Abstract: A system with a pair of flange extrusions and a base extrusion having a channel for electrical leads and lighting. A preferred embodiment has a base extrusion of polyvinyl chloride (PVC) of 89–98 Duro on the Shore OO scale. The base extrusion is connected, on opposite sides of the channel, to a first flange extrusion and a second flange extrusion of PVC with a hardness of preferably of 90 Duro. Electrical leads are placed in the channel. A lens is inserted into the channel over the leads. A replaceable LED module having a circuit board secured to a module base is attached to the leads. The circuit board preferably has a gasket or seal, an LED and two contact teeth that make electrical contact with the leads.

Abstract: The present invention is a soft light fixture. In particular, it is an LED soft light fixture. The preferred embodiment of the soft light fixture has a plurality of light emitting diodes mounted on a perimeter ring aimed to emit light into a light-mixing chamber. The perimeter ring supports a light deflection cap with a lens, preferably translucent. The ring, deflection cap and lens define the light mixing chamber which blends light from the plurality of light emitting diodes into a single light source.

Abstract: The present invention is a ground-embedded, air-cooled lighting device. In particular, the present invention is directed to a floodlight or sealed lamp. A preferred embodiment of the floodlight comprises a sealed casing having an exterior wall and contains air. The sealed casing holds a disc element supporting a translucid material and a tube spaced from the exterior wall. The tube is preferably concentrically mounted within the casing. The tube surrounds an optical reflector, a light source mounted at the reflector's focus and aimed at the disc element, and a power supply for the light source. The sealed casing further contains a fan, preferably aimed a portion of the exterior wall having increased thermal conductivity. The fan circulates air in the casing through the tube and past the disc element for cooling purposes.

Abstract: The present invention is an improved earpiece light. In particular, the present invention is directed to an earpiece having a power supply and a light source mounted on the earpiece. The earpiece light is preferably for use on a person's outer ear. The earpiece light comprises an ear support, preferably for placement behind the user's crest of helix. The ear support is attached to a power supply housing, preferably for placement over the user's external auditory canal. The power supply housing has a power supply and a lamp arm with a distal end extended from the power supply housing. The power supply is connected to a light source mounted on the distal end of the lamp arm. Preferably, the lamp arm is positioned below the ear support and the power supply is connected to a light source, preferably an LED, mounted on the lamp arm.

Abstract: The present invention is an intrinsically safe pneumatically actuated flow controller. A preferred embodiment for the flow controller has a housing assembly defining an inlet port, an outlet port, a pressure signal inlet port, and a main flow path extending between the inlet port and the outlet port. A restriction member is arranged in the main flow path. A first valve assembly and second valve assembly control fluid flow along the main flow path. A first regulator assembly operates the first valve assembly. A pressure signal actuation assembly has an actuation bellows attached to an actuation piston mounted on a flow control piston rod that passes through an isolation plate and is sheathed by an isolation bellows. The flow control piston rod terminates in a flow control piston that engages a second regulator assembly, which operates the second valve assembly based on pressure signals transmitted through the pressure signal inlet to the pressure signal actuation assembly.

Abstract: The present invention generally relates to a lighting fixture where individual light sources can be removed and/or replaced from a strand of light sources. The preferred embodiment of the light fixture comprises a plurality of light sources strung together by a plurality of wire assemblies. Each light source preferably has one end of a tongue and groove connector where the opposing end of the connector is attached to an end of a wire assembly. The strand of light sources is then placed within a lens component, preferably an extrusion. The lens component is connected to a base component; wherein the plurality of light sources are mounted to the base component and contained within the lens component. The fixture can be mounted to, inter alia, a wall, a chair, or a railing in an area to be lit by the fixture.

Abstract: The present invention is an improved earpiece light. In particular, the present invention is directed to an earpiece having a power supply and a light source mounted on the earpiece. The earpiece light is preferably for use on a person's outer ear. The earpiece light comprises an ear support, preferably for placement behind the user's crest of helix. The ear support is attached to a power supply housing, preferably for placement over the user's external auditory canal. The power supply housing has a power supply and a lamp arm with a distal end extended from the power supply housing. The power supply is connected to a light source mounted on the distal end of the lamp arm. Preferably, the lamp arm is positioned below the ear support and the power supply is connected to a light source, preferably an LED, mounted on the lamp arm.

Abstract: A flow controller having a first and second stages of regulation. The first stage is a pressure regulation stage that maintains the pressure within an intermediate chamber (formed by a series of interconnected passageways and cavities) within a predetermined range above the pressure in an outlet port. The second stage maintains the flow rate within a predetermined range about a target flow rate. Both stages sample the pressure in the outlet port and automatically adjust the flow of fluid to ensure that fluctuations in pressure at the inlet and outlet ports do not affect the flow rate. The flow rate is set and controlled by a user determined setpoint. The pressure is regulated by one or more feedback systems. The feedback systems used may be mechanical or electromechanical based on a particular operating environment.

Abstract: A flow meter system that calculates mass flow rate based only on a single pressure signal. A flow controller is arranged in parallel with a restriction such that it constant pressure differential is maintained across the restriction. The pressure, and temperature if not controlled, of the fluid flowing through the restriction is measured on either side of the restriction. The pressure is compared to a plot of pressure versus mass flow rate calculated for the specific restriction and fluid being measured. The constant pressure differential maintained across the restriction yields a linear relationship between pressure and flow rate. If temperature is not controlled, the plot or pressure versus mass flow rate will remain linear, but the slope of the curve will be adjusted based on the temperature of the fluid.

Abstract: A flow meter system that calculates mass flow rate based only on a single pressure signal. A flow controller is arranged in parallel with a restriction such that a constant pressure differential is maintained across the restriction. The pressure, and temperature if not controlled, of the fluid flowing through the restriction is measured on either side of the restriction. The pressure is compared to a plot of pressure versus mass flow rate calculated for the specific restriction and fluid being measured. The constant pressure differential maintained across the restriction yields a linear relationship between pressure and flow rate. If temperature is not controlled, the plot of pressure versus mass flow rate will remain linear, but the slope of the curve will be adjusted based on the temperature of the fluid.

Abstract: A flow meter system that calculates mass flow rate based only on a single pressure signal. A flow controller is arranged in parallel with a restriction such that a constant pressure differential is maintained across the restriction. The pressure, and temperature if not controlled, of the fluid flowing through the restriction is measured on either side of the restriction. The pressure is compared to a plot of pressure versus mass flow rate calculated for the specific restriction and fluid being measured. The constant pressure differential maintained across the restriction yields a linear relationship between pressure and flow rate. If temperature is not controlled, the plot of pressure versus mass flow rate will remain linear, but the slope of the curve will be adjusted based on the temperature of the fluid.

Abstract: The present invention provides isolated nucleic acids encoding alpha9 nicotinic acetylcholine receptor subunit and receptor subunit protein encoded thereby. Also provided are vectors containing the invention nucleic acids, host cells transformed therewith, alpha9 nicotinic acetylcholine receptor subunit and functional nicotinic acetylcholine receptors comprising at least one alpha9 subunit expressed recombinantly in such host cells as well as transgenic non-human mammals that express the invention receptor subunit and mutants thereof. Receptors of the invention comprise at least one alpha9 nicotinic acetylcholine subunit and form cationic channels activated by acetylcholine, but blocked by nicotine and muscarine. The invention also provides methods for identifying compounds that modulate the ion channel activity of the functional invention receptors containing at least one invention subunit.

Abstract: In accordance with the present invention, it has been discovered that monocyte conditioned medium (MCM) obtained from patients with liver disease stimulates the proliferation of fibroblasts. Platelet derived growth factor (PDGF) has also been found to stimulate fibroproliferation of fibroblasts, and to be at least partially responsible for the fibroproliferative effect of the MCM. Further in accordance with the present invention, the effect of MCM and PDGF on the expression of c-fos and c-jun has been investigated, because c-fos and c-jun form AP-1 complexes which can stimulate genes involved in proliferation. It has recently been reported that pentoxifylline inhibits platelet derived growth factor-stimulated proliferation. The mechanism of this action of pentoxifylline is unclear. Thus, in the course of the work undertaken as part of the present invention, studies were conducted to determine whether pentoxifylline altered the expression of c-fos and c-jun.

Abstract: The present invention provides novel cryptophycin compounds having the following structure: ##STR1## The present invention also provides methods for producing cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided by the present invention, as are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells. The present invention further provides methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.

Abstract: A method for modulating non-malignant skin related disorders in a subject has been demonstrated with 9-cis retinoic acid. Wrinkling, acne, keratinization, differentiation and proliferation disorders are treated by administration of 9-cis retinoic acid alone or in a pharmaceutically acceptable carrier to a subject in need thereof.

Abstract: In accordance with the present invention, novel retroviral vectors containing modified long terminal repeats (LTRS) which enable high level and ligand-modulatable expression of a desired gene product, even after prolonged periods of cellular quiescence, have been designed and constructed. Invention vectors overcome proviral transcriptional inactivation which occurs in cultured primary cells that are growth arrested due to environmental constraints such as contact inhibition and/or nutrient starvation. Invention vectors represent a class of retroviral vectors in which LTR-promoted proviral expression in infected cells may be maintained or increased, even in situations generally considered to be non-permissive for retroviral vectors.

Abstract: In accordance with the present invention, there are provided conjugates of nitric oxide scavengers (e.g., dithiocarbamates, or "DC") and pharmacologically active agents (e.g., NSAIDs). Invention conjugates provide a new class of pharmacologically active agents (e.g., anti-inflammatory agents) which cause a much lower incidence of side-effects due to the protective effects imparted by modifying the pharmacologically active agents as described herein. In addition, invention conjugates are more effective than unmodified pharmacologically active agents because cells and tissues contacted by the pharmacologically active agent(s) are protected from the potentially damaging effects of nitric oxide overproduction induced thereby as a result of the co-production of nitric oxide scavenger (e.g., dithiocarbamate), in addition to free pharmacologically active agent, when invention conjugate is cleaved.

Abstract: In accordance with the present invention, there are provided nucleic acids encoding human metabotropic glutamate receptor subtype mGluR6, and the proteins encoded thereby. In addition to being useful for the production of metabotropic glutamate receptor subtype mGluR6, nucleic acids of the invention are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits. In addition to disclosing a novel metabotropic glutamate receptor subtype, mGluR6, the present invention also comprises methods for using the invention receptor subtype to identify and characterize compounds which affect the function of such receptor subtype, e.g., agonists, antagonists, and modulators of glutamate receptor function.

Abstract: The retinoid X receptor (RXR) participates in a wide array of hormonal signaling pathways either as a homodimer or as a heterodimer with other members of the steroid/thyroid hormone superfamily of receptors. In accordance with the present invention, the ligand-dependent transactivation function of RXR has been characterized and the ability of RXR to interact with components of the basal transcription machinery has been examined. In vivo and in vitro experiments indicate the RXR ligand binding domain makes a direct, specific and ligand-dependent contact with a highly conserved region of the TATA binding protein (TBP). The ability of mutations that reduce ligand-dependent transcription by RXR to disrupt the RXR-TBP interaction in vivo and in vitro suggests that RXR makes direct contact with the basal transcription machinery in order to achieve activation.