Abstract: Silicon (Si) is cast into thin shapes within a flat-bottomed graphite crucible by providing a melt of molten Si along with a relatively small amount of a molten salt, preferably NaF. The Si in the resulting melt forms a spherical pool which sinks into and is wetted by the molten salt. Under these conditions the Si will not react with any graphite to form SiC. The melt in the crucible is pressed to the desired thinness with a graphite tool at which point the tool is held until the mass in the crucible has been cooled to temperatures below the Si melting point, at which point the Si shape can be removed.

Abstract: 5-Iminodoxorubicin and its pharmaceutically acceptable acid addition salts having good antitumor activity.

Abstract: Described are 3'-deamino-3'-(4-morpholinyl) derivatives of daunorubicin and doxorubicin having the formula ##STR1## wherein R is COCH.sub.3 or --CHOHCH.sub.3 in the case of daunorubicin derivatives, or is --COCH.sub.2 OH or --CHOHCH.sub.2 OH in the case of doxorubicin derivatives together with their pharmaceutically acceptable acid addition salts. The compounds have utility as antitumor agents.

Abstract: Process for repelling ticks and other biting insects comprising topically administering to humans or to domesticated animals a composition comprising at least one active compound selected from the group made up of alkylated pyrrolidones and alkylated pyrrolidenones.

Abstract: Adriamycin octanoylhydrazone, and its pharmaceutically acceptable salts, having good antitumor activity coupled with low toxicity.

Abstract: Novel N-sec-alkyl derivatives of norcodeine and normorphine wherein the sec-alkyl group contains either four or five carbon atoms. Specifically included are those derivatives of norcodeine and normorphine wherein the sec-alkyl group is 2-butyl, 3-pentyl, .alpha.-methylallyl and .alpha.-methylcyclopropylmethyl. The normorphine derivatives having strong agonist potency combined with strong antagonist qualities and indicated low addiction potential. The norcodeine analogs are useful as intermediates in preparing the corresponding normorphine compounds.

Abstract: N-Benzyl and N,N-dibenzyl derivatives of the anthracycline compounds adriamycin and daunomycin, said derivatives having anticancer properties and being active against leukemia P-388 in mice, for example. The N,N-dibenzyl derivatives have the unique quality of exhibiting a loss of DNA-binding properties.

Abstract: Increased yields of the cellulolytic enzymes from Thielavia terrestris are effected by novel separatory methods for the produced enzymes as well as the enhancement of the production of one of the enzymes, namely .beta.-glucosidase, by the addition of glycerol to the media. Further, since the .beta.-glucosidase is responsible for glucose production from cellulose, a method is provided wherein the separated .beta.-glucosidase can be employed as, for example, on a fixed support in a position to receive concentrated streams of partially converted cellulosic materials, thereby leading to enhanced glucose production.

Abstract: Glyoxylic acid hydrocarbylsulfonylhydrazones and therapeutic compositions containing the same. Said compounds are useful in treating cancer, they being active against leukemia P-388, for example.

Abstract: Described are N,N-pentamethylene derivatives of daunomycin and adriamycin having the formula: ##STR1## wherein R.sup.1 is --COCH.sub.3 or --CHOHCH.sub.3 in the case of daunomycin derivatives, or --COCH.sub.2 OH or --CHOHCH.sub.2 OH in the case of adriamycin derivatives. The compounds have utility as antitumor agents.

Abstract: N-Benzyl and N,N-dibenzyl derivatives of the anthracycline compounds adriamycin and daunomycin, said derivatives having anticancer properties and being active against leukemia P-388 in mice, for example. The N,N-dibenzyl derivatives have the unique quality of exhibiting a loss of DNA-binding properties.

Abstract: Rubidazone analogs wherein the phenyl group is substituted by one of 4-phenyl, 4-chloro, 3,4-dichloro or 3-nitro, said compounds having high antitumor activity coupled with desirably low cardiotoxicity.

Abstract: Bis-hydrazones of daunomycin and adriamycin having useful antitumor characteristics and the structure ##STR1## WHEREIN N IS AN INTEGER HAVING A VALUE OF FROM 0 THROUGH 8 AND THE RADICALS INDICATED BY R and R' each represent hydrogen except that in those instances in which n has a value of 2, the R groups, if not hydrogen, may be methyl radicals (with R' remaining as hydrogen), and the R' groups, if not hydrogen, may be hydroxy radicals (with R remaining as hydrogen).

Abstract: 5-Iminodaunomycin having good antitumor activity coupled with low cardiotoxicity.

Abstract: Septacidin analogs, useful as antitumor agents, having the structure ##STR1## where R is a branched or straight chain alkanoyl group of from 12 to 16 carbon atoms. A preferred compound is 6-[4,6-dideoxy-4-(isopalmitoylglycyl)-amino-.beta.-L-glucopyranosylamino]- 9H-purine.

Abstract: A thermostable cellulase preparation exhibiting C.sub.1 and C.sub.x cellulytic activities at a temperature from about 60.degree. to about 70.degree. C at a moderately acid pH from about 5.0 to about 5.6 is obtained by culturing the thermophilic fungus Thielavia terrestris (NRRL 8126) in a suitable cellulose-containing medium and recovering the cellulases thus produced.

Abstract: The compounds 3-(N-diethylcarbamyl)amino-1-methyl pyrrolidine, 3-(N-carbethoxy-N-methyl)amino-1-methyl pyrrolidine, 1-diethylcarbamyl-3-(N-methyl)amino pyrrolidine and 1-diethylcarbamyl-3-dimethylamino pyrrolidine, said compounds having utility as antifilarial agents.

Abstract: A process for the synthesis of adriamycin and 7,9-epiadriamycin, both active antineoplastic agents, in which 7-deoxydaunomycinone, in either the 9s or racemic (.+-.) form, is employed as the starting material, the process in one embodiment also being productive of the useful intermediate compound 4-methoxy-6,11-dihydroxy-7,8-dihydro-5,9(10H),12-naphthacenetrione. The process involves converting 7-deoxydaunomicinone successively to daunomycinone, adriamycinone, 14-0-p-anisyldiphenylmethyladriamycinone and finally to adriamycin or to both adriamycin and 7,9-epiadriamycin. When producing the latter mixture of diastereomers, the 7-deoxydaunomycinone starting material is first converted to racemate form by a process involving the successive production of 7-deoxydaunorubicinol, 4-methoxy-6,11-dihydroxy-7,8-dihydro-5,9(10H), 12-naphthacenetrione, (.+-.)-4-methoxy-9-cyano-6,9,11-trihydroxy-7,8,9,10-tetrahydro-5,12-naphth acenedione, (.+-.

Abstract: N-substituted 2-[2-(5-nitro-2-furyl)vinyl]imidazoles having the structure ##STR1## wherein R represents mono- or dimethoxybenzyl, pyridylmethyl, N,N-dimethylaminobenzyl or phenoxypropyl. A preferred compound is 1-(4-methoxybenzyl)-2-[2-(5-nitro-2-furyl)vinyl]imidazole. The compounds have utility as antischistosomal chemotherapeutic agents.

Abstract: Method and apparatus for the pollution-free generation of electrical power from carbonaceous fuels in which molten lead is electrochemically oxidized to produce lead oxide and electricity in a single integrated cell in which the resulting lead oxide is simultaneously converted back to lead metal by carbothermic reduction with a carbonaceous fuel, the entire process being carried out in a single cell using a molten carbonate as electrolyte in a temperature range of 500.degree. to 900.degree. C. The entire cycle thus consumes only carbon and oxygen and produces electricity. It is found that by thus coupling the electrochemical cell and the thermochemical regeneration system, the resulting integrated carbon-lead-air cell will maintain a voltage well above that provided by a simple lead-air cell approaching that of a hypothetical carbon-air cell.