Abstract: Certain novel N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
Type:
Grant
Filed:
July 15, 2005
Date of Patent:
November 17, 2009
Assignee:
Merck & Co., Inc.
Inventors:
Raman K. Bakshi, James P. Dellureficio, Ravi P. Nargund