Patents Represented by Attorney Edward A. Conroy

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  • Novel 1,4-bis(substituted-amino(-5,8-dihydroxyanthraquinones and leuco bases thereof
    Patent number: 4888137
    Abstract: This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.
    Type: Grant
    Filed: April 27, 1987
    Date of Patent: December 19, 1989
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • Stable ophthalmic preparations containing acetazolamide
    Patent number: 4888168
    Abstract: There is provided a stable, ophthalmic aqueous composition for topical administration, comprising (a) acetazolamide and either (b) a pre-formed, pharmaceutically acceptable, aqueous gel or (c) an aqueous gel-forming liquid capable of forming a pharmaceutically acceptable gel in situ when applied topically to a patient; said composition having a pH of less than 5.0.
    Type: Grant
    Filed: December 2, 1987
    Date of Patent: December 19, 1989
    Assignee: American Cyanamid Company
    Inventors: Angela C. Potts, Mark Gibson
  • 4,8-disubstituted-1,2-dihydro and 1,2,3,4-tetrahydroimidazo-[1,5-a] pyrimidines
    Patent number: 4888345
    Abstract: This disclosure describes novel 4,8-disubstituted-1,2-dihydro- and -1,2,3,4-tetrahydro -imidazo-[1,5-a] pyrimidines useful as antihypertensive agents and/or as anxiolytic agents in mammals and as intermediates for the synthesis of biologically active compounds.
    Type: Grant
    Filed: February 24, 1988
    Date of Patent: December 19, 1989
    Assignee: American Cyanamid Company
    Inventors: Shin S. Tseng, John P. Dusza, Joseph W. Epstein
  • 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
    Patent number: 4876252
    Abstract: This disclosure describes novel 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines having antiasthmatic activity.
    Type: Grant
    Filed: May 17, 1988
    Date of Patent: October 24, 1989
    Assignee: American Cyanamid Company
    Inventors: Lawrence W. Torley, Bernard D. Johnson, John P. Dusza
  • 2-Phenyl-4-quinoline carboxylic acids
    Patent number: 4847381
    Abstract: Substituted 4-quinoline-carboxylic acids useful in the treatment of arthritis and inhibition of progressive joint deterioration are disclosed together with methods of use and synthesis thereof.
    Type: Grant
    Filed: August 31, 1987
    Date of Patent: July 11, 1989
    Assignee: American Cyanamid Company
    Inventors: Leslie H. Sutherland, Adolph E. Sloboda, Ralph G. Child, John F. Poletto, Dennis W. Powell
  • Process for preparing 2-chloro-4,5-difluorobenzoic acid
    Patent number: 4833270
    Abstract: This disclosure describes a novel process for preparing 2-chloro-4,5-difluorobenzoic acid which is useful in the preparation of 7-(substituted)piperazinyl-1-substituted-6-fluoro-1,4-dihydro-4-oxo-3-quin oli necarboxylic acid antibacterial agents.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: May 23, 1989
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Yang-I Lin
  • Substituted piperazine-1,4-naphthalenediones useful as anti-asthmatic agents
    Patent number: 4829089
    Abstract: This disclosure describes certain substituted piperazine-1,4-naphthalenediones useful as anti-asthmatic agents.
    Type: Grant
    Filed: July 22, 1988
    Date of Patent: May 9, 1989
    Assignee: American Cyanamid Company
    Inventors: Jeffrey B. Medwid, Lawrence W. Torley, Andrew S. Tomcufcik
  • 1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
    Patent number: 4820738
    Abstract: This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.
    Type: Grant
    Filed: January 28, 1986
    Date of Patent: April 11, 1989
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • Method of treating diabetes with 5-[1-hydroxy-2-(isopropylamino)ethyl]anthranilonitrile
    Patent number: 4814350
    Abstract: This disclosure describes pharmaceutical compositions of matter containing 5-[1-hydroxy-2-(isopropylamino)ethyl]anthranilonitrile and the method of treating diabetes therewith.
    Type: Grant
    Filed: September 10, 1986
    Date of Patent: March 21, 1989
    Assignee: American Cyanamid Company
    Inventors: Jo A. Goidl, Thomas H. Claus
  • Novel monocycle .beta.-lactam antibacterials
    Patent number: 4808579
    Abstract: The disclosure describes (S)-3-[2-(2-amino-4-thiazolyl)]-(Z)-2-methoxyiminoacetylamino-2-oxo-1-azet idinyliminoacetic acid and (S)-3-[2-(2-amino-4-thiazolyl)]-(Z)-2-methoxyiminoacetylamino-2-(S)-methyl -4-oxo-1-azetidinyliminoacetic acid and the cationic salts thereof which possess antibacterial activity.
