Patents Represented by Attorney, Agent or Law Firm Dianne E. Reed
  • Patent number: 6083936
    Abstract: Boron heterocycle steroid mimics are provided that are useful as pharmaceutical agents, particularly in the treatment of estrogen-dependent disorders such as estrogen-dependent cancers. The compounds are also useful in diagnostic techniques such as magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), in boron neutron capture therapy, and in fluorescence emission-based modalities. Pharmaceutical formulations and methods of using the novel compounds are provided as well.
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: July 4, 2000
    Assignee: SRI International
    Inventor: Michael P. Groziak
  • Patent number: 6083940
    Abstract: Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R.sup.1 through R.sup.10, a and b are as defined herein. Pharmaceutical compositions and methods for using the compounds of formula (I) to treat androgen-related clinical conditions are provided, as are methods and compositions for using the compounds as contraceptive agents.
    Type: Grant
    Filed: October 23, 1998
    Date of Patent: July 4, 2000
    Assignee: SRI International
    Inventors: Masato Tanabe, Wan-Ru Chao, Wesley K. M. Chong, David F. Crowe
  • Patent number: 6071237
    Abstract: A device and method are provided for assessing impairment of blood circulation in a patient, such as that in perfusion failure, wherein the patient requires mechanical ventilatory support. The invention involves measurement of PCO.sub.2 (partial pressure of carbon dioxide) within the lower respiratory tract of the patient, using a device that includes an endotracheal breathing tube for introducing air from an air supply pump into a patient's lungs, wherein a carbon dioxide sensor is provided as an integral part of that device, i.e., is physically connected to the endotracheal breathing tube in a manner that allows for PCO.sub.2 measurement along the sidewall of the patient's trachea.
    Type: Grant
    Filed: February 19, 1999
    Date of Patent: June 6, 2000
    Assignee: Institute of Critical Care Medicine
    Inventors: Max Harry Weil, Wanchun Tang, Jose Bisera
  • Patent number: 6072014
    Abstract: A process is provided for preparing polymer compositions which are multimodal in nature. The process involves contacting, under polymerization conditions, a selected addition polymerizable monomer with a metallocene catalyst having two or more distinct and chemically different active sites, and a catalyst activator.
    Type: Grant
    Filed: August 11, 1999
    Date of Patent: June 6, 2000
    Assignee: SRI International
    Inventor: Robert B. Wilson, Jr.
  • Patent number: 6061115
    Abstract: Methods for producing a multi-domain alignment layer, as well as the multi-domain alignment layers produced thereby and liquid crystal displays comprising the same, are provided. In the subject methods, a surface of an alignment film, usually present on a substrate such a planar component of a polarized material, is bombarded with ions initially at normal incidence in the presence of an electric field in a manner sufficient such that the ions contact the surface of the alignment film at non-normal incidence. In a preferred embodiment, the electric field is produced by an array of conducting means associated with the surface of the alignment film, at least two of which means are differentially biased, e.g. alternately biased. The resultant alignment layers find use in liquid crystal display devices.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: May 9, 2000
    Assignee: International Business Machines Incorporation
    Inventors: Mahesh Govind Samant, Joachim Stohr
  • Patent number: 6055447
    Abstract: A method and apparatus are provided for assessing impairment of blood circulation of a patient by measurement of PCO.sub.2 (partial pressure of carbon dioxide) in the upper digestive/respiratory tract of the patient. The method includes introducing a CO.sub.2 sensor into the mouth-nose area and against a mucosal surface. In one example, the sensor is placed under the tongue, in the manner of an oral thermometer, and sublingual (under the tongue) measurements of CO.sub.2 are taken. This allows for the triage of patients or victims in emergency of disaster settings. The measurement involves minimal invasion while avoiding false readings. For monitoring of more than about one or two minutes, holders are used to hold the CO.sub.2 sensor instrument stabily in the mouth or nose, and to isolate the mucosal area immediately around the CO.sub.2 sensor from air flow that could carry away CO.sub.2, while maintaining high humidity.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: April 25, 2000
    Assignee: Institute of Critical Care Medicine
    Inventors: Max Harry Weil, Wanchun Tang, Jose Bisera
  • Patent number: 6054446
    Abstract: Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependent disorders. Preferred compounds have a 1,3,5-estratriene nucleus, and are substituted at the C-17 or C-11 position with a molecular moiety which renders the compounds effective to competitively block the binding of estrogen to its receptor. Particularly preferred compounds are 17-desoxy-1,3,5-estratrienes. Therapeutic methods and pharmaceutical compositions are provided as well.
