Patents Represented by Attorney Dianne Reed

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  • Method of purifying toxin conjugates using hydrophobic interaction chromatography
    Patent number: 4771128
    Abstract: A method of isolating and purifying toxin conjugates using hydrophobic interaction chromatography. Crude conjugate mixtures are sized to remove unconjugated toxin, and loaded onto a column filled with a suitable hydrophobic gel. Elution is effected with salt solutions of decreasing ionic strength, which salt solutions optionally include increasing amounts of an organic solvent. Toxin conjugate substantially free of unconjugated Ig and unconjugated toxin is provided.
    Type: Grant
    Filed: October 10, 1986
    Date of Patent: September 13, 1988
    Assignee: Cetus Corporation
    Inventors: Robert Ferris, Walter J. Laird