Abstract: A group of functionalized polyaminocarboxamide modified chelators, such as 1,4 7,10-tetraaza-1-N-(1-carboxy-3-(4-aminophenyl)propyl)-7-N-(1-carboxymethyl )bis-4,10-N,N-(carboxamidomethyl)cyclododecane and 1,4 7,10-tetraaza-1-N-(1-carboxy-3-(4-aminophenyl)propyl)bis-4,7-N,N-(1-carbox ymethyl)-10-N-(carboxamidomethyl)cyclododecane are disclosed. These modified chelators are capable of forming complexes with rare earth-type metal ions. When the complexes are covalently attached to an antibody or antibody fragment, they can be used in therapeutic and diagnostic applications.
Type:
Grant
Filed:
April 13, 1995
Date of Patent:
April 14, 1998
Assignee:
The Dow Chemical Company
Inventors:
William J. Kruper, Jr., William A. Fordyce, A. Dean Sherry
Abstract: A novel intermediate useful in the synthesis of 2-hydroxyethyl iminodiacetic acid is disclosed. The intermediate can be formed by contacting 2-hydroxyethyl amine with glycolonitrile to form an aminonitrile which can be hydrolyzed and contacted with additional glycolonitrile to form the nitrile intermediate which can be converted to 2-hydroxylethyl iminodiacetic acid via hydrolysis.
Type:
Grant
Filed:
October 31, 1996
Date of Patent:
March 10, 1998
Assignee:
The Dow Chemical Company
Inventors:
Phillip S. Athey, Druce K. Crump, David A. Wilson
Abstract: A method for the preparation of concentrated, stable iron chelate solutions of alkali metal polyamino disuccinic acids is disclosed. The method involves the controlled addition of the alkaline alkali-metal succinate solution to an agitated aqueous ferric salt solution.
Abstract: Aminosuccinic acid chelants are disclosed which have been found to be applicable in photographic processes. The aminosuccinic acids can be used in a method of bleaching or bleach-fixing a silver halide photographic material comprising contacting the photographic material with a bleaching solution containing at least one metal complex of a polyamino disuccinic acid and one or more metal complexes of a polyamino monosuccinic acid or a monoamino monosuccinic acid.
Type:
Grant
Filed:
January 14, 1997
Date of Patent:
November 25, 1997
Assignee:
Eastman Kodak Company
Inventors:
David A. Wilson, Druce K. Crump, Eric R. Brown
Abstract: Aminosuccinic acid chelants are disclosed which have been found to be applicable in photographic processes. The aminosuccinic acids can be used in a method of bleaching or bleach-fixing a silver halide photographic material comprising contacting the photographic material with a bleaching solution containing at least one metal complex of a polyamino disuccinic acid and one or more metal complexes of a polyamino monosuccinic acid or a monoamino monosuccinic acid.
Type:
Grant
Filed:
August 30, 1995
Date of Patent:
July 29, 1997
Assignee:
Eastman Kodak Company
Inventors:
David A. Wilson, Druce K. Crump, Eric R. Brown
Abstract: Polyamino monosuccinic acid chelants are disclosed which have been found to be applicable in photographic processes. The polyamino monosuccinic acids can be used in a method of bleaching or bleach-fixing a silver halide photographic material comprising contacting the photographic material with a bleaching solution containing a metal complex of a polyamino monosuccinic acid as a bleaching agent.
Type:
Grant
Filed:
August 30, 1995
Date of Patent:
December 17, 1996
Assignee:
Eastman Kodak Company
Inventors:
Alan D. Strickland, David A. Wilson, Eric R. Brown
Abstract: Adding at least one biotransformation enhancing agent selected from the group consisting of propylene glycol, glycerol, glutamate, a mixture of proteose peptone, beef extract, yeast extract, malt extract, dextrose and ascorbic acid and, and mixtures thereof to halogenated hydrocarbon contaminated soil and/or water.
Abstract: The invention concenrs giant ring compounds containing about 20 to about 160 atoms in the backbone of the ring and methods for preparing the giant ring compounds.
Abstract: A process for converting halogenated aliphatic hydrocarbons to halohydrins using a microorganism selected from Rhodococcus species ATCC 55388 and mutants thereof are described.
Abstract: The invention relates to a novel process to prepare selectively mono-N-alkylated polyazamacrocycles which requires an electrophile with between about one and five equivalents of a suitable macrocycle in a solvent which will not promote a proton transfer.
Abstract: Radiolabeled colloid compositions and a method for the preparation of radionuclide-colloid compositions useful in the treatment of rheumatoid arthritis are disclosed. A radionuclide selected from the group consisting of Sm-135, Ho-166, In-155m, Y-90, Gd-159 La-140, Lu-177, or Yb-175 is sorbed to a previously prepared iron-hydroxide colloid. The radiolabeled colloid compositions are comprised of spherical aggregations containing greater than 50% of the radioactive metal in iron-hydroxide particles. The method produces stable radionuclide iron-hydroxide compositions which are useful in therapeutic procedures such as radiation synovectomy.
Type:
Grant
Filed:
December 27, 1989
Date of Patent:
October 29, 1991
Assignee:
The Dow Chemical Company
Inventors:
Jaime Simon, Lance A. Cooper, Kenneth McMillan, David A. Wilson