Abstract: A ceramic cutting insert, including a face ground top surface, and at least one peripheral clearance surface adjacent to an edge, from which a reinforcing chamfer surface extends inward. The chamfer surface forms a first acute angle with a reference plane that is parallel to the top surface. A generally concave unground intermediate surface is formed between the top surface and the chamfer surface, the intermediate surface at the transition to the top surface forming a second angle with the top surface that is greater than the first angle, and the width of the chamfer surface being greater than the width of the intermediate surface.

Abstract: A holder block is mounted on a carrier and has formed therein a first hole and a water passage. A sleeve is mounted in the first hole and receives a cutter bit. The sleeve includes a shank and an enlarged flange disposed at a front end thereof. The shank is disposed in the first hole. The flange includes a rearwardly facing shoulder bearing against an outer surface of the block. A second hole extends through the shank and the flange and is adapted to receive the cutter bit. A spray nozzle is disposed in the flange and is connected to the water passage by way of an annular groove, for receiving water which it sprays forwardly against the cutter bit.

Abstract: The present invention relates to the discovery that signaling via a serotonin type 1B, 2, 4 and 6 receptor is important in T cell activation such that inhibiting such signaling can be used to modulate the immune response. This immunomodulation is useful for the treatment of immune diseases or conditions, and for the development of potential therapeutics for such diseases or conditions. It has been further discovered that, in cells proceeding through the cell cycle process, inhibition of serotonin signaling inhibits the process and induces apoptosis and morphological changes to a cell. These effects of inhibiting serotonergic signaling can be useful for effecting selective cell killing and for identifying compounds that inhibit the signaling.

Abstract: Two-chain high molecular weight kininogen, and peptide analogs thereof having homology to sites within kininogen domain 5, are potent inhibitors of angiogenesis. The peptides have the formula X1-His-Lys-X-Lys-X2 wherein X is any amino acid, X1 is from zero to twelve amino acids, more preferably from zero to six amino acids, most preferably from zero to three amino acids, and X2 is from zero to twelve amino acids, more preferably from zero to six amino acids, most preferably from zero to three amino acids. X is preferably an amino acid having a nonpolar side chain, or a polar side chain which is uncharged at pH 6.0 to 7.0. X is most preferably Asn, Phe or His. Methods of inhibiting endothelial cell proliferation and angiogenesis are provided.