Abstract: Disclosed is an improved writing instrument having a slidably and pivotably disposed cap for covering the writing tip. The improved cap retaining feature improves the manageability of the instrument such that the cap can be removed and lodged into its open position by a continuous motion of the hand which is holding the instrument.

Abstract: Intravenous infusion sets suitable for the parenteral administration of nitroglycerin solutions and methods of using such sets are provided. The intravenous infusion sets and methods herein utilize flexible drip tubes having their inner surfaces constructed of polyolefin plastic material. Polyolefin or polyolefin-lined drip tubes can be advantageously used to infuse nitroglycerin solutions with minimized loss of nitroglycerin solution potency.

Abstract: The present invention relates to new compounds of the general formula: ##STR1## where X is iodine or hydrogen; A is a linking portion; and R is an iodinatable aryl or heteroaryl group having electron donating substituents. These compounds are useful precursors to the iodinated thyroid hormones for radioimmunoassay determination of thyroid hormones in biological fluids.

Abstract: A blood oxygenating device having an oxygenating chamber and a heat exchanger chamber. The oxygenating chamber consists of a bubbler chamber and a mixing chamber. Oxygen is introduced into the bubbler chamber through a porous diffusion means situated near the inlet of the bubbler chamber. Bubbles pass from the bubbler chamber into a mixing chamber which is provided with a plurality of secondary flow-producing deflectors to promote secondary flow of blood bubbles passing therethrough. The secondary flow results in a highly efficient oxygen-carbon dioxide transfer. The blood bubbles are then passed through a heat exchange chamber and a defoaming means prior to exiting the oxygenating device.

Abstract: Novel compounds of the general formula ##STR1## wherein R.sub.1 is lower alkyl, lower cycloalkyl, lower alkenyl, lower alkynyl, lower alkyl carboxymethyl, aryl carboxymethyl, aryl, or aralkyl; A is a direct bond, lower alkylene, or lower alkenylene; x is 1 or 2, provided that when x is greater than 1, different occurrences of the ##STR2## group may be the same or different; Ar is heterocyclic, unsubstituted aromatic or aromatic substituted with lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, halogen, acetamido, amino, nitro, lower alkylamino, hydroxy, lower hydroxyalkyl or cyano; W is alkylene containing from 1 to about 10 carbon atoms; and B is --NR.sub.2 COR.sub.3, --NR.sub.2 CONR.sub.3 R.sub.4, --NR.sub.2 SO.sub.2 R.sub.3, --NR.sub.2 SO.sub.2 NR.sub.3 R.sub.4, or --NR.sub.2 COOR.sub.5, wherein R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be the same or different and may be hydrogen, alkyl, alkoxyalkyl, alkoxyaryl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl, except that R.sub.3 and R.

Abstract: Disclosed is a method of using soft biological tissue to interface between a surgically implanted prosthesis, tendon or ligament, and the surface of resected bone to promote the even remodeling of said resected bone.

Abstract: A surgical instrument container has a top and bottom whose opposing surfaces are bordered by sidewalls and articulately connected to form an enclosed box. A planar substrate having upper and lower surfaces adapted to receive surgical instruments is pivotally mounted between the top and bottom. When the box is open, the substrate can be pivoted between the top and bottom to provide easy access to both upper and lower substrate surfaces. The substrate is positioned within the sidewalls of the top and bottom surfaces to effect enclosure of the substrate when the box is closed and thereby prevent retained surgical instruments from protruding through or falling out of the box. The substrate may be a porous foam or magnetic material or combination of each. The box may be mechanically or magnetically latched. The box may be composed of transparent material to permit visual inspection of the retained instruments when the box is closed.

Abstract: A disposable collector for surgical implements which utilizes a pair of sponge plastic pads movable between a coplanar position to receive surgical implements, such as semicircular-shaped surgical needles and a folded position with their peripheral or frame portions in mutual contact to form an enclosure having depressed areas defining rows and columns of implement receiving elements, bordered by areas of depressions.In one embodiment the implement receiving elements are completely surrounded by depressed portions; in another embodiment a pair of crescent-shaped depressed portions extend in opposite directions from the implement receiving elements.

Abstract: Novel compounds of the general formula ##STR1## wherein Ar represents a substituted or unsubstituted aromatic or heterocyclic group; W represents alkylene of from 1 to about 10 carbon atoms; and B represents --NR.sub.2 COR.sub.1, --NR.sub.2 CONR.sub.1 R.sub.3, --NR.sub.2 SO.sub.2 R.sub.1, --NR.sub.2 SO.sub.2 NR.sub.1 R.sub.3, or --NR.sub.2 COOR.sub.1 wherein R.sub.1, R.sub.2 and R.sub.3 may be the same or different and may be hydrogen, alkyl, alkoxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl, except that R.sub.1 is not hydrogen when B is --NR.sub.2 SO.sub.2 R.sub.1 or --NR.sub.2 COOR.sub.1, or R.sub.1 and R.sub.3 may together with N form a 5 to 7 momoered heterocyclic group; and the pharmaceutically acceptable salts thereof. These compounds exhibit .beta.-adrenergic blocking activity and are also useful in the treatment of glaucoma.

Abstract: A container closure includes a cover portion and a rim portion at the edge of, and upstanding from the cover portion; the rim includes a flat, solid, annular ring member surrounding a raised, solid, round-shouldered, circular center area; the rim portion surrounds the cover portion and includes an upstanding, annular wall with an outwardly-projecting annular flange for engaging the inner surface of a container at its opening and, at the top edge of the annular wall, a planar flange parallel to the cover portion for seating on the rim of a container opening.

