Patents Represented by Attorney, Agent or Law Firm Edward H. Berkowitz
  • Patent number: 7800369
    Abstract: Remote adjustment of a selected one of a plurality of adjustable NMR probe circuit components is achieved with a plurality of selectable linear actuators, the selected one of which urges a platen against a respective driven gear, azimuthally locked to its shaft, to displace it axially along that shaft. When the driven gear engages a driving gear a single driving motor is energized and controlled to effect the desired adjustment.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: September 21, 2010
    Assignee: Varian, Inc.
    Inventors: Xiao Zhang, John S. Tobias
  • Patent number: 7701219
    Abstract: NMR (Nuclear Magnetic Resonance) capacitor switches allow for adjusting the resonant frequency ranges of NMR measurement circuits by inserting or removing capacitors having different values into the circuits. A change of position of a single switching member is used to change the contact state of at least two capacitors. In some embodiments, at least two pairs of external contacts are disposed at distinct longitudinal levels along a channel, and a slider including multiple longitudinally-spaced capacitors is moved longitudinally within the channel to establish electrical contact between the external contact pairs and different capacitors along the slider. In other embodiments, two capacitor columns are disposed along the channel, and a movable longitudinal member establishes electrical contact between the two columns at different longitudinal levels along the columns. In some embodiments, capacitor covers or intracapacitor blocks are provided to protect the capacitors.
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: April 20, 2010
    Assignee: Varian, Inc.
    Inventors: James Finnigan, Joseph Murphy
  • Patent number: 7352185
    Abstract: A single RF port, multiply-resonant circuit comprises coupled resonant sub-circuits coupled through an adjustable reactive element exhibiting a dynamic range that includes a value of the reactive component of sufficient magnitude to produce an impedance producing substantial mutual isolation of the sub-circuits.
    Type: Grant
    Filed: November 22, 2006
    Date of Patent: April 1, 2008
    Assignee: Varian, Inc.
    Inventors: Albert P. Zens, James P. Finnigan
  • Patent number: 7106063
    Abstract: An NMR resonant structure is formed of axial conductors (54a, 54b, 54c, and 54d) and end members (50,51), supporting said conductors to form a coil structure (8) of desired electrical topology wherein the end members combine the function of RF interconnects between selected axial conductors (inductors) with an axial constraint on RF field prevailing outside the axial bounds of the end members, and if so desired, comprise a selected capacitance 61 for the resonant structure.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: September 12, 2006
    Assignee: Varian, Inc.
    Inventors: Albert P. Zens, Peter Nakatani
  • Patent number: 7088102
    Abstract: A time multiplex arrangement for presenting multiple samples to a single channel of NMR excitation/data acquisition includes means for rapid exchange of physical position between plural samples or sample portions from the measurement volume of the NMR instrument while said samples remain in a substantially the same homogeneous magnetic field. While a delay is imposed upon time evolution or relaxation of an NMR excited sample outside the sensitive volume of an RF resonator, another sample is actively excited within said RF resonator whereby the steps of NMR measurement are overlapped between at least two samples.
    Type: Grant
    Filed: March 3, 2005
    Date of Patent: August 8, 2006
    Assignee: Varian, Inc.
    Inventor: Albert P. Zens
  • Patent number: 6812703
    Abstract: An NMR probe comprises a resonator formed of two separate conducting loops disposed on opposite sides of the sample, where one loop is driven and the other floats in a preferred operating mode. Slotted shields are disposed coaxially within said loops and outside the sample with slots aligned with gaps between the loops.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: November 2, 2004
    Assignee: Varian, Inc.
    Inventors: Thomas de Swiet, Knut G. Mehr
  • Patent number: 6813019
    Abstract: A method and apparatus for the spectrochemical analysis of a sample in which a solid state array detector (82) is used to detect radiation (62) of spectrochemical interest. The invention involves the use of a shutter (72) adjacent the entrance aperture (70) of a polychromator (74-80) to expose the detector (82) to the radiation (62) for varying lengths of time whereby for short duration exposure times charge accumulation in elements (i.e. pixels) of the detector (82) due to high intensity components of the radiation is limited and for longer exposure times charge accumulation in elements (pixels) of the detector (82) due to feeble intesity components of radiation (62) is increased. This ensures that each reading of the detector (82) includes at least one exposure in which the amount of charge accumulated at each wavelength of interest is neither too little or too great.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: November 2, 2004
    Assignee: Varian Australia PTY LTD
    Inventors: Michael R. Hammer, Philip V. Wilson, Mark R. Williams, Dower C. Bricker, Martin K. Masters, Stewart R. Campbell, Peter G. Layton
  • Patent number: 6806713
    Abstract: A multimode RF probe for use with a sample oriented at an angle &thgr; to a polarizing field B0 produces a resultant RF magnetic field exhibiting enhanced coupling to the sample. The multiple modes are furnished by a quadrature coil, or a solenoidal coil in combination with either a saddle coil or quadrature coil.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: October 19, 2004
    Assignee: Varian, Inc.
    Inventor: Wai Ha Wong
  • Patent number: 6795181
    Abstract: A spectrometry instrument with exchangeable accessories (34, 48, 50, 52) providing, for example, different sample presentation facilities. The accessories include a manually operable cam-lock facility (54, 68) for quick and easy attachment of an accessory to the instrument. The instrument also includes an electrical circuit (86-90), which is completed by a circuit portion (100) in an accessory when the accessory is attached to the instrument, for generating a unique identifying voltage (94) to thereby identify that accessory. This allows for automatic loading in a controlling computer of programs for setting up and running the instrument for measurement regimes using that accessory.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: September 21, 2004
    Assignee: Varian Australia PTY LTD
    Inventors: Vanessa Mary Joy McCallum, Martin Kaselis, Hans Heinrich Egli
  • Patent number: 6768305
    Abstract: A queue of samples for NMR analysis is disposed within a thermally isolate NMR magnet bore and distal elements of the queue approach thermal equilibrium concurrently with NMR analysis of a sample within the sensitive volume. In one embodiment, a sequence of NMR sample cells within a barrel coaxial with a vertical bore NMR spectrometer are maintained at a selected temperature by a heated gas and the queue of sample cells advances to the analytic position under gravity when the lowest sample cell is displaced from the queue in response to an end-of-analysis signal generated by said spectrometer.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: July 27, 2004
    Assignee: Varian, Inc.
    Inventor: Paul A. Keifer
  • Patent number: 6765381
    Abstract: An extended Maxwell pair has a pair of cylindrical gradient coils disposed coaxially, carrying equal currents in mutually opposite directions. Each of these gradient coils may be surrounded by a coaxially disposed cylindrically extended shield coil so as to cancel the magnetic field outside. For given values of radii of the gradient and shield coils, the length and the center-to-center separation of the pair of gradient coils are determined by numerically solving an equation which is derived from the condition that the currents through the gradient and shield coils should together generate a magnetic field inside with a linear gradient. The equation to be solved is derived by calculating the magnetic field by a Fourier-Bessel expansion method incorporating the condition that the shield coils do shield the magnetic field inside and cancel the field outside the system.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: July 20, 2004
    Assignee: Varian, Inc.
    Inventor: Thomas M. Barbara
  • Patent number: 6753959
    Abstract: Spectroscopy apparatus for spectrochemical analysis of a sample having an excitation source (60) for providing spectral light (62) of the sample for analysis. The spectral light (62) is analysed via an optical system (64-66-68) that includes a polychromator (70, 74-80) and solid state multielement array detector (82). The elements (i.e. pixels) of the detector (82) are serially reel by means (84) to provide light intensity measurements as a function of wavelength. A problem is that the elements (pixels) of the detector (82) continue to accumulate change during the serial read-out. This is avoided by providing an optical shutter (72) for blocking the spectral light (62) whilst elements (pixels) of the detector (82) are being serially read. Shutter (72) has a piezoelectric actuator which is preferably a bimorph mounted as a cantilever. It is preferably located adjacent to the entrance aperture (70) of the polychromator.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: June 22, 2004
    Assignee: Varian Australia Pty LTD
    Inventors: Michael R. Hammer, Martin K. Masters, Stewart R. Campbell, Peter G. Layton
  • Patent number: 6710336
    Abstract: In a quadrupole ion trap mass spectrometer, a library of optimized notched waveforms are pre-calculated, optimized and stored in a fast memory such as semiconductor RAM. Computer controlled apparatus selectively applies the pre-calculated waveforms to end caps of the quadrupole ion trap for isolating an ion with a specific mass to charge ratio. The pre-calculated waveforms are optimized notch waveforms with each waveform being pre-calculated for a specific mass. The memory further stores a library of single frequency CID waveforms for use in collision induced dissociation of an isolated ion. By providing the pre-calculated waveforms, a method is provided to isolate and dissociate a selected ion.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: March 23, 2004
    Assignee: Varian, Inc.
    Inventor: Gregory J. Wells
  • Patent number: 6667674
    Abstract: A birdcage resonator has a pair of conductor rings separated from each other along a central axis and a plural number of axially disposed conductor rungs, which extend between the rings and are evenly spaced around the central axis. Each of the rungs has a sectional shape with thickness or a radial extension comparable to or greater than its width or its azimuthal extension. Measures of the width and thickness of the rungs may be determined by using them as parameters to calculate the values of Q factor from an analytical procedure to locate parameter value ranges corresponding to maximal Q. Geometric calculations for filling factor yield ranges of parameters providing for compromise parameter values. Saddle coils have been found to exhibit similar enhancement of Q with radially oriented conductor cross section.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: December 23, 2003
    Assignee: Varian, Inc.
    Inventors: Thomas de Swiet, Wai Ha Wong, Marco Romo, James Finnigan, Sean Burns
  • Patent number: 6657720
    Abstract: A spectrometry instrument, e.g., for time-resolved spectroscopy, has quick-change exchangeable accessories (48, 50, 52) which are manually attached via rotation of a camming means to engage and lock a stud member. A circuit element in each accessory (48, 50, 52), such as a resistor or a configured pin connection, acts to generate a voltage in the instrument that uniquely identifies which accessory is attached. A method for measuring a phosphorescence decay characteristic includes applying an excitation pulse to a sample (34); obtaining emission intensity data for a sequence of time delays following the excitation pulse; repeating for at least one further excitation pulse using a different sequence of time delays; and interleaving the data from different excitation pulses to construct a decay characteristic.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: December 2, 2003
    Assignee: Varian Australian Pty LTD
    Inventor: Martin Kaselis
  • Patent number: 6617578
    Abstract: A self-aligned ion guide assembly comprises a plurality of 2N rods radially contained by at least one insulating collar having two grooves axially displaced on the outer periphery of the collar. A wire in each groove electrically contacts and mechanically bonds to alternate rods through respective radially directed holes. Alternatively, the collar is cast about the assembly of rods and wires.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: September 9, 2003
    Assignee: Varian, Inc.
    Inventor: Roger C. Tong
  • Patent number: 6614021
    Abstract: A mass spectrometer having an ion reflecting instead of ion transmissive optics system. The spectrometer includes an ion source (16) for providing a beam of sample particles including ions along an axis (24). Its ion optics system (34-46) establishes a reflecting electrostatic field for reflecting ions along a path (30) from the particle beam and focussing them at an entrance aperture (26) of a mass analyser (25) and ion detector (27) for spectrometric analysis. The invention allows more efficient separation of ions from neutral particles, gives better signal to noise ratios and allows for a compact “optical” path and thus cheaper instrument to be manufacctured. The reflecting electrostatic field can also be used to filter higher energy ions from lower energy ions. An ion optical system as such is also disclosed.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: September 2, 2003
    Assignee: Varian Australian PTY LTD
    Inventor: Iouri Kalinitchenko
  • Patent number: 6590394
    Abstract: A phase-shifted coil comprises nested concentric spiral portions, the terminals of which are progressively offset. Separately tuned concentric such coils of different dimensions exhibit relatively close intercoil clearance in one dimension and relatively large clearances in the orthogonal dimension provide different flux return characteristics for selective RF coupling.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: July 8, 2003
    Assignee: Varian, Inc.
    Inventors: Wai Ha Wong, I-Jaung Feng
  • Patent number: 6559941
    Abstract: An ultraviolet/visible/infrared spectrophotometer, with a pulsed light source (10), has a monochromator with variable slit width to provide variable spectral resolution. The dynamic range at the detectors (24, 28) is reduced by varying the pulse energy emitted by the light source (10) in accordance with the wavelength and slit width settings (34, 36), and/or by varying the slit height in accordance with the slit width. The ligth source (10) may be a xenon flash lamp.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: May 6, 2003
    Assignee: Varian Australia Pty. Ltd.
    Inventor: Michael Ron Hammer
  • Patent number: 6552544
    Abstract: A detunable coil assembly includes a main coil which resonates at a specified resonance frequency and a switchable detuning coil which, when switched on, becomes inductively coupled to the main coil and serves to detune it from its resonance frequency. The detuning coil and the main coil are electrically insulated from each other. The main coil may be of a multiply tuned kind and it may be detuned from more than one of its specified resonance frequencies at the same time by switching on the detuning coil.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: April 22, 2003
    Assignee: Varian, Inc.
    Inventors: Wai Ha Wong, Alan R. Rath