    Type: Grant
    Filed: December 24, 1997
    Date of Patent: April 25, 2000
    Assignee: SRI International
    Inventors: Masato Tanabe, Richard H. Peters, Wan-Ru Chao, Ling Jong
  • Patent number: 6048992
    Abstract: A method is provided for synthesizing metallocene compounds useful as polymerization catalysts and the like. The method involves (a) preparation of an amino alcohol-derived ligand by reacting a silane reactant with an amino alcohol in the presence of base, followed by (b) metallation of the ligand so provided. The metallocenes may be provided in chiral form when the amino alcohol contains an asymmetric center, and are thus useful in catalyzing stereospecific polymerization and other stereospecific bond formation reactions.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: April 11, 2000
    Assignee: SRI International
    Inventors: Robert B. Wilson, Jr., Gary A. Koolpe
  • Patent number: 6048851
    Abstract: The subjects of this invention are pharmaceutical compositions that comprise gallium complexes of 3-hydroxy-4-pyrones. The compositions have been developed to provide pharmaceutically acceptable gallium bioavailability together with low toxicity, particularly for oral administration. Compositions included in this invention should be useful in providing gallium to humans and other animals for a wide variety of medical and veterinary applications, including the treatment, prevention, or diagnosis of certain bone diseases, certain cancers, and certain disorders of calcium homeostasis.
    Type: Grant
    Filed: January 29, 1998
    Date of Patent: April 11, 2000
    Inventor: Lawrence Richard Bernstein
  • Patent number: 6046186
    Abstract: Novel compounds useful as inhibitors of estrone sulfatase are provided. The compounds have the structural formula (I) wherein r1 is an optional double bond, R.sup.1 and R.sup.2 are selected from the group consisting of hydrogen and lower alky, or together form a cyclic substituent (II) ##STR1## wherein Q is NH, O or CH.sub.2, and the other various substituents are as defined herein. Pharmaceutical compositions and methods for using the compounds of formula (I) to treat estrogen-dependent disorders are provided as well.
    Type: Grant
    Filed: December 24, 1997
    Date of Patent: April 4, 2000
    Assignee: SRI International
    Inventors: Masato Tanabe, Richard H. Peters, Wan-Ru Chao, Kazuhiko Shigeno
  • Patent number: 6037346
    Abstract: A method is provided for treating erectile dysfunction in a mammalian male individual. The method involves the local administration of a phosphodiesterase inhibitor or a pharmaceutically acceptable salt, ester, amide or derivative thereof within the context of an effective dosing regimen. A preferred mode of administration is transurethral. Pharmaceutical formulations and kits are provided as well.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: March 14, 2000
    Assignee: Vivus, Inc.
    Inventors: Paul C. Doherty, Jr., Virgil A. Place, William L. Smith
  • Patent number: 6037360
    Abstract: A method is provided for delaying the onset of ejaculation in an individual. The method involves administration of a 5-HT.sub.3 receptor antagonist within the context of an effective dosing regimen. The preferred mode of administration is transurethral; however, the selected inhibitor may also be delivered via intracavernosal injection or using alternative routes.
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: March 14, 2000
    Assignee: Vivus, Incorporated
    Inventors: William L. Smith, Paul C. Doherty, Jr., Virgil A. Place
  • Patent number: 6022901
    Abstract: A method for preventing or treating restenosis and for preventing the recurrence or progression of coronary heart disease is provided. The method involves administration of a selected active agent to a patient following coronary intervention, e.g., coronary artery bypass surgery, endarterectomy, heart transplantation, heart balloon angioplasty, atherectomy, laser ablation or endovascular stenting. The active agent comprises cis-resveratrol, trans-resveratrol, a mixture thereof, or a pharmacologically acceptable salt, ester, amide, prodrug or analog thereof. Administration may be oral, parenteral, or the like. Pharmaceutical compositions for use in conjunction with the therapeutic method are also provided.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: February 8, 2000
    Assignee: Pharmascience Inc.
