type: GrantFiled: June 8, 2001Date of Patent: November 18, 2003Assignee: Immunex CorporationInventor: Eugene Maraskovsky
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Patent number: 6562948Abstract: Provided herein are isolated antibodies that specifically bind a RANK polypeptide.Type: GrantFiled: May 30, 2001Date of Patent: May 13, 2003Assignee: Immunex CorporationInventor: Dirk M. Anderson
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Patent number: 6537763Abstract: Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.Type: GrantFiled: May 31, 2001Date of Patent: March 25, 2003Assignee: Immunex CorporationInventors: William C. Dougall, Dirk M. Anderson, Laurent Galibert, Eugene Maraskovsky
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Patent number: 6528482Abstract: Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.Type: GrantFiled: December 17, 1999Date of Patent: March 4, 2003Assignee: Immunex CorporationInventors: Dirk M. Anderson, Laurent Galibert, Eugene Maraskovsky, William C. Dougall
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Patent number: 6448035Abstract: A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridize to oligonucleotide probes having defined sequences, processes for producing polypeptides of the LIR family, and antagonistic antibodies to LIR family members. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.Type: GrantFiled: April 24, 1997Date of Patent: September 10, 2002Assignee: Immunex CorporationInventor: David J. Cosman
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Patent number: 6419929Abstract: Isolated recombinant RANK-L polypeptide DNAs encoding RANK-L polypeptide, and pharmaceutical compositions made therefrom, are disclosed. The isolated RANK-L polypeptide can be used to regulate an immune response. The RANK-L polypeptide is also useful in screening for inhibitors thereof.Type: GrantFiled: May 24, 2000Date of Patent: July 16, 2002Assignee: Immunex CorporationInventor: Dirk M. Anderson
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Patent number: 6384203Abstract: A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridizes to defined nucleotide sequences, processes for producing polypeptides of the LIR family, and specific antibodies directed against LIR polypeptides. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.Type: GrantFiled: May 12, 1999Date of Patent: May 7, 2002Assignee: Immunex CorporationInventors: Dirk M. Anderson, Luis G. Borges
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Patent number: 6309632Abstract: Provided are methods for reducing the HIV viral load in HIV-infected patients by administering human GM-CSF. The GM-CSF is administered in conjunction with at least two nucleoside reverse transcriptase inhibitors.Type: GrantFiled: April 28, 1998Date of Patent: October 30, 2001Assignee: Immunex CorporationInventor: Jan M. Agosti
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Patent number: 6274175Abstract: Formulations for controlled, prolonged release of GM-CSF have been developed. These are based on solid microparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof with excipients and drug loadings that yield zero order or first order release, or multiphasic release over a period of approximately three to twenty one days, preferably one week, when administered by injection. In the preferred embodiment, the microparticles are microspheres having diameters in the range of 10 to 60 microns, formed of a blend of PLGA having different molecular weights, most preferably 6,000, 30,000 and 41,000. Other embodiments have been developed to alter the release kinetics or the manner in which the drug is distributed in vivo.Type: GrantFiled: November 17, 1999Date of Patent: August 14, 2001Assignee: Immunex CorporationInventors: Wayne R. Gombotz, Dean K. Pettit, Susan C. Pankey
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Patent number: 6271349Abstract: Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.Type: GrantFiled: December 17, 1998Date of Patent: August 7, 2001Assignee: Immunex CorporationInventors: William C. Dougall, Laurent Galibert
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Patent number: 6242213Abstract: Isolated ligands, DNAs encoding such ligands, and pharmaceutical compositions made therefrom, are disclosed. The isolated ligands can be used to regulate an immune response. The ligands are also useful in screening for inhibitors thereof.Type: GrantFiled: December 22, 1997Date of Patent: June 5, 2001Assignee: Immunex CorporationInventor: Dirk M. Anderson