    Type: Grant
    Filed: November 13, 1987
    Date of Patent: February 28, 1989
    Assignee: American Cyanamid Company
    Inventors: William V. Curran, Robert H. Lenhard
  • Substituted benzimidazoles and benzothidiazoles having anti-asthmatic and/or anti-inflammatory activities
    Patent number: 4808586
    Abstract: This disclosure describes novel substituted 2-phenyl-1H-benzimidazoles and 2-phenyl-1H-benzimidazole-4,7-diones and novel 5-chloro-6-(4-substituted-1-piperazinyl)-2,1,3-benzothiadiazole-4,7-diones ; all of which are highly active as anti-asthmatic and anti-allergic agents.
    Type: Grant
    Filed: November 23, 1987
    Date of Patent: February 28, 1989
    Assignee: American Cyanamid Company
    Inventors: Jeffrey B. Medwid, Lawrence W. Torley
  • Synthesis of cisplatin analogs
    Patent number: 4808730
    Abstract: This disclosure sets forth a novel process for producing cisplatin analogs which possess antitumor activity.
    Type: Grant
    Filed: June 23, 1987
    Date of Patent: February 28, 1989
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
    Patent number: 4788195
    Abstract: This disclosure describes novel 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines having anti-asthmatic activity.
    Type: Grant
    Filed: November 6, 1986
    Date of Patent: November 29, 1988
    Assignee: American Cyanamid Company
    Inventors: Lawrence W. Torley, Bernard D. Johnson, John P. Dusza
  • Substituted piperazine-1,4-naphthalenediones useful for treating asthma, allergic diseases and/or inflammation
    Patent number: 4771061
    Abstract: This disclosure describes certain substituted piperazine-1,4-naphthalenediones useful as anti-asthmatic agents.
    Type: Grant
    Filed: May 6, 1987
    Date of Patent: September 13, 1988
    Assignee: American Cyanamid Company
    Inventors: Jeffrey B. Medwid, Lawrence W. Torley, Andrew S. Tomcufcik
  • .alpha.-[5-methyl-2-(pyridinyl)-1H-imidazol-4-yl]substituted-1-p iperazineethanols useful for treating hypertension
    Patent number: 4732895
    Abstract: This disclosure describes novel substituted .alpha.-[5-methyl-2-pyridyl-1H-imidazol-4-yl]-1-piperazineethanols which possess hypotensive activity.
    Type: Grant
    Filed: May 2, 1986
    Date of Patent: March 22, 1988
    Assignee: American Cyanamid Company
    Inventors: Corris M. Hofmann, Howard Newman, Andrew S. Tomcufcik
  • Antitumor amino acid and peptide derivatives of 1,4-bis(aminoalkyl and hydroxy-aminoalkyl)amino)-5,8-dihydroxyanthraquinones
    Patent number: 4732970
    Abstract: Antitumor amino acid and peptide derivatives of 1,4-bis[(aminoalkyl and hydroxyaminoalkyl)amino]-5,8-dihydroxyanthraquinones.
    Type: Grant
    Filed: June 13, 1986
    Date of Patent: March 22, 1988
    Assignee: American Cyanamid Company
    Inventors: Thomas L. Fields, Keith C. Murdock, Martin L. Sassiver, Janis Upeslacis
  • Process for preparing certain 1,4-di[.omega.-(2-hydroxyethylamino)alkylamino]anthraquinone free bases
    Patent number: 4715993
    Abstract: This disclosure describes a novel process for liberating the free bases of certain 1,4-di[.omega.-(2-hydroxyethylamino)alkylamino]anthraquinones from the salts thereof.
    Type: Grant
    Filed: June 14, 1985
    Date of Patent: December 29, 1987
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Richard L. Webb
  • Heterocyclic-1,2-diamine platinum complexes
    Patent number: 4716157
    Abstract: This disclosure describes platinum complexes of heterocyclic-1,2-diamines which possess the property of inhibiting the growth of tumors in mammals.
    Type: Grant
    Filed: March 20, 1986
    Date of Patent: December 29, 1987
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Ralph G. Child, Joseph J. Hlavka, Yang-I Lin
  • Platinum complexes of diamino-dideoxy sugars and di- or tricarboxylic acids
    Patent number: 4703115
    Abstract: Platinum complexes and Di- or Tricarboxylic acids which is then reacted with the appropriate di- or tricarboxylic acid in aqueous medium.
    Type: Grant
    Filed: December 17, 1984
    Date of Patent: October 27, 1987
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Ralph G. Child, Panayota Bitha, Yang-i Lin
  • Method of treating transplanted tumors and modulating the immune response
    Patent number: 4696935
    Abstract: This disclosure describes compositions of matter useful for inducing the regression of transplanted tumors in warm-blooded animals and for enhancing the immune system, and the method of treatment of transplanted tumors and enhancing the immune response in mammals therewith, the active ingredients of said compositions of matter being 3,6-bis[2-(1-piperidino)ethoxy]acridine or the pharmacologically acceptable acid-addition salts thereof.
    Type: Grant
    Filed: October 27, 1981
    Date of Patent: September 29, 1987
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Martin R. Damiani, Frederick E. Durr