Patents Represented by Attorney Edward A. Conroy

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  • 4,8-disubstituted-1,2-dihydro and 1,2,3,4-tetrahydroimidazo-[1,5-a] pyrimidines
    Patent number: 4888345
    Abstract: This disclosure describes novel 4,8-disubstituted-1,2-dihydro- and -1,2,3,4-tetrahydro -imidazo-[1,5-a] pyrimidines useful as antihypertensive agents and/or as anxiolytic agents in mammals and as intermediates for the synthesis of biologically active compounds.
    Type: Grant
    Filed: February 24, 1988
    Date of Patent: December 19, 1989
    Assignee: American Cyanamid Company
    Inventors: Shin S. Tseng, John P. Dusza, Joseph W. Epstein
  • Stable ophthalmic preparations containing acetazolamide
    Patent number: 4888168
    Abstract: There is provided a stable, ophthalmic aqueous composition for topical administration, comprising (a) acetazolamide and either (b) a pre-formed, pharmaceutically acceptable, aqueous gel or (c) an aqueous gel-forming liquid capable of forming a pharmaceutically acceptable gel in situ when applied topically to a patient; said composition having a pH of less than 5.0.
    Type: Grant
    Filed: December 2, 1987
    Date of Patent: December 19, 1989
    Assignee: American Cyanamid Company
    Inventors: Angela C. Potts, Mark Gibson
  • Novel 1,4-bis(substituted-amino(-5,8-dihydroxyanthraquinones and leuco bases thereof
    Patent number: 4888137
    Abstract: This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.
    Type: Grant
    Filed: April 27, 1987
    Date of Patent: December 19, 1989
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
    Patent number: 4876252
    Abstract: This disclosure describes novel 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines having antiasthmatic activity.
    Type: Grant
    Filed: May 17, 1988
    Date of Patent: October 24, 1989
    Assignee: American Cyanamid Company
    Inventors: Lawrence W. Torley, Bernard D. Johnson, John P. Dusza
  • 2-Phenyl-4-quinoline carboxylic acids
    Patent number: 4847381
    Abstract: Substituted 4-quinoline-carboxylic acids useful in the treatment of arthritis and inhibition of progressive joint deterioration are disclosed together with methods of use and synthesis thereof.
    Type: Grant
    Filed: August 31, 1987
    Date of Patent: July 11, 1989
    Assignee: American Cyanamid Company
    Inventors: Leslie H. Sutherland, Adolph E. Sloboda, Ralph G. Child, John F. Poletto, Dennis W. Powell
  • Process for preparing 2-chloro-4,5-difluorobenzoic acid
    Patent number: 4833270
    Abstract: This disclosure describes a novel process for preparing 2-chloro-4,5-difluorobenzoic acid which is useful in the preparation of 7-(substituted)piperazinyl-1-substituted-6-fluoro-1,4-dihydro-4-oxo-3-quin oli necarboxylic acid antibacterial agents.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: May 23, 1989
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Yang-I Lin
  • Substituted piperazine-1,4-naphthalenediones useful as anti-asthmatic agents
    Patent number: 4829089
    Abstract: This disclosure describes certain substituted piperazine-1,4-naphthalenediones useful as anti-asthmatic agents.
    Type: Grant
    Filed: July 22, 1988
    Date of Patent: May 9, 1989
    Assignee: American Cyanamid Company
    Inventors: Jeffrey B. Medwid, Lawrence W. Torley, Andrew S. Tomcufcik
  • 1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
    Patent number: 4820738
    Abstract: This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.
    Type: Grant
    Filed: January 28, 1986
    Date of Patent: April 11, 1989
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • Method of treating diabetes with 5-[1-hydroxy-2-(isopropylamino)ethyl]anthranilonitrile
    Patent number: 4814350
    Abstract: This disclosure describes pharmaceutical compositions of matter containing 5-[1-hydroxy-2-(isopropylamino)ethyl]anthranilonitrile and the method of treating diabetes therewith.
    Type: Grant
    Filed: September 10, 1986
    Date of Patent: March 21, 1989
    Assignee: American Cyanamid Company
    Inventors: Jo A. Goidl, Thomas H. Claus
  • Substituted benzimidazoles and benzothidiazoles having anti-asthmatic and/or anti-inflammatory activities
    Patent number: 4808586
    Abstract: This disclosure describes novel substituted 2-phenyl-1H-benzimidazoles and 2-phenyl-1H-benzimidazole-4,7-diones and novel 5-chloro-6-(4-substituted-1-piperazinyl)-2,1,3-benzothiadiazole-4,7-diones ; all of which are highly active as anti-asthmatic and anti-allergic agents.
    Type: Grant
    Filed: November 23, 1987
    Date of Patent: February 28, 1989
    Assignee: American Cyanamid Company
    Inventors: Jeffrey B. Medwid, Lawrence W. Torley
  • Synthesis of cisplatin analogs
    Patent number: 4808730
    Abstract: This disclosure sets forth a novel process for producing cisplatin analogs which possess antitumor activity.
