Patents Represented by Attorney, Agent or Law Firm Dianne E. Reed
  • Patent number: 7067701
    Abstract: This invention relates to processes for making phosphorus compounds R2P—X—PR2, R2P-M, R2P-L and R3P, and the novel cation R2P+(L)-X—P+(L)R2, where R represents an optionally substituted hydrocarbyl group, X represents a bridging group, L represents a leaving group and M represents an alkali metal atom. The invention relates further to a process for making a compound R2P-L from a compound R—H via a new process for making the compound R—Li followed by its reaction with a compound Hal2P-L. The compound R2P—X—PR2 is a ligand suitable for making catalysts for copolymerizing carbon monoxide and a olefinically unsaturated compound.
    Type: Grant
    Filed: January 15, 2004
    Date of Patent: June 27, 2006
    Assignee: SRI International
    Inventors: Roelof Van Ginkel, Alexander Van Der Made, Jan De With, Ursula Eilenberg-Robben, legal representative, Wolf Eilenberg, deceased
  • Patent number: 6841676
    Abstract: Novel compounds are provided which are useful as catalysts, particularly in the polymerization of addition polymerizable monomers such as olefinic or vinyl monomers. The compounds are complexes of a mid-transition metal coordinated to at least two ligands, at least one of which is an unsaturated nitrogenous ligand. Depending on ligand substitution, stereospecific catalysts can be provided, including isospecific catalysts and syndiospecific catalysts. Catalyst systems containing the novel compounds in combination with a catalyst activator are provided as well, as are methods of using the novel compounds in the preparation of polyolefins.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: January 11, 2005
    Assignee: SRI International
    Inventors: Christopher D. Tagge, Robert B. Wilson, Jr.
  • Patent number: 6835392
    Abstract: A permeation enhancer composition is provided for increasing the permeability of skin or mucosal tissue to topically or transdermally administered pharmacologically or cosmeceutically active agents. The composition is comprised of a hydroxide-releasing agent and a lipophilic co-enhancer such as a fatty alcohol, a fatty ether, or a fatty acid ester, including fatty acid esters of polyols such as propylene glycol and glycerol. Also provided are pharmaceutical formulations containing a therapeutically effective amount of an active agent in addition to the aforementioned enhancer composition, methods for administering active agents topically or transdermally with enhanced permeation, and drug delivery systems for application to an individual's skin or mucosal tissue, wherein the systems are formulated so as to contain an active agent to be administered and an effective permeation enhancing amount of an enhancer composition of the invention.
    Type: Grant
    Filed: March 13, 2003
    Date of Patent: December 28, 2004
    Assignee: Dermatrends, Inc.
    Inventors: Tsung-Min Hsu, Eric C. Jacobson, Rose C. LoBello, Eric C. Luo
  • Patent number: 6833408
    Abstract: A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Kits for use in carrying out the method of the invention are also provided, as are pretreated surgically acceptable patches that have been coated with the aforementioned adhesive composition.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: December 21, 2004
    Assignee: Cohesion Technologies, Inc.
    Inventors: Louis C. Sehl, Olof Mikael Trollsas, Donald G. Wallace, David Toman, Frank A. DeLustro, Jacqueline A. Schroeder, George H. Chu
  • Patent number: 6821523
    Abstract: Provided are methods and topical pharmaceutical formulations for use in the treatment of warts. The invention involves the topical administration of a pharmacologically active base in a formulation having a pH of about 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations can be used to treat human papilloma virus infections, particularly cutaneous warts.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: November 23, 2004
    Assignee: Dermatrends, Inc.
    Inventors: Howard I. Maibach, Eric C. Luo, Tsung-Min Hsu
  • Patent number: 6815064
    Abstract: Methods for synthesizing luminescent nanoparticles and nanoparticles prepared by such methods are provided. The nanoparticles are prepared by a method in which an additive is included in the reaction mixture. The additive may be a Group 2 element, a Group 12 element, a Group 13 element, a Group 14 element, a Group 15 clement, or a Group 16 element. In additions, a luminescent nanoparticle is provided that comprises a semiconductive core surrounded by an inorganic shell, an interfacial region and an additive present in the interfacial region or both the interfacial region and the shell.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: November 9, 2004
    Assignee: Quantum Dot Corporation
    Inventors: Joseph A. Treadway, Donald A. Zehnder, Marc D. Schrier
  • Patent number: 6808934
    Abstract: The present invention provides a method for the acoustic ejection of fluid droplets from fluid-containing reservoirs to form arrays suitable for high-throughput combinatorial crystallization experiments. Such arrays may utilize very small fluid volumes, in the order of picoliters. The method is especially suited to preparing combinatorial libraries useful in developing techniques for crystallizing biomacromolecules, such as proteins. The small volumes conserve macromolecules that may be costly and rare, and permit the testing of a large number of experimental crystallization conditions for a given amount of a macromolecule. The time required for the experiments may be very short due to the small volumes. The invention is conducive to forming high-density microarrays of small volume crystallization experiments. Acoustic detection of crystals in situ, and distinction between biomacromolecular and non-biomacromolecular crystals, are also taught.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: October 26, 2004
    Assignee: Picoliter Inc.