    Inventor: David William Goodman
  • Patent number: 6004951
    Abstract: Disclosed are pharmaceutical compositions that comprise gallium complexes of 3-hydroxy-4-pyrones. These compositions provide enhanced gallium bioavailability particularly when orally administered as compared to the gallium bioavailability achieved by use of pharmaceutical compositions containing gallium salts. Compositions included in this invention are useful in providing gallium to humans and other mammals for a wide variety of medical and veterinary applications, including the treatment, prevention, or diagnosis of hypercalcemia, certain cancers, certain disorders of calcium homeostasis, and certain bone diseases including osteoporosis, osteopenia, and Paget's disease.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: December 21, 1999
    Inventor: Lawrence Richard Bernstein
  • Patent number: 5998397
    Abstract: Disclosed are pharmaceutical compositions that comprise gallium complexes of 3-hydroxy-4-pyrones. These compositions provide enhanced gallium bioavailability particularly when orally administered as compared to the gallium bioavailability achieved by use of pharmaceutical compositions containing gallium salts. Compositions included in this invention are useful in providing gallium to humans and other mammals for a wide variety of medical and veterinary applications, including the treatment, prevention, or diagnosis of hypercalcemia, certain cancers, certain disorders of calcium homeostasis, and certain bone diseases including osteoporosis, osteopenia, and Paget's disease.
    Type: Grant
    Filed: January 29, 1998
    Date of Patent: December 7, 1999
    Inventor: Lawrence Richard Bernstein
  • Patent number: 5990024
    Abstract: Novel methods for the preparation of polymers useful as precursors to ceramic materials by catalytic activation of Si--H bonds are disclosed. The methods comprise reacting, in the presence of a catalyst effective to activate Si--H bonds, Si--N bonds, or both, and/or a reactive solvent, a polymer in the form of a polysilane, polysilazane, polysiloxane or polycarbosilane with a reactant having the structural formula R--X--H, wherein X is NR' or O, R is H, organic, silyl, siloxyl, silazanyl or carbosilyl and may contain at least one additional X--H group, and R' is H, amino, silyl or silazanyl, to produce a modified polymer containing at least one Si--X bond. Polymers produced by these methods are also disclosed.
    Type: Grant
    Filed: June 16, 1997
    Date of Patent: November 23, 1999
    Assignee: SRI International
    Inventors: Yigal Blum, Gregory A. McDermott
  • Patent number: 5986024
    Abstract: A process is provided for preparing polymer compositions which are multimodal in nature. The process involves contacting, under polymerization conditions, a selected addition polymerizable monomer with a metallocene catalyst having two or more distinct and chemically different active sites, and a catalyst activator.
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: November 16, 1999
    Assignee: SRI International
    Inventor: Robert B. Wilson, Jr.
  • Patent number: 5985524
    Abstract: The invention relates to a process for forming bilayer resist images with a chemically-amplified, radiation-sensitive bilayer resist. The bilayer resist is disposed on a substrate and comprises (i) a top imaging layer comprising a radiation-sensitive acid generator and a vinyl polymer having an acid-cleavable silylethoxy group and (ii) an organic underlayer. The bilayer resist is used in the manufacture of integrated circuits.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: November 16, 1999
    Assignee: International Business Machines Incorporated
    Inventors: Robert David Allen, Donald Clifford Hofer, Ratnam Sooriyakumaran, Gregory Michael Wallraff
  • Patent number: 5976085
    Abstract: A method is provided for calibrating sensors used to analyze characteristics of physiologic fluids such as blood. The method involves the use of a sensor assembly having an analyte-responsive sensor in communication with a passageway which is in divertable fluid communication with a physiologic line and a conduit by which a reference sample may be introduced into the passageway. The method involves exposing the sensor to the reference sample, thereby producing a sensor response. The method also allows performing quality control on the sensors. Also provided is an apparatus with which the claimed method may be practiced.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: November 2, 1999
    Assignee: Optical Sensors Incorporated
    Inventors: Victor E. Kimball, Laurie E. Lynch, Irvin T. Pierskalla, Christopher H. Porter
  • Patent number: 5976666
    Abstract: Novel devices for providing shielding from and absorption of broadband electromagnetic radiation, and methods of manufacturing and using these devices, are disclosed. The device is comprised of a perforated electrical absorbing layer, containing conductive polymers, laminated to a metal plate. Additional layers may be incorporated into the device including one or more additional layers of electrical absorbing layers, magnetic absorbing layers and impedance matching layers.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: November 2, 1999
    Assignee: SRI International
    Inventors: Subhash C. Narang, Asutosh Nigam, Sei-ichi Yokoi, Robert C. Schmitt, Kenneth J. Harker, Mark A. McHenry