Abstract: Small, round, bio-compatible microspheres capable of covalently bonding proteins and having a uniform diameter below about 3500 A are prepared by substantially instantaneously initiating polymerization of an aqueous emulsion containing no more than 35% total monomer including an acrylic monomer substituted with a covalently bondable group such as hydroxyl, amino or carboxyl and a minor amount of a cross-linking agent.
Type:
Grant
Filed:
May 26, 1978
Date of Patent:
September 23, 1980
Assignee:
California Institute of Technology
Inventors:
Alan Rembaum, Shiao-Ping S. Yen, William J. Dreyer