Patents Represented by Attorney Dwight E. Morrison
  • Patent number: 4400510
    Abstract: Antibiotic A-32256 which is produced by submerged, aerobic fermentation of a Streptomyces sp. NRRL 12067. The antibiotic has shown antibacterial activity against Staphylococcus and Streptococcus and various anaerobic species. In addition, the antibiotic has shown antitrichomonas activity in vitro, as well as activity for improving ruminant feed efficency and as a mosquito larvacide.
    Type: Grant
    Filed: September 21, 1981
    Date of Patent: August 23, 1983
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Marvin M. Hoehn
  • Patent number: 4375462
    Abstract: Antibiotic A-32724 complex, comprising microbiologically-active, related factors A, B and C, is produced by submerged, aerobic fermentation of a strain of Chaetomella raphigera Swift NRRL 12331. The A-32724 antibiotics are closely related antibiotics. The individual A-32724 factors are separated by chromatography. In addition to their antibacterial activity, the A-32724 factors inhibit certain enzymes and exhibit antihypertensive properties.
    Type: Grant
    Filed: September 16, 1981
    Date of Patent: March 1, 1983
    Assignee: Eli Lilly and Company
    Inventors: David H. Berg, Marvin M. Hoehn
  • Patent number: 4354971
    Abstract: Non-extractive process for the separation and purification of penicillin V from fermentation broth by addition of acid to acid-polished fermentation broth.
    Type: Grant
    Filed: June 22, 1981
    Date of Patent: October 19, 1982
    Assignee: Eli Lilly and Company
    Inventors: John M. Edmundowicz, Ernest E. Allanson
  • Patent number: 4342829
    Abstract: The new microorganism Streptomyces granuloruber, NRRL 12389 and the fermentation process for preparing narasin by submerged aerobic fermentation of this organism.
    Type: Grant
    Filed: May 6, 1981
    Date of Patent: August 3, 1982
    Assignee: Eli Lilly and Company
    Inventors: Ralph E. Kastner, Robert L. Hamil
  • Patent number: 4336333
    Abstract: Tunicamycin is produced by the cultivation of Streptomyces chartreusis Calhoun and Johnson, 1956, NRRL 12338. Methods of recovering tunicamycin and for separating and isolating individual factors A.sub.1, A.sub.2, B.sub.1, B.sub.2, C.sub.1, C.sub.2, D.sub.1 and D.sub.2 from tunicamycin complex are described.
    Type: Grant
    Filed: March 13, 1981
    Date of Patent: June 22, 1982
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Marvin M. Hoehn, LaVerne D. Boeck
  • Patent number: 4329472
    Abstract: Antibiotic A-33853 is produced by submerged, aerobic fermentation of a new Streptomyces sp. NRRL 12068. The antibiotic has shown antibacterial activity against Staphylococcus and Streptococcus species which are penicillin resistant. In addition, the antibiotic has shown antirival and antitrichomonal activity in vitro.
    Type: Grant
    Filed: April 13, 1981
    Date of Patent: May 11, 1982
    Assignee: Eli Lilly and Company
    Inventors: Marvin M. Hoehn, Karl H. Michel
  • Patent number: 4316959
    Abstract: Antibiotic A-32256 which is produced by submerged, aerobic fermentation of a Streptomyces sp. NRRL 12067. The antibiotic has shown antibacterial activity against Staphylococcus and Streptococcus and various anaerobic species. In addition, the antibiotic has shown antitrichomonas activity in vitro, as well as activity for improving ruminant feed efficency and as a mosquito larvacide.
    Type: Grant
    Filed: April 28, 1980
    Date of Patent: February 23, 1982
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Marvin M. Hoehn
  • Patent number: 4309504
    Abstract: The new microorganism Streptomyces lydicus DeBoer et al., NRRL 12034 and the fermentation process for preparing narasin by submerged aerobic fermentation of this organism.
    Type: Grant
    Filed: January 28, 1980
    Date of Patent: January 5, 1982
    Assignee: Eli Lilly and Company
    Inventors: Ralph E. Kastner, Robert L. Hamill
  • Patent number: 4293552
    Abstract: Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas, active as insecticides, and methods for their use as insecticides.
    Type: Grant
    Filed: July 31, 1979
    Date of Patent: October 6, 1981
    Assignee: Eli Lilly and Company
    Inventor: John L. Miesel
  • Patent number: 4293649
    Abstract: Antibiotic A-33853 is produced by submerged, aerobic fermentation of a new Streptomyces sp. NRRL 12068. The antibiotic has shown antibacterial activity against Staphylococcus and Streptococcus species which are penicillin resistant. In addition, the antibiotic has shown antiviral and antitrichomonal activity in vitro.
    Type: Grant
    Filed: February 21, 1980
    Date of Patent: October 6, 1981
    Assignee: Eli Lilly and Company
    Inventors: Marvin M. Hoehn, Karl H. Michel
  • Patent number: 4290798
    Abstract: This invention relates to a novel substituted thiadiazole, identified as 1-[5-(2-chloro-1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl]-1,3-dimethylurea, to its use in a novel method for the control of unwanted vegetation, and to a novel herbicidal composition employing the substituted thiadiazole as the herbicidally-active ingredient.
    Type: Grant
    Filed: November 29, 1978
    Date of Patent: September 22, 1981
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Tony Cebalo, Robert A. Walde
  • Patent number: 4283390
    Abstract: Antibiotic A-39183 complex, comprising microbiologically active, related factors A, B, C, D, and E, is produced by submerged, aerobic fermentation of a new microorganism Streptomyces sp., NRRL 12049. The A-39183 antibiotics are closely related antibiotics. The individual A-39183 factors are separated by chromatography. The A-39183 factors are antibacterial agents which have activity against Staphylococcus and Streptococcus species that are penicillin resistant. The A-39183 factors are also active against both gram-positive and gram-negative anaerobic bacteria, and are ionophores.
    Type: Grant
    Filed: November 1, 1979
    Date of Patent: August 11, 1981
    Assignee: Eli Lilly and Company
    Inventors: Kay F. Koch, Ralph E. Kastner
  • Patent number: 4259347
    Abstract: It has been discovered that fungal foliar phytopathogens may be controlled by the use of a broad class of 2,6-dinitroanilines. The fungicidally-effective compounds may bear a broad range of substituent groups on the anilino nitrogen and in the 3- and 4-positions of the benzene ring.
    Type: Grant
    Filed: April 26, 1979
    Date of Patent: March 31, 1981
    Assignee: Eli Lilly and Company
    Inventors: James R. Beck, Joseph A. Yahner
  • Patent number: 4259501
    Abstract: 3-Amino-5-(t-butyl)isoxazole, in optimum yield, is prepared in a stepwise manner by reacting a lower alkyl pivalate and acetonitrile in the presence of a base to yield pivalyl acetonitrile, which in turn is allowed to react with hydroxylamine under controlled conditions of pH to yield the desired compound. The compound is a useful intermediate for the preparation of isoxazole derivatives having utility as herbicides.
    Type: Grant
    Filed: December 7, 1978
    Date of Patent: March 31, 1981
    Assignee: Eli Lilly and Company
    Inventors: Kenneth W. Burow, Jr., Richard F. Eizember
  • Patent number: 4211870
    Abstract: Preparation of substituted 2-aminopyrazines by reaction of an .alpha.-chloro or .alpha.-bromo oxime with an aminoacetonitrile in the presence of an acid-uptake agent, followed by separation of the intermediate novel hydroxyimino-substituted aminoacetonitrile, and cyclization thereof with acid.
    Type: Grant
    Filed: April 6, 1979
    Date of Patent: July 8, 1980
    Assignee: Eli Lilly and Company
    Inventors: Charles J. Barnett, Thomas L. Emmick, Richard C. Hoying
  • Patent number: 4199525
    Abstract: Hydroxyimino-substituted aminoacetonitriles, intermediates in the preparation of substituted 2-aminopyrazines, which latter compounds are intermediates in the preparation of insecticidal benzoylpyrazinylureas.
    Type: Grant
    Filed: April 6, 1979
    Date of Patent: April 22, 1980
    Assignee: Eli Lilly and Company
    Inventor: Charles J. Barnett
  • Patent number: 4194899
    Abstract: There is disclosed a class of fluoroalkoxyphenyl-substituted nitrogen-containing heterocycles which are useful as herbicides, plant fungicides, and plant growth regulators. Internodal elongation of plants is inhibited by treatment with compounds of this invention.
    Type: Grant
    Filed: May 25, 1978
    Date of Patent: March 25, 1980
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Benefiel, Eriks V. Krumkalns
  • Patent number: 4192670
    Abstract: Novel compounds identified as acetal derivatives of 4-(substituted amino)-3,5-dinitrobenzaldehydes, effective as herbicides, and intermediates for their preparation.
    Type: Grant
    Filed: August 3, 1977
    Date of Patent: March 11, 1980
    Assignee: Eli Lilly and Company
    Inventor: Quentin F. Soper
  • Patent number: 4180568
    Abstract: It has been discovered that fungal foliar phytopathogens may be controlled by the use of a broad class of 2,6-dinitroanilines. The fungicidally-effective compounds may bear a broad range of substituent groups on the anilino nitrogen and in the 3- and 4-positions of the benzene ring.
    Type: Grant
    Filed: February 16, 1978
    Date of Patent: December 25, 1979
    Assignee: Eli Lilly and Company
    Inventors: James R. Beck, Joseph A. Yahner
  • Patent number: 4175087
    Abstract: .alpha.,.beta.-Unsaturated ketones and aldehydes, together with a method of preparation thereof which comprises reacting aldehydes and cyclic and acyclic ketones possessing a methyl or methylene group .alpha.- to the carbonyl function with N,N-dialkylformamide dialkyl acetal to yield the corresponding enaminoketones and enaminoaldehydes, which enaminoketones and enaminoaldehydes are allowed to react with alkyllithium reagents to yield the corresponding nitrogen-free 2-alkylidene ketones and 2-alkylidene aldehydes.
    Type: Grant
    Filed: January 12, 1978
    Date of Patent: November 20, 1979
    Assignee: Eli Lilly and Company
    Inventors: Riaz F. Abdulla, Kenneth H. Fuhr