Abstract: A method for forming vesicles is described, wherein a lipid coating is formed onto a deformable surface. During hydration, the lipid coating is fragmented by deformation of the surface. The resulting fragments of the lipid coating are dispersed in the hydrating medium, so as to be subjected to multidirectional hydration, whereby formation of vesicles is accelerated. In the preferred embodiment, such surface is defined by a plurality of water-swellable particles formed of a polymeric material.