Abstract: This application describes an information and resource management system for collecting data from diverse sources and organizing multiple types of data and information to facilitate dynamic multi-dimensional displays that will enhance cognition and situational awareness for diverse user communities. This system may facilitate collaborative cross-agency research and response to public health and safety issues. The system will generate more rapid awareness of potentially critical situations and promote greater awareness of the cost and benefits of alternative courses of action across diverse agencies and organizations serving common populations and communities. The invention includes customized geographically enabled data collection tools and techniques, dedicated databases and parsing schemes that feed into customized data visualization and simulation engines that drive the display of context sensitive interactive environments on a wide variety of computing platforms.

Abstract: Devices, systems, and methods for the precise dispensation of small volumes of liquids are presented. A fluid microdispenser comprises a liquid-filled tube, an actuator coupled to the tube, and a tip at one end of the tube. When the actuator applies an actuation pressure, a precise volume of liquid is ejected from the orifice of the tip. The orifice is manufactured to control the volume of liquid ejected by each actuation and, therefore, may have a diameter smaller than that of the liquid-filled tube. The invention comprises systems, methods, and devices so that the inner diameter of the liquid-filled tube is decreased (tapered) to that of the orifice so as to maximize transmission to the orifice of the pressure generated by the actuation stimulus. This enables the volume of liquid ejected by each stimulus to be reproducibly controlled by the amplitude of the actuation stimulus.

Abstract: This invention provides compositions and methods for cryoprotection of recombinant live cancer cells. Specifically, an improved cryoprotective medium is provided which includes a hydroxyethyl starch and/or derivative thereof alone or in combination with either DMSO or glycerol.

Abstract: A tissue approximation device and processes for using the device are provided. The device is an implantable, biodegradable construct (except for hernia repairs) that has attachment points emanating from a supportive backing. The device improves the mechanical phase of wound healing and evenly distributes tension over the contact area between the device and tissue. Processes for using the device include wound closure, vascular anastomoses, soft tissue attachment and soft tissue to bone attachment.

Abstract: Methods are provided for detecting a cell proliferative disorder associated with TSLC1 by contacting a proliferating cell of a subject suspected of having the disorder with a reagent that detects TSLC1 and detecting the level of TSLC1 in the proliferating cell. TSLC1 is a single gene whose expression is reduced or absent in A549 and some other NSCLC, hepatocellular carcinoma and pancreatic cancer cell lines. It has further been discovered that TSLC1 expression or suppression is perfectly correlated with promoter methylation state. Restoration of TSLC1 expression to normal or higher levels is sufficient by itself to suppress tumor formation. The invention further provides methods of treating such disorders by contacting cells of a patient suffering from the disorder with a therapeutically effective amount of a reagent that modulates TSLC1 level in the proliferating cells.

Abstract: The present invention provides a method for detecting a cellular proliferative disorder in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant methylation of regions of the gene or regulatory region, wherein aberrant methylation is identified as being different when compared to the same regions of the gene or associated regulatory region in a subject not having said cellular proliferative, thereby detecting a cellular proliferative disorder in the subject.

Abstract: Common allergenic foods are made hypoallergenic by treatment with super critical fluid or critical liquid gas such as super critical carbon dioxide or liquid nitrogen. The treatment of foods with liquid nitrogen or super critical carbon dioxide also enhances the functionality of fat, so that the total fat in the food can be reduced while retaining the good taste of the food. Compositions and methods for the oral delivery of a medicament or vitamin are also provided.

Abstract: A memory comprises a plurality of digital multilevel memory cells. A window of valid data voltages for accessing the said plurality of digital multilevel memory cells is detected. The window may be detected by incrementing a first programming voltage to program data in the plurality of memory cells and verifying whether the data in at least one of said plurality of memory cells is properly programmed. The incrementing and verifying may be repeated until data is verified to be properly programmed in one of said plurality of memory cells. The data in each memory cell of said plurality of memory cells is verified. The verification may be by incrementing a second programming voltage, and verifying whether data in each memory cell is properly programmed within a margin. The incrementing and verifying is repeated for each memory cell outside of the margin.

