Patents Represented by Attorney, Agent or Law Firm Diane Tso
  • Mammary gland chemokine
    Patent number: 6833241
    Abstract: The present invention provides various methods for utilizing a polypeptide encoding a chemokine (MEC) and a polypeptide translated therefrom. The MEC chemokine is underexpressed in tumors, making the chemokine a useful marker for diagnosis and prognosis of adverse bodily reactions.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: December 21, 2004
    Assignee: Novartis
    Inventors: Mark A. Labow, Craig Stephen Mickanin, Umesh Bhatia
  • Human heparanase polypeptide and cDNA
    Patent number: 6461848
    Abstract: This invention relates to identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, a polypeptide of the present invention is “heparanase”obtainable from the human SV40-transformed fibroblast cell line ATCC CCL 75.1. The heparanase is an endoglucuronidase capable of specifically degrading heparan sulfate into 6 to 20 kDa fragments.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: October 8, 2002
    Assignee: Novartis AG
    Inventors: Motowo Nakajima, Minako Funakubo
  • Synergistic combination therapy using benazepril and amlodipine for the treatment of cardiovascular disorders and compositions therefor
    Patent number: 6162802
    Abstract: A method for the treatment of a variety of cardiovascular disorders and related conditions in a mammal having at least one such disorder or condition is disclosed comprising treating the mammal with cotherapy comprising benazepril and amlodipine or pharmaceutically acceptable salts of either or both. Combination formulations of benazepril and amlodipine for use in the method are also disclosed.
    Type: Grant
    Filed: March 10, 1992
    Date of Patent: December 19, 2000
    Inventors: Joseph Papa, Marc M. J. Henis