Patents Represented by Attorney Dwayne L. Bentley
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Patent number: 7472928Abstract: A connector is provided for selectively coupling one or more lines or wires (19?, 19?) to a receiving and/or transporting device (27). The connector comprises at least one line or wire receiving ferrule (7) having a plurality of line and/or wire receiving holes (17?-17?) each capable of receiving one of said one or more lines or wires (19?, 19?), wherein said connector further comprises a body (3) for receiving said ferrule (7) and clamping means (9, 11) for exerting a force on said ferrule (7) in order to simultaneously exert a line or wire clamping force on all said line and/or wire receiving holes (17?-17?). In this way all the fluid lines or wires can be clamped at the same time.Type: GrantFiled: October 31, 2007Date of Patent: January 6, 2009Assignee: GE Healthcare Bio-Sciences ABInventors: Owe Salven, Mattias Vangbo, Patrik Kallback, Marten St Jernstrom
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Patent number: 7473877Abstract: The invention relates to a method for adjusting focus in an automated microscope. The method may comprise the steps of: providing an optical detector for image acquisition, wherein the optical detector comprises an array of sensor pixels; designating a region of interest in the array of sensor pixels to emulate a confocal aperture; directing a light beam to illuminate an object according to a predefined pattern, thereby forming an image of the illuminated pattern at the optical detector, wherein the image of the illuminated pattern substantially overlaps the designated region of interest; detecting a light intensity from sensor pixels located within the designated region of interest; and adjusting a relative focal position of an objective lens based on the detected light intensity.Type: GrantFiled: October 31, 2007Date of Patent: January 6, 2009Assignee: General Electric CompanyInventor: Pavel A. Fomitchov
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Patent number: 7469056Abstract: A system for performing automated cell screening in drug discovery, including an automated microscope, a fast autofocus device and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.Type: GrantFiled: May 9, 2003Date of Patent: December 23, 2008Assignee: GE Healthcare Niagara Inc.Inventors: Peter Ramm, Yuriy Alexandrov, Jurich Cybuch, Paul Donders, Carlos Zarate, Bohdan J. Soltys
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Patent number: 7460236Abstract: A method of examining thin layer structures on a surface for differences in respect of optical thickness, which method comprises the steps of: irradiating the surface with light so that the light is internally or externally reflected at the surface; imaging the reflected light on a first two-dimensional detector; sequentially or continuously scanning the incident angle and/or wavelength of the light over an angular and/or wavelength range; measuring the intensities of light reflected from different parts of the surface and impinging on different parts of the detector, at least a number of incident angles and/or wavelengths, the intensity of light reflected from each part of the surface for each angle and/or wavelength depending on the optical thickness of the thin layer structure thereon; and determining from the detected light intensities at the different light incident angles and/or wavelengths an optical thickness image of the thin layer structures on the surface.Type: GrantFiled: August 15, 2007Date of Patent: December 2, 2008Assignee: GE Healthcare Bio-Sciences ABInventor: Bengt Ivarsson
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Patent number: 7452464Abstract: A chromatography column having a longitudinal axis and comprising a column wall with a first end and a second end, a first end plate assembly removably connectable to said first end of the column wall, a second end plate assembly removably connectable to said second end of the column wall, wherein said first end plate assembly, said column wall and said second end plate assembly are arranged along the longitudinal axis of the column wherein the column wall, and/or first end plate assembly and/or second end plate assembly is/are rotatable about an axis of rotation wherein said axis of rotation is parallel to the longitudinal axis of said column and positioned outside the column.Type: GrantFiled: July 18, 2005Date of Patent: November 18, 2008Assignee: GE Healthcare Bio-Sciences ABInventors: Per Uselius, Mats Olsson, Sven Wounder, Jerker Persson
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Patent number: 7452471Abstract: A column packing system comprises a control unit provided with software for monitoring the column interior pressure and/or flow through the column for use in calculating the breakpoint where a movable adapter comes into contact with a consolidated bed of bed media. The calculated breakpoint is used by the control unit to determine how much further the movable adapter has to move into the column in order to achieve a desired amount of bed compression.Type: GrantFiled: October 21, 2005Date of Patent: November 18, 2008Assignee: GE Healthcare Bio-Sciences ABInventor: Kristian Windahl
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Patent number: 7442342Abstract: A biochip holder is disclosed, the holder including a means to receive a biochip, a vacuum port in communication with the received biochip, and a vacuum source connected to the vacuum port. Liquid from flushing of the biochip is pulled by vacuum force into a vacuum port and can be collected in order to prevent cross-contamination of the biochip. A method of collecting fluid from such a biochip is also disclosed.Type: GrantFiled: June 26, 2002Date of Patent: October 28, 2008Assignee: GE Healthcare Bio-Sciences ABInventors: Clifford L. Anderson, Roberta L. Druyor-Sanchez, Roy Taylor Mast, Sangeet Singh-Gasson
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Patent number: 7419599Abstract: A column packing system comprises a control unit provided with software for calculating the breakpoint where a movable adapter comes into contact with a settled bed of bed media. The calculated breakpoint is used by the control unit to determine how much further the movable adapter has to move into the column in order to achieve a desired amount of bed compression.Type: GrantFiled: July 12, 2005Date of Patent: September 2, 2008Assignee: GE Healthcare Bio-Sciences ABInventors: Torvald Andersson, Mats Olsson, Bengt Asberg, Lars Andersson
