Abstract: The present invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention provides a process for the manufacture of a compound of the formula III, wherein R, R1, R2, R3 and PG are as defined in the specification, or a salt thereof. The manufacture comprises (preferably consists of) reacting a compound of the formula I, with a reagent able to transform hydroxy into X where X is for example a leaving group.

Abstract: A semiconductor device comprises a first layer (1) of a wide band gap semiconductor material doped according to a first conductivity type and a second layer (3) on top thereof designed to form a junction blocking current in the reverse biased state of the device at the interface to said first layer. The device comprises extension means for extending a termination of the junction laterally with respect to the lateral border (6) of the second layer. This extension means comprises a plurality of rings (16-21) in juxtaposition laterally surrounding said junction (15) and being arranged as seen in the lateral direction away from said junction alternatively a ring (16-18) of a semiconductor material of a second conductivity type opposite to that of said first layer and a ring (19-21) of a semi-insulating material.

Abstract: A high throughput neurophysiological assay for identifying anti-psychotic compounds is disclosed. In particular, a high throughput neurophysiological assay using information obtained from injecting a neural activity blocker, such as tetrodotoxin (TTX), into one hippocampus persistently coactivated pyramidal cells in the uninjected hippocampus that initially discharged independently. In accord with the definition of cognitive disorganization, pyramidal cell firing rates only changed for 15 min and did not accompany the coactivation. The disclosed assay uses the TTX-induced coactivity of hippocampal pyramidal cell discharge to identify compounds that may prevent or attenuate the changes in the hippocampal pyramidal cell discharge observed when a neural activity blocker is administered. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that have anti-psychotic properties.

Abstract: The present invention provides a porous body high in safety against environment and living bodies and having a strength high enough to withstand practical use, said porous body comprising, as a skeleton constituent thereof, sericin with an average molecular weight of 30000 to 400000, and having a recovery rate of 10 to 100% after 50% compression.

Abstract: A crude phosphate ester product can be purified by first washing it with chelating agent composition (such as a dilute acidic solution) and then, preferably, water, drying the resulting product, and then treating the resulting product with an acid scavenger, as exemplified by an epoxy-containing compound, such as 3,4-epoxy cyclohexyl methyl-3,4-epoxy cyclohexyl carboxylate.

Abstract: A bed mattress is provided for employing a plurality of cushion elements to be arranged in different portions of the mattress divided corresponding to the user's body parts and have appropriate elasticity for the corresponding part of the user's body, which comprises a mattress frame with an enclosing wall of elastic material for providing a mounting space therein; a plurality of cushion elements disposed in the mounting space and forming a mattress body together with the mattress frame; a side pad covering the periphery of the mattress body; and upper and lower cover pads with outer edges fastened respectively to the top and bottom edges of the side pad to enclose the upper and lower surfaces of the mattress body.

Abstract: A composition for surface conditioning includes bivalent or trivalent metal phosphate particles having a pH of 3 to 12, with D50 of the particles being 3 ?m or less and including an amine compound having a MW of 1000 or less, plus at least one metal alkoxide in a content of from 0.01 to 1000 parts by weight per 100 parts by weight of the solid content of the metal phosphate particles.

Abstract: The present invention provides peptides corresponding to all or a portion of amino acid residues 12-26 of human p53 protein. When fused to a membrane-penetrating leader sequence, the peptides are either lethal to malignant or transformed cells or else cause reversion to the untransformed morphological phenotype. The subject peptides are thus useful in treating neoplastic disease in an animal, preferably a human. Also provided are pharmaceutical compositions comprising the subject peptides admixed with a pharmaceutical acceptable carrier. Methods of treating neoplastic disease in a patient by administering a subject peptide are also provided.

Abstract: A bar type ionizer has a discharging electrode, a ground electrode, a high voltage unit, and a controller unit and uses the technique of eliminating static electricity by corona discharging. The ionizer also has a FND unit mounted on the bar which lets the user see the bar information including address of the bar, frequency, duty rate, alarm, run/stop state easily, plus buttons that let the user control the bar information easily, an air supply device installed around the needles in the air injecting socket which sends air, and a second air supply device installed around the needles having round sections and sending air to the end of the needles to eliminate the dust attached on the end of the needles. The ionizer has a streamlined section so that inside air flows smoothly. The second air supply device is elliptic with the minor axis smaller than the radius of the needle. The needle is positioned at the center of this elliptic groove and fixed by it.

Abstract: The present invention presents an exposure device, which includes an optical source for emitting a UV ray, a lighting system for shaping the UV ray into a collimated light beam, an aperture member for producing rectangular first and second light beams based on the light beam from lighting system by using the first and second rectangular windows, first and second spatial light modulators for spatially modulating the first and second light beams, respectively, and first and second projection lighting systems for guiding the modulated first and second light beams to the object.