    Type: Grant
    Filed: June 23, 1987
    Date of Patent: February 28, 1989
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • Novel monocycle .beta.-lactam antibacterials
    Patent number: 4808579
    Abstract: The disclosure describes (S)-3-[2-(2-amino-4-thiazolyl)]-(Z)-2-methoxyiminoacetylamino-2-oxo-1-azet idinyliminoacetic acid and (S)-3-[2-(2-amino-4-thiazolyl)]-(Z)-2-methoxyiminoacetylamino-2-(S)-methyl -4-oxo-1-azetidinyliminoacetic acid and the cationic salts thereof which possess antibacterial activity.
    Type: Grant
    Filed: November 13, 1987
    Date of Patent: February 28, 1989
    Assignee: American Cyanamid Company
    Inventors: William V. Curran, Robert H. Lenhard
  • 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
    Patent number: 4788195
    Abstract: This disclosure describes novel 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines having anti-asthmatic activity.
    Type: Grant
    Filed: November 6, 1986
    Date of Patent: November 29, 1988
    Assignee: American Cyanamid Company
    Inventors: Lawrence W. Torley, Bernard D. Johnson, John P. Dusza
  • Substituted piperazine-1,4-naphthalenediones useful for treating asthma, allergic diseases and/or inflammation
    Patent number: 4771061
    Abstract: This disclosure describes certain substituted piperazine-1,4-naphthalenediones useful as anti-asthmatic agents.
    Type: Grant
    Filed: May 6, 1987
    Date of Patent: September 13, 1988
    Assignee: American Cyanamid Company
    Inventors: Jeffrey B. Medwid, Lawrence W. Torley, Andrew S. Tomcufcik
  • Antitumor amino acid and peptide derivatives of 1,4-bis(aminoalkyl and hydroxy-aminoalkyl)amino)-5,8-dihydroxyanthraquinones
    Patent number: 4732970
    Abstract: Antitumor amino acid and peptide derivatives of 1,4-bis[(aminoalkyl and hydroxyaminoalkyl)amino]-5,8-dihydroxyanthraquinones.
    Type: Grant
    Filed: June 13, 1986
    Date of Patent: March 22, 1988
    Assignee: American Cyanamid Company
    Inventors: Thomas L. Fields, Keith C. Murdock, Martin L. Sassiver, Janis Upeslacis
  • .alpha.-[5-methyl-2-(pyridinyl)-1H-imidazol-4-yl]substituted-1-p iperazineethanols useful for treating hypertension
    Patent number: 4732895
    Abstract: This disclosure describes novel substituted .alpha.-[5-methyl-2-pyridyl-1H-imidazol-4-yl]-1-piperazineethanols which possess hypotensive activity.
    Type: Grant
    Filed: May 2, 1986
    Date of Patent: March 22, 1988
    Assignee: American Cyanamid Company
    Inventors: Corris M. Hofmann, Howard Newman, Andrew S. Tomcufcik
  • Process for preparing certain 1,4-di[.omega.-(2-hydroxyethylamino)alkylamino]anthraquinone free bases
    Patent number: 4715993
    Abstract: This disclosure describes a novel process for liberating the free bases of certain 1,4-di[.omega.-(2-hydroxyethylamino)alkylamino]anthraquinones from the salts thereof.
    Type: Grant
    Filed: June 14, 1985
    Date of Patent: December 29, 1987
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Richard L. Webb
  • Heterocyclic-1,2-diamine platinum complexes
    Patent number: 4716157
    Abstract: This disclosure describes platinum complexes of heterocyclic-1,2-diamines which possess the property of inhibiting the growth of tumors in mammals.
    Type: Grant
    Filed: March 20, 1986
    Date of Patent: December 29, 1987
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Ralph G. Child, Joseph J. Hlavka, Yang-I Lin
  • Platinum complexes of diamino-dideoxy sugars and di- or tricarboxylic acids
    Patent number: 4703115
    Abstract: Platinum complexes and Di- or Tricarboxylic acids which is then reacted with the appropriate di- or tricarboxylic acid in aqueous medium.
    Type: Grant
    Filed: December 17, 1984
    Date of Patent: October 27, 1987
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Ralph G. Child, Panayota Bitha, Yang-i Lin
  • Method for treating hypertension using 3-(4-imidazolylmethylene)-carbazic and dithiocarbazic acid esters
    Patent number: 4696940
    Abstract: This disclosure describes compositions of matter containing substituted 3-(4-imidazolymethlene)carbazic and dithiocarbazic acid esters and the method of treating hypertension therewith.
    Type: Grant
    Filed: October 29, 1986
    Date of Patent: September 29, 1987
    Assignee: American Cyanamid Company
    Inventor: Peter S. Chan