Abstract: This disclosure describes continuous epimerization-crystallization process for the isolation of [S-(R*, S*)]-1-(3-acetylthio-3-benzoyl-2-methylpropionyl)-L-proline from a diasteromeric mixture thereof with [S-(R*, R*)]-1-(3-acetylthio-3-benzoyl-2-methylpropionyl)-L-proline.
Type:
Grant
Filed:
June 28, 1982
Date of Patent:
March 27, 1984
Assignee:
American Cyanamid Company
Inventors:
Sivaraman Raghu, Robert J. Proverb, Steven L. Peake
Abstract: This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the novel active ingredients of said compositions of matter being the pharmacologically acceptable cationic salts of benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile, or mixtures thereof.
Type:
Grant
Filed:
May 9, 1978
Date of Patent:
April 8, 1980
Assignee:
American Cyanamid Company
Inventors:
Adolph E. Sloboda, John W. Hanifin, Jr.