Patents Represented by Attorney Edward L. Mandell
  • Patent number: 5240995
    Abstract: A two phase adhesive matrix for use in an electrically powered iontophoretic delivery device is provided. The adhesive matrix comprises an adhesive hydrophobic polymer phase and about 15 to 60 wt % on a dry weight basis of a hydrophilic polymer phase distributed through the hydrophobic polymer phase. The hydrophilic phase forms upon hydration an interconnecting network of aqueous pathways for passage of the agent through the adhesive. The adhesive can be used to adhere an electrode assembly of an iontophoretic delivery device to a body surface such as skin or a mucosal membrane. Alternatively, the adhesive can be used to adhere together two or more elements of an iontophoretic delivery device.
    Type: Grant
    Filed: August 6, 1991
    Date of Patent: August 31, 1993
    Assignee: Alza Corporation
    Inventors: J. Richard Gyory, Ronald P. Haak, Felix Theeuwes, Patrick J. Lew
  • Patent number: 5240713
    Abstract: The present invention is directed to a long-term dispensing device for the controlled delivery of a beneficial agent in a hydrophilic carrier, which device quickