Abstract: This disclosure describes novel compounds which are useful as precursors in the synthesis of 9-oxo-11.alpha.,16-dihydroxy-16-vinyl-5-cis-13-trans-prostadienoate esters which possess activity as hypotensive agents and/or as vasodilators.
Type:
Grant
Filed:
October 6, 1986
Date of Patent:
August 9, 1988
Assignee:
American Cyanamid Company
Inventors:
Allan Wissner, Kenneth E. Green, Philip R. Hamann, Jeremy Levin
Abstract: This disclosure describes compositions of matter containing certain substituted imidazo[1,5-d]-1,2,4-triazin-1(2H)-ones and the method of treating hypertension therewith.
Abstract: This disclosure describes novel 6-(4-substituted-1-piperazinyl)-5,8-quinolinediones, 7-(4-substituted-1-piperazinyl)-5,8-quinolinediones, and 6-(4-substituted-1-piperazinyl)-5,8-quinoxalinediones which possess activity as anti-asthmatic and anti-allergic agents.
Abstract: This disclosure describes continuous epimerization-crystallization process for the isolation of [S-(R*, S*)]-1-(3-acetylthio-3-benzoyl-2-methylpropionyl)-L-proline from a diasteromeric mixture thereof with [S-(R*, R*)]-1-(3-acetylthio-3-benzoyl-2-methylpropionyl)-L-proline.
Type:
Grant
Filed:
June 28, 1982
Date of Patent:
March 27, 1984
Assignee:
American Cyanamid Company
Inventors:
Sivaraman Raghu, Robert J. Proverb, Steven L. Peake
Abstract: This disclosure describes novel 1,4,-bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof, useful as chelating agents and for inhibiting the growth of transplanted mouse tumors. This disclosure also describes compositions of matter useful as inhibitors of transplanted mouse tumor growth and the method of inducing the regression and/or palliation of leukemia and related cancers in mammals therewith.
Abstract: This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the novel active ingredients of said compositions of matter being the pharmacologically acceptable cationic salts of benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile, or mixtures thereof.
Type:
Grant
Filed:
May 9, 1978
Date of Patent:
April 8, 1980
Assignee:
American Cyanamid Company
Inventors:
Adolph E. Sloboda, John W. Hanifin, Jr.