Abstract: There are described pharmaceutical compositions comprising a lactone which is the 1,9-lactone, the 1,11-lactone, or the 1,15-lactone of a prostaglandin or prostaglandin analog in combination with a pharmaceutical carrier and formulated to deliver said prostaglandin or prostaglandin analog to an esterase-containing tissue area of a mammal. Also disclosed are methods for administering said compositions to a mammal.

Abstract: This invention is a group of prostaglandin-like compounds of the formula: ##STR1## wherein m is 0, 1, 2, or 3 and n is 2, 3, 4, or 5, wherein X and Y are --CH.sub.2 CH.sub.2 -- or X is cis-CH.dbd.CH-- and Y is --CH.sub.2 CH.sub.2 -- or cis--CH.dbd.CH--, and wherein R.sub.1 is hydrogen, alkyl of 1 to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with 1, 2, or 3 chloro or alkyl of 1 to 4 carbon atoms, inclusive, and the pharmacologically acceptable salts thereof when R.sub.1 is hydrogen. These compounds are useful as vasodepressors and antisecretory agents, and in managing cases of renal disfunction.

Abstract: Novel vaginal devices containing prostaglandins and intended for use in accomplishing abortion in women in the first and second trimester of pregnancy and in inducing labor in pregnant women at or near term.

Abstract: Prostaglandin A.sub.1 compounds with a methyl or an ethyl substituent at the C-15 position are disclosed. These are useful for the same pharmacological purposes as the unsubstituted prostaglandins A.

Abstract: The disclosure includes novel cyclic ethers of the formulas: ##STR1## In these formulas, X and Y are --O-- or a valence bond with the proviso that one of X and Y is --O-- and the other is a valence bond; R is hydrogen, alkyl of one to 4 carbon atoms; inclusive, or a pharmacologically acceptable cation; R.sub.2 and R.sub.3 are hydrogen, methyl, or ethyl; and A is ##STR2## wherein R.sub.4 is hydrogen, methyl, or ethyl with the proviso that R.sub.2 and R.sub.3 are both hydrogen when R.sub.4 is methyl or ethyl. The compounds of the first of these formulas are useful as vasoconstrictors and enhancers of platelet aggregation, and are useful in the control of bleeding in mammals, including man. The compounds of the second of these formulas are useful in the treatment of inflammation.

Abstract: A stable dosage form of PGE-type compounds is obtained by dissolving these compounds in triacetin.

Abstract: This invention is racemic PGE.sub.2, racemic PGF.sub.2.sub..alpha., racemic PGF.sub.2.sub..beta., racemic PGA.sub.2, racemic PGB.sub.2, analogs of those, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, abortion, and wound healing.

Abstract: The disclosure includes novel cyclic ethers of the formulas: ##SPC1##In these formulas, X and Y are --O-- or a valence bond with the proviso that one of X and Y is --O-- and the other is a valence bond; R is hydrogen, alkyl of one to 4 carbon atoms, inclusive, or a pharmacologically acceptable cation; R.sub.2 and R.sub.3 are hydrogen, methyl, or ethyl; and A is ##EQU1## wherein R.sub.4 is hydrogen, methyl, or ethyl with the proviso that R.sub.2 and R.sub.3 are both hydrogen when R.sub.4 is methyl or ethyl. The compounds of the first of these formulas are useful as vasoconstrictors and enhancers of platelet aggregation, and are useful in the control of bleeding in mammals, including man. The compounds of the second of these formulas are useful in the treatment of inflammation.

Abstract: Novel methods are disclosed for transforming PGA.sub.2 and 15.beta.-PGA.sub.2 and their acetates, methyl esters, and acetate methyl esters to various prostanoic acids and esters of the PGE.sub.2 and PGF.sub.2.sub..alpha. series. Some of the latter are novel and are useful for the same pharmacological purposes as PGE.sub.2 and PGF.sub.2.sub..alpha..

Abstract: Novel methods are disclosed for transforming PGA.sub.2 and 15.beta.-PGA.sub.2 and their acetates, methyl esters, and acetate methyl esters to various prostanoic acids and esters of the PGE.sub.2 and PGF.sub.2.sub..alpha. series. Some of the latter are novel and are useful for the same pharmacological purposes as PGE.sub.2 and PGF.sub.2.sub..alpha..

Abstract: Novel methods are disclosed for transforming PGA.sub.2 and 15.beta.-PGA.sub.2 and their acetates, methyl esters, and acetate methyl esters to various prostanoic acids and esters of the PGE.sub.2 and PGF.sub.2.sub..alpha. series. Some of the latter are novel and are useful for the same pharmacological purposes as PGE.sub.2 and PGF.sub.2.sub..alpha..

Abstract: Novel methods are disclosed for transforming PGA.sub.2 and 15.beta.-PGA.sub.2 and their acetates, methyl esters, and acetate methyl esters to various prostanoic acids and esters of the PGE.sub.2 and PGF.sub.2.sub..alpha. series. Some of the latter are novel and are useful for the same pharmacological purposes as PGE.sub.2 and PGF.sub.2.sub..alpha..