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Patent number: 7409250Abstract: A method and an apparatus for the development of a control process for an instrument are disclosed. The method comprises a first step of selecting one or more commands from a plurality of pre-defined commands in which at least one of the selected one or more commands being a purpose-linked command; and a second step of combining the selected one or more commands to produce the control process. The pre-defined commands have a control part for controlling the operation of the instrument and at least one of the pre-defined commands has a purpose part for controlling the purpose of the command.Type: GrantFiled: December 6, 2004Date of Patent: August 5, 2008Assignee: GE Healthcare Bio-Sciences ABInventors: Johan Arthursson, Helen Bäckgren, Patrik Berglund, Francis Markey, Annika Remaeus, Karl Andersson, Pär Säfsten, Fredrik Edebratt
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Patent number: 7369696Abstract: A method of classifying cells into subpopulations using cell classifying data is described. The method comprises receiving and analyzing image data to identify object areas in the image data to determine, for at least one selected first cell, one or more measurements. A first parameter set is derived from the measurements for the first cell, the first parameter set comprising at least one of said one or more measurements. The first set of cells are classified into subpopulations, and identified to produce first identifying data. Cell classifying data for use in classifying a second set of cells into subpopulations is derived from the first parameter set and the first identifying data. A second set of cells is classified into subpopulations on the basis of one or more measurements taken for cells in the second set of cells, by use of the cell classifying data. The parameter sets of cells may be represented as vectors in an n-dimensional space.Type: GrantFiled: April 2, 2004Date of Patent: May 6, 2008Assignee: GE Healthcare UK LimitedInventors: Nick Arini, Alla Zaltsman, Ian Goodyer, Yuriy Alexandrov, Jurek Cybuch, Bohdan Soltys, Louis Dagenais, Liz Roquemore, Sam Murphy
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Patent number: 7361308Abstract: The present invention relates to devices and methods for removing gels plugs (47) from a gel(3) bonded to a surface (5) wherein means are provided for rotating the gel plug before lifting it from said surface. The rotation of the gel plug is intended to break the bond between said gel plug and said gel surface.Type: GrantFiled: June 29, 2001Date of Patent: April 22, 2008Assignee: GE Healthcare Bio-Sciences ABInventor: Lars Fagerstam
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Patent number: 7341202Abstract: Method and device for continuously producing a coherent layer of a liquid/melt of even thickness by means of centrifugal action along the entire periphery of a rotating disk (13, 113), liquid/melt being supplied to the disk around its entire axis of rotation from means (12, 112) and leaving the disk as individual droplets. The means (12, 112) distributing the liquid/melt onto the disk (13, 113) has according to the invention essentially the same speed and direction of rotation as the disk, and the liquid/melt undergoes under the influence of centrifugal action circumferentially a spreading and change in velocity across the disk (13, 113) in contact with the same.Type: GrantFiled: December 15, 2004Date of Patent: March 11, 2008Assignee: GE Healthcare Bio-Sciences ABInventors: Ralf Goran Andersson, Ingemar Jonsson
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Patent number: 7335898Abstract: A new and improved confocal fluorescence microscope is presented. The new microscope has significant advantages relative to existing implementations of microscope confocal imagers. In common with previous confocal imagers the instant invention has the advantages relative to conventional wide-field and confocal fluorescence imagers, however it addresses the drawbacks of confocal technology in terms of cost and complexity, and provides significant savings in both due to the simplicity of the components and the elimination of the need of, in particular, spatial filters such as pinholes or slits.Type: GrantFiled: July 19, 2005Date of Patent: February 26, 2008Assignee: GE Healthcare Niagara Inc.Inventors: Paul Donders, Carlos Zarate, Pavel A. Fomitchov
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Patent number: 7312443Abstract: A reflectron (109) is provided with at least two sets of field resistances (131a-131n, 137a-137n) which may be connected together or separately to the reflectron electrodes (123a-123n) in order to be able to provide a plurality of different shaped electrical fields inside the reflectron (109).Type: GrantFiled: November 19, 2003Date of Patent: December 25, 2007Assignee: GE Healthcare Bio-Sciences ABInventor: Jan Axelsson
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Patent number: 7301166Abstract: Multiplexer for electromagnetic radiation, e.g. UV-light, in which a single electromagnetic radiation source (203) and a single electromagnetic radiation detector (223) are connectable in turn to a plurality of sample-containing units (207(a)-207(n)). The multiplexer comprises a sled (253) movable in relation to a fixed base (255) by an actuator (281).Type: GrantFiled: December 16, 2003Date of Patent: November 27, 2007Assignee: GE Healthcare Bio-Sciences ABInventors: Owe Salven, Stig Tormod
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Patent number: D567959Type: GrantFiled: September 18, 2007Date of Patent: April 29, 2008Assignee: GE Healthcare Bio-Sciences ABInventors: Alan M. Williams, Roger Nordberg
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Patent number: D569008Type: GrantFiled: December 20, 2007Date of Patent: May 13, 2008Assignee: GE Healthcare Bio-Sciences ABInventors: Roger Lundqvist, Dan Hermansson, Stefan D'Argy, Klaus Gebauer, Sven Wounder
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Patent number: D574499Type: GrantFiled: January 7, 2008Date of Patent: August 5, 2008Assignee: GE Healthcare Bioscience Bioprocess Corp.Inventor: Charles Lambalot
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Patent number: D584413Type: GrantFiled: January 7, 2008Date of Patent: January 6, 2009Assignee: GE Healthcare Bioscience Bioprocess Corp.Inventor: Charles Lambalot
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Patent number: D584821Type: GrantFiled: January 7, 2008Date of Patent: January 13, 2009Assignee: GE Healthcare Bioscience Bioprocess Corp.Inventor: Charles Lambalot