Abstract: In a computer system constituted by a portable computer and a deskstation used to expand the function of the portable computer, the portable computer has a communication connector used for communication with the deskstation, in addition to a connector for connecting a system bus in the portable computer to the deskstation. Similarly, the deskstation also has a communication connector. When the portable computer is set at a predetermined position of the deskstation, these connectors are connected to each other before the system bus is connected to an expansion device of the deskstation. By using the communication connectors to perform communication between the portable computer and the deskstation, disconnection between the system bus and an expansion connector or forced suspend processing of the portable computer is executed before the portable computer in a power ON state is mounted in the deskstation. In addition, a lock mechanism is provided to lock the portable computer with the deskstation.

Abstract: The invention is the discovery of an actinomycete genus, given the name Salinospora gen. nov., that displays an obligate requirement of seawater (Na+) for growth and unique 16S rRNA signature nucleotides. The invention is also the use of the genus for the production and discovery of active biomolecules such as pharmaceutical agents, agrichemicals, immunomodifiers, enzymes and enzyme inhibitors.

Abstract: A dispenser is provided for delivering a controlled quantity of a granular material. The dispenser includes a container assembly, a diffuser and a metering cup. The container includes a reservoir which supports a disposable cartridge of granular material. The cartridge is supported in the reservoir so as to define a passageway therebetween. A nozzle is defined for the outflow of material from the cartridge. The diffuser is disposed on one end of the container and includes a plurality of apertures. The metering cup is disposed on the opposite end of the container and has an open end adapted to receive granular material. Adjustment of the axial spacing between the nozzle and metering cup varies the quantity of granular material collected in the cup. The granular material is dispensed by inverting the container to a second orientation, such that material flows out of the metering cup, through the passageway and out of the diffuser.

Abstract: According to one embodiment, a metadata management system (MDS) may include partitioned migratable metadata. Metadata may be stored in multiple metadata partitions (102-0 to 102-11). Each metadata partition may be assigned to a particular system resource (104-0 to 104-5). According to predetermined policies, such as metadata aging, metadata stored in one metadata partition may be migrated to a different metadata partition. A forwarding object can be placed in the old metadata partition to indicate the new location of the migrated metadata. Metadata partitions (102-0 to 102-11) may be reassigned to different resources, split and/or merged allowing a high degree of scalability, as well as flexibility in meeting storage system needs.

Abstract: A gem microscope according to the invention includes a focus column, a stage, and a quick disconnect mechanism that facilitates removable coupling of the focus column to the stage. The focus column and the stage have compatible features that establish the proper mounting plane and lateral alignment of the focus column relative to the stage. In the example embodiment, the quick disconnect mechanism includes a threaded element on the focus column and a compatibly threaded thumbwheel that rotates within the stage to connect/disconnect the focus column to/from the stage.

Abstract: A optical fiber sensor for measuring temperature and/or pressure employs temporally created long period gratings. The gratings may be produced by a periodic change in the refractive index of the fiber along the fiber longitudinal axis caused by periodically spaced compressive and/or expansive forces or by spaced-apart unbalanced forces that cause periodic fiber micro-bending. Pressure and temperature are determined by measuring changes in both the wavelength at which light is coupled from a mode guided by a core to a different mode and an amount of such coupling. The gratings are created intrinsically and extrinsically. Single and multiple core fibers are used.

Abstract: A cable guide for a cable support system that includes at least one support tray. The cable guide has a base with two base portions disposed in side by side relation. The base portions are adapted to cooperatively engage wires of the support tray(s). A support shaft extends from at least one of the base portions, and a roller is rotatably mounted on the support shaft and engage cables so that they may be turned along a path defined by the cable trays.

Abstract: Grain-oriented magnetic steel sheet made by the method-including hot rolling and final finish annealing, wherein (1) the O content in the steel slab is limited to up to about 30 ppm; (2) for the entire steel sheet having final thickness including an oxide film before final finish annealing, from among impurities, the Al content is limited to up to about 100 wtppm, and the respective contents of B, V, Nb, Se, S, P, and N, to up to about 50 wtppm each; and (3) during final finish annealing, the N content in the steel is, at least in the temperature region of from about 850 to 950° C., limited within the range of from about 6 to 80 wtppm.