Abstract: A semiconductor device of unipolar type has Schottky-contacts (6) laterally separated by regions in the form of additional layers (7, 7?) of semiconductor material on top of a drift layer (3). Said additional layers being doped according to a conductivity type being opposite to the one of the drift layer. At least one (7?) of the additional layers has a substantially larger lateral extension and thereby larger area of the interface to the drift layer than adjacent such layers (7) for facilitating the building-up of a sufficient voltage between that layer and the drift layer for injecting minority charge carriers into the drift layer upon surge for surge protection.

Abstract: The invention relates to a security system especially for security documents, wherein a security element is provided in a carrier plane, that under incident light holographically reconstructs a pattern outside the carrier plane, in which concealed information is stored and having a flat transparent verification element which on flat contact with the security element makes the information stored therein visible. The invention further relates to a security element and a verification element for use in the security system and a security document fitted with the security system. The invention additionally relates to an apparatus and a method for reading out the concealed information which is stored holographically in the pattern reconstructed on the security element under incident light.

Abstract: A surface-conditioning composition can form a denser phosphate coating film having more satisfactory coating weight on the surface of a metal material compared to a conventional one and, therefore, can reduce the electrolytic corrosion of a metal material during a chemical conversion treatment, form a chemical conversion coating film having a satisfactory coating weight even when applied to a hardly convertible metal material (e.g., an aluminum metal material, a high tensile strength steel plate), improve the productivity rate of the chemical conversion treatment, resulting in the reduction of the time required for the chemical conversion treatment, and enables a metal phosphate particle to be dispersed in a surface-conditioning solution highly stably. This composition includes a particle of a phosphate of a bivalent or trivalent metal and has a pH value ranging from 3 to 12. The particle has a D50 value of 3 ?m or less.

Abstract: An arrangement for clamping a thin rod of glass or quartz having a diameter below 1 mm in two mutually-spaced clamping locations for holding the rod extended between the two clamping locations. The arrangement also comprises first clamping device arranged to clamp the rod in a first clamping location. The first clamping device has a first clamping member (22) with a clamp face (23) of substantially V-groove type for receiving the rod in the groove (24). The first clamping member is movably arranged with respect to a framework (45) of the apparatus for clamping a rod.

Abstract: A signal processor and a tracking method of a signal search range are provided which can read out precisely a specific spectrum having frequency varied. A signal processor includes an FFT computation portion to compute spectrum data by fast-Fourier-transforming an input signal, a spectrum selection portion to select a specific spectrum, a spectrum search portion to search sequentially the specific spectrum selected by the spectrum selection portion from the spectrum data computed by the FFT computation portion, and a search range computation portion to compute the search range of the spectrum searched by the spectrum search portion based on the frequency of the specific spectrum, in which the search range computation portion computes the search range based on the varied frequency of the specific spectrum and makes it track the varied specific spectrum, when the frequency of the specific spectrum varies.

Abstract: A flexible ionizer uses soft X-ray and has a head unit generating soft X-ray whose wavelength is 1.2˜1.5 ?, a soft X-ray protect unit shielding the leak of the soft X-ray from the head unit, and a power control unit supplying a control signal and control voltage to the head unit. The head unit is positioned outside of the soft X-ray protect unit with the flexible ionizer further having a flexible tube protecting a high voltage cable that connects the head unit and power control unit from external impact or vibration and letting the user bend the head of the head unit at an arbitrary angle toward a charged body if necessary, a connecting device letting the ions generated at the window positioned inside of the body of the ionizer emit toward the charged body by connecting one end of the flexible tube and the head unit, and a connecting device connecting the other end of the flexible tube and the body of the ionizer.

Abstract: A device for detecting synchronous errors of high-lift surfaces such as landing flaps or slats on aircraft, having an optical conductor which is laid over at least two adjacent high-lift surfaces, a light source and an optical receiver which are allocated to different ends of the optical conductor, as well as an evaluation unit for determining a synchronous error of the high-lift surfaces on the basis of the light signal received from the optical receiver.

Abstract: The invention relates to a quick coupling comprising a base plate and a support plate, with the mounting frame being guided movably at the base plate and having means for connection to the support plate. In accordance with the invention, the support plate is moved toward the base plate by means of the mounting frame to close the coupling.

Abstract: This invention relates to a lattice piece for a large mobile crane, comprising four corner posts and null bars and diagonal bars connecting the same. In accordance with the invention, the lattice piece each is divided in two such that one part of the null and diagonal bars each is foldably hinged at two corner posts connected with each other. Furthermore, the invention relates to a method for erecting such lattice piece.

Abstract: The present invention presents an exposure device, which includes an optical source for emitting a UV ray, a first lighting system for shaping the UV ray into a collimated light beam, an aperture member for producing rectangular first and second light beams based on the light beam from first lighting system by using the first and second rectangular windows, first and second spatial light modulators for spatially modulating the first and second light beams, respectively, and first and second projection lighting systems for guiding the modulated first and second light beams to the object.