    Inventors: Mitchell W. Mutz, Richard N. Ellson, Richard G. Stearns
  • Patent number: 6806325
    Abstract: Ruthenium and osmium carbene compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic olefins are disclosed. Also disclosed are methods of making the carbene compounds. The carbene compounds are of the formula where M is Os or Ru; R1 is hydrogen; R is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted aryl; X and X1 are independently selected from any anionic ligand; and L and L1 are independently selected from any neutral electron donor. The ruthenium and osmium carbene compounds of the present invention may be synthesized using diazo compounds, by neutral electron donor ligand exchange, by cross metathesis, using acetylene, using cumulated olefins, and in a one-pot method using diazo compounds and neutral electron donors.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: October 19, 2004
    Assignee: California Institute of Technology
    Inventors: Robert H. Grubbs, Peter Schwab, Sonbinh T. Nguyen
  • Patent number: 6806051
    Abstract: Partially nonhybridizing oligonucleotides are provided that contain two or more hybridizing segments, with any two hybridizing segments separated by a nonhybridizing spacer segment, i.e., a nucleotidic or nonnucleotidic segment that has little or no likelihood of binding to an oligonucleotide sequence found in nature. Oligonucleotide arrays are also provided in which at least one of the oligonucleotides of the array is a partially nonhybridizing oligonucleotide. The partially nonhybridizing oligonucleotides serve as multifunctional probes wherein each hybridizing segment of a single partially nonhybridizing oligonucleotide serves as an individual probe. Also provided are methods for preparing and using the partially nonhybridizing oligonucleotides and arrays formed therewith. A particularly preferred method of array fabrication involves the use of focused acoustic energy.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: October 19, 2004
    Assignee: Picoliter Inc.
    Inventor: Richard N. Ellson
  • Patent number: 6802593
    Abstract: The present invention provides a method and device for the acoustic ejection of fluid droplets from each of a plurality of fluid-containing reservoirs. The droplets are ejected toward sites on a substrate surface for deposition thereon. The device is comprised of: a plurality of reservoirs each adapted to contain a fluid; an ejector comprising a means for generating acoustic radiation and a means for focusing the generated acoustic radiation so as to eject fluid droplets from the reservoir fluids; and a means for positioning the ejector in acoustically coupled relationship to each of the reservoirs. The invention is useful in a number of contexts, particularly in the preparation of biomolecular arrays.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: October 12, 2004
    Assignee: Picoliter Inc.
    Inventors: Richard N. Ellson, James K. Foote, Mitchell W. Mutz
  • Patent number: 6803429
    Abstract: A catalytic method is provided for a ring-opening cross-metathesis reaction between a cycloolefinic substrate and a second olefinic reactant, wherein the catalyst used is a transition metal alkylidene complex substituted with an N-heterocyclic carbene ligand. The substrates are selected so that the rate of the cross-metathesis reaction of the second olefinic reactant, kCM, is greater than or equal to the rate of the ring-opening metathesis reaction, kRO. In this way, the predominant ROCM product is a monomer, dimer, and/or oligomer, but not a polymer. The invention additionally provides for selective production of an end-differentiated olefinic product, using trisubstituted cycloolefins as substrates and/or a subsequent cross-metathesis reaction following an initial ROCM step. The cycloolefinic substrates include low-strain olefins such as cyclohexene as well as higher strain olefins such as cyclooctene.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: October 12, 2004
    Assignee: California Institute of Technology
    Inventors: John P. Morgan, Christie Morrill, Robert H. Grubbs, Tae-Lim Choi
  • Patent number: 6803420
    Abstract: An adhesive composition is provided that contains both a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase is composed of a crosslinked hydrophobic polymer composition and the hydrophilic phase is a water-absorbent blend of a hydrophilic polymer and a complementary oligomer capable of crosslinking the hydrophilic polymer through hydrogen bonding, ionic bonding, and/or covalent bonding. The composition is useful as a bioadhesive, for affixing drug delivery systems, wound dressings, bandages, cushions, or the like to a body surface such as skin or mucosal tissue.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: October 12, 2004
    Assignees: Corium International, A.V. Topchiev Institute of Petrochemical Synthsis, Russian Academy of Sciences
    Inventors: Gary W. Cleary, Mikhail M. Feldstein, Valery G. Kulichikhin, Danir F. Bairamov
  • Patent number: 6800722
    Abstract: The invention provides conjugated polymers that have good solubility and semiconductivity, and that display high photoluminescent and electroluminescent efficiency.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: October 5, 2004
    Assignee: SRI International
    Inventor: Qibing Pei
  • Patent number: 6800655
    Abstract: Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of indole-3-carbinol metabolites wherein the structures and substituents of the compounds are selected to enhance the compounds' overall efficacy, particularly with respect to therapeutic activity, oral bioavailability, long-term safety, patient tolerability, and therapeutic window. The compounds are useful not only in treatment of cancer but also in prevention of cancer. One preferred class of the novel compounds have the structure of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are defined herein. Pharmaceutical compositions are provided as well, as are methods of synthesis and use.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: October 5, 2004
    Assignee: Sri International
    Inventors: Ling Jong, Wan-Ru Chao
  • Patent number: 6794110
    Abstract: A polymer blend is provided for use in a lithographic photoresist composition, particularly a chemical amplification photoresist. In a preferred embodiment, the polymer blend is substantially transparent to deep ultraviolet radiation, i.e., radiation of a wavelength less than 250 nm, including wavelengths of 157 nm, 193 nm and 248 nm, and has improved sensitivity and resolution. Processes for preparing and using the polymer blend are also provided, as are lithographic photoresist compositions that contain the polymer blend.
    Type: Grant
    Filed: March 4, 2002
    Date of Patent: September 21, 2004
    Assignee: International Business Machines Corporation
    Inventors: Gregory Breyta, Hiroshi Ito, Hoa D. Truong
  • Patent number: 6784170
    Abstract: Syntheses of steroids such as 3-hydroxy-7&agr;-methyl-21-[2′-methoxy-4′-(diethylaminomethyl)-phenoxy]-19-norpregna-1,3,5(10)triene citrate (“SR 16234”) and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serves as a starting material or intermediate. The latter compound may be readily prepared from estrone-3-methyl ether. Certain intermediates in these syntheses also have value as therapeutic agents, for example in the treatment of prostate disorders such as prostatic cancer.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: August 31, 2004
    Assignee: SRI International
    Inventors: Richard H. Peters, Jyanwei Liu, John G. Johansson, Kenneth J. Ryan, Wan-Ru Chao, Masato Tanabe
  • Patent number: 6784323
    Abstract: Nonmetallic organic catalysts are provided that facilitate the enantioselective reaction of &agr;,&bgr;-unsaturated aldehydes. The catalysts are chiral imidazolidinone compounds having the structure of formula (IIA) or (IIB) or are acid addition salts thereof, wherein, in one preferred embodiment, R1 is C1-C6 alkyl, R2 is tri(C1-C6 alkyl)-substituted methyl, R3 and R4 are hydrogen, and R5 is phenyl optionally substituted with 1 or 2 substituents selected from the group consisting of halo, hydroxyl, and C1-C6 alkyl. The chiral imidazolidinones are useful in catalyzing a wide variety of reactions, including cycloaddition reactions, Friedel-Crafts alkylation reactions, and Michael additions.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: August 31, 2004
    Assignee: California Institute of Technology
    Inventor: David W. C. MacMillan
  • Patent number: 6780492
    Abstract: A method is disclosed for providing a patterned surface wherein predetermined regions of the surface are masked with a self-assembled monolayer (“SAM”) covalently bound to a brush polymer overlayer. The remainder of the substrate surface will generally be functionalized with a second self-assembled monolayer. Preferably, the method involves a microcontact printing technique, wherein a molecular moiety capable of spontaneously forming an SAM upon transfer to a surface is “stamped” onto a substrate surface, followed by growth (or covalent attachment) of a polymer on exposed functional groups within the SAM molecules. Coverage of surface regions with both an SAM and a polymer overlayer provides a number of advantages, particularly with regard to surface masking during etching and the like. The method is useful in the manufacture of microelectronic circuitry, biosensors, high-density assay plates, and the like.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: August 24, 2004
    Assignees: International Business Machines Corporation, The Regents of the University of California
    Inventors: Craig Jon Hawker, James Lupton Hedrick, Nicholas Abbott
  • Patent number: 6761977
    Abstract: Compositions and methods are provided for improving the quality of images printed on a substrate. The novel image-enhancing compositions contain as an image-enhancing agent (a) an azetidinium polymer, (b) a guanidine polymer, (c) a mixture of an azetidinium polymer and a guanidine polymer, or (d) a copolymer of an azetidinium monomer and a guanidine monomer. When applied to a substrate, the compositions provide for high quality printed images when the treated substrate is printed on with an ink containing a reactive dye capable of reacting with the image-enhancing agent. Images printed on a substrate treated with the image-enhancing compositions of the invention are water-resistant (e.g., water-fast), bleed-resistant, rub-resistant, and/or are characterized by an enhanced chroma and hue.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: July 13, 2004
    Inventor: Asutosh Nigam
  • Patent number: RE38676
    Abstract: The present invention generally relates to the use of certain ruthenium and osmium complexes that are substantially inactive at a first temperature (preferably about room temperature) but becomes progressively more active at a higher second temperature. This difference in reactivities allows the reaction mixture to be formed and manipulated at the first temperature until polymerization is desired. When appropriate, the reaction mixture is heated to a suitable temperature (preferably greater than 50° C.) to activate the catalyst and to initiate polymerization. Because both the initiation and the rate of polymerization may be controlled with temperature, the inventive methods are especially suitable for ring opening metathesis polymerization (“ROMP”) reactions and for molding polymer articles that require extended pot-lives.
    Type: Grant
    Filed: August 21, 2002
    Date of Patent: December 21, 2004
    Assignee: California Institute of Technology
    Inventors: Robert H. Grubbs, Thomas E. Wilhelm