Abstract: Disclosed is a method and a family of materials useful for removing immune complexes from blood preferentially to soluble antibodies. The material comprises analogs of proteins which bind to the Fc region of immunoglobulin. The analogs are produced by truncating or otherwise altering the amino acid sequence of the binding protein to reduce their affinity for Fc. An array of such analogs disposed about the surface of an insoluble matrix has the ability to form multiple points of attachment to the multiple Fc's in a complex so as to bind complex strongly, whereas only weak associations are developed between the Fc region of soluble IgG and inidivdual analogs. The preferred analogs are truncated proteins homologous to a portion of the domains of Protein A or Protein G which bind with Fc. Complex may be removed from whole blood or serum using the material and conventional plasmapheresis techniques.

Abstract: A laminate is formed by needling a layer of hydrophobic fibers through a middle odor-absorbing layer into a bottom layer of closed-cell foamed thermoplastic. The laminate may be thermoformed to produce articles having a surface shape conforming to the contours of a region of the human body such as resilient supportive innersoles, soft casts or splints, and impact-absorbing pads. Such articles, in addition to their usual function, absorb odors significantly and wick perspiration away from the skin. Innersoles made from the laminates resist delamination and disintegration even when used in athletic footwear.