Abstract: Chimeric analogs of calicheamicin that include an analog of calicheamicinone linked to an ester or glycoside, (-)-calicheamicinone and its analogs are disclosed.
Type:
Grant
Filed:
July 16, 1992
Date of Patent:
November 23, 1993
Assignee:
The Scripps Research Institute
Inventors:
Kyriacos C. Nicolaou, Adrian L. Smith, Chan-Kou Hwang, Emmanuel Pitsinos