Abstract: The present invention relates to new compounds of the formula ##STR1## where X is ##STR2## alkylene, or --S-- where R.sub.1 is hydrogen, alkyl, or aryl; W is hydrogen, hydroxy, amino, alkyloxy, aryloxy, O-alkyl, or O-aralkyl; (Y).sub.A is --CH.sub.2 NR.sub.2 R.sub.3 where R.sub.2 and R.sub.3 may be hydrogen, substituted alkyls, aryls, or together with N form a 5 to 7 membered heterocyclic group; and Ar is a substituted or unsubstituted aryl. These compounds are useful in the treatment of various cardiac arrhythmias.

Abstract: Described herein are compounds of the formula ##STR1## wherein R.sub.1 is alkyl of from 1 to about 5 carbon atoms, alkenyl of from 2 to about 5 carbon atoms, alkynyl of from 3 to about 5 carbon atoms, cycloalkyl of from 3 to about 7 carbon atoms, alkylcarboxymethyl wherein the alkyl portion is from 1 to about 5 carbon atoms, arylcarboxymethyl wherein the aryl portion is from 6 to about 10 carbon atoms, aryl of from 6 to about 10 carbon atoms, or aralkyl wherein the alkyl portion is from 1 to about 5 carbon atoms and the aryl portion is from about 6 to about 10 carbon atoms; R.sub.2 and R.sub.

Abstract: A system for applying relatively large adhesive backed bandages to a patient for a wound dressing, burn dressing, surgical incise drape, etc. The system includes an applicator handle that is substantially less flexible than the bandage, which is joinable to the bandage during application, but which is removed from the bandage so as not to interfere with the flexible functioning of such bandage on a patient's anatomy.

Abstract: A heat-radiating cover for food dishes includes an outer shell joined at its periphery to the periphery of an inner shell having a shape complentary to and fitting within the outer shell and, mounted atop the outer shell and in the space between the outer and inner shells, a heat sink for absorbing radiating heat through the inner shell to the space beneath it, with the balance of the space between the inner and outer shells filled with insulation.

Abstract: Novel compounds are disclosed having the formula ##STR1## wherein R is lower alkyl, lower cycloalkyl, lower haloalkyl, lower alkylcarboxymethyl, arylcarboxymethyl, lower alkenyl, lower alkynyl, aryl having from 6 to about 10 carbon atoms, or aralkyl; R.sub.1 is lower alkyl, lower hydroxyalkyl, lower alkenyl, lower alkynyl, aralkyl, or --WB; where W is alkylene containing from 1 to about 10 carbon atoms; and B is --NR.sub.2 COR.sub.3, --NR.sub.2 CONR.sub.3 R.sub.4, --NR.sub.2 SO.sub.2 R.sub.3, --NR.sub.2 SO.sub.2 NR.sub.3 R.sub.4, or --NR.sub.2 COOR.sub.5, where R.sub.2, R.sub.3, R.sub.4, and R.sub.5 may be the same or different and may be hydrogen, alkyl, alkoxyalkyl, alkoxyaryl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl, except that R.sub.3 and R.sub.5 are not hydrogen when B is --NR.sub.2 SO.sub.2 R.sub.3 or --NR.sub.2 COOR.sub.5, or R.sub.3 and R.sub.

Abstract: A hollow dish with a discrete, meltable core such as a wax core includes top and bottom members welded to one another at their periphery, and a meltable, preferably wax core confined within an oxygen-free, water-free cavity between the top and bottom members. A method for making a hollow dish with such a core includes liquifying a meltable substance such as wax in an oxygen-free, water-free, inert atmosphere; cooling and solidifying the meltable substance to form a meltable core; placing the meltable wax core in the cavity inside a hollow dish; removing all oxygen and water from the core-containing cavity inside the hollow dish; and sealing the hollow dish to preclude escape of the wax core from the cavity and to preclude oxygen and water from entering the cavity.

Abstract: A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes the incorporation of biocompatible polymers into the tissue in an amount effective in reducing calcification of the implanted tissue.

Abstract: A disposable or reusable "crawl resistant" flexible mattress formed of panels sealed together to define alternately inflatable passages between the panels for sequentially supporting structure for a long term bed patient to reduce decubitus ulcers, bed sores, etc. The mattress has vent holes in its top for ventilating the patient with inflation gas and a crawl resistant layer bonded to a bottom of the mattress to prevent the mattress from "crawling" relative to the bed and patient during use. In one form of the mattress, crawling is reduced by a separation between the inflation passages so individual sections of the mattress can more readily conform to a patient's body contour.

Abstract: The present invention relates to new compounds of the formula ##STR1## alkylene, or --S-- where R.sub.1 is hydrogen, alkyl, or aryl; W is hydrogen, hydroxy, amino, alkyloxy, aryloxy, O-alkyl, or O-aralkyl; (Y).sub.A is --CH.sub.2 NR.sub.2 R.sub.3 where R.sub.2 and R.sub.3 may be hydrogen, substituted alkyls, aryls, or together with N form a 5 to 7 membered heterocyclic group; and Ar is a substituted or unsubstituted heteroaryl. These compounds are useful in the treatment of various cardiac arrhythmias.