Abstract: Anti-estrogenic cyclopropyl analogs such as 1,1-dichlorocis-2,3-diphenylcyclopropane, when administered to a subject function as anti-tumor agents to prevent the development of estrogen-dependent tumors in the subject and substantially arrest the growth and metastatic involvement of existing estrogen-dependent tumors in the subject. Further, the anti-estrogenic cyclopropyl analogs may be used as anti-estrogenic agents and as fertility agents in the treatment of female infertility. The cyclopropyl analogs useful as anti-tumor, anti-estrogenic and female fertility agents have the general structure ##STR1## wherein: X is a halogen or hydrogen atom;R.sub.1 is a hydrogen atom, an alkyl group containing from 1 to about 3 carbon atoms, a monocyclic group, a hydroxy substituted monocyclic group, an alkoxy substituted monocyclic group in which the alkyl substituent contains from 1 to about 3 carbon atoms or an acetoxy substituted monocyclic group;R.sub.
Type:
Grant
Filed:
September 21, 1987
Date of Patent:
November 7, 1989
Assignee:
The Board of Regents for the University of Oklahoma
Abstract: A target illuminating aiming system, for use with a firing weapon in reduced lighting, is provided with a light assembly for generating light and a light focusing assembly for directing the light generated by the light assembly at a target area into a first zone and a second zone. The second zone generally overlies the first zone and provides sufficient illumination of the target area such that an individual firing the weapon is better able to identify the target area. The first zone is alignable with the trajectory of a projectile fired form the weapon such that the projectile impacts in or near that portion of the target defined by the first zone.
Abstract: The present invention comprises a thread dyeing apparatus and method for dyeing a thread. The apparatus comprises a marker having a transorb material and a nib with dyeing liquid being disposed in the marker housing as passing through the transorb material to the nib. A slit is formed in the nib. The slit is sized so the thread extends through the slit in the nib wherein the dyeing liquid is applied to the thread. In one embodiment, the apparatus is used to dye thread during operation of a sewing machine and, in this embodiment, the marker is positioned between the thread source and the needle of the machine. In other embodiment, the apparatus is utilized for applying a thread lubricant to the thread.
Type:
Grant
Filed:
April 19, 1988
Date of Patent:
October 24, 1989
Assignee:
Rhema Enterprises, Inc.
Inventors:
Earl Kinnebrew, II, Paul D. Palmer, Sr.
Abstract: A method of detecting the presence of first antibodies against a chorionic gonadotropin-like substance in a first biological sample obtained from an organism other than domestic poultry. The first biological sample is contacted with a chorionic gonadotropin-like substance, preferably isolated from Progenitor cryptocides microorganism, which has been immobilized on a solid phase, under conditions permitting first antibody/chorionic gonadotropin-like substance binding. Unbound sample components are removed from the solid phase, and a plurality of second antibodies, each comprising an immunological conjugate of the first antibody, are contacted with the solid phase, under conditions permitting second antibody/first antibody binding. Unbound second antibodies are removed from the solid phase and the presence of chorionic gonadotropin-like substance/first antibody/second antibody complex, if any, is observed, as a measure of the presence of first antibodies in the first biological sample.
Abstract: A swing check valve having a readily replaceable valve seat and having a cage surrounding the disc in the final closing movement of the disc sized to guide the disc evenly onto the seat.
Abstract: A swing check valve having a readily replaceable valve seat and having a cage surrounding the disc in the final closing movement of the disc sized to guide the disc evenly onto the seat.
Abstract: A trap for capturing crawling insects is provided. The trap includes a cylindrical outer housing, a container slidably inserted within the outer housing and a conical entrant lid is detachably secured to the upper end of the container. The outer housing is positioned in the ground such that when the container is inserted therein, the conical entrant lid is substantially level with the ground. Insects traversing the conical entrant lid cascade into the container and are retained therein. The trap also includes a lifting ball pivotally secured to the container for removing the container from the outer housing.
Abstract: A swing check valve having a readily replaceable valve seat and having a cage surrounding the disc in the final closing movement of the disc sized to guide the disc evenly onto the seat.
Abstract: A swing check valve having a readily replaceable valve seat and having a cage surrounding the disc in the final closing movement of the disc sized to guide the disc evenly onto the seat.
Abstract: A riding apparatus, such as a water ski board or snow ski board, in which the rider's feet are positionable within bindings formed on first and second riding plates. Each riding plate is positionable above a channel section formed within a rider support surface of the riding apparatus. Fasteners supported by each riding plate are releasably engageable with retaining elements installed within the channel section. After loosening the fasteners from the retaining elements, each riding plate may be repositioned angularly or longitudinally with respect to its channel section, thereby permitting the apparatus to be used with a variety of stances and leg spacings.
Abstract: A porch adapted for use with a mobile living unit. The porch is moveable from a traveling position wherein the base is disposed generally under the mobile living unit to a support position wherein the base extends a distance from one side of the mobile living unit.
Abstract: A continuously variable transmission having pulleys mounted on parallel input and output shafts and an endless belt engaging both pulleys for power transmission from the input shaft to the output shaft. The pulley on the output shaft is split into axially spaced halves having facing conical surfaces for variation of the radius at which the belt engages such pulley. One or both halves of the pulley on the output shaft have threaded bores mating with threaded portions of the output shaft.
Abstract: A system for testing the conditions of at least one pair of contacts to determine if the contacts are opened or closed comprising a transmit circuit and a receive circuit. The transmit circuit generates and outputs a test signal having a known frequency and the test signal is optically coupled to the contacts. The receiving circuit receives the test signal from the contacts and outputs one output indication indicating the contacts are closed in response to receiving the test signal and outputs one other indication indicating the contacts are opened in resposne to not receiving the test signal. The receiving circuit also optically couples the test signal from the contacts to the indicating means.
Abstract: An apparatus adapted for use with a plurality of cable pairs for placing a test condition on a selected cable pair including a cable pair tester and means remote from the cable pair tester for supplying a cable pair command code and a test condition command code. The cable pair tester includes a portion connected to each of the cable pairs with electrical continuity being interrupted between the cable pairs and the cable pair tester. The cable pair tester is adapted to establish electrical continuity between a selected one of the cable pairs and the cable pair tester in response to receiving a cable pair command code uniquely identifying the selected cable pair. The cable pair tester places the test condition on the selected cable pair in response to receiving the test condition command code.
Abstract: A disc for a swing check valve where the body of the disc and the hinge pins are cast as one piece to facilitate the alignment of the hinge pins with the sealing face of the disc. The swing radius of the disc is at a minimum and a spring closure is provided.
Abstract: A swing check valve where the hinge pin of the disc is supported by an insert separate from the valve seat and/or valve cage. The hinge pin insert is readily replaceable.
Abstract: A swing check valve for use between flanges wherein the valve seat and cage for the valve disc extend from the upstream to the downstream ends of the valve body. Cooperating shoulders are provided in the valve body and the member forming the seat and cage to prevent upstream movement of these members in the valve body, and downstream movement is prevented by plate-like members fitting in recesses in the cage portion and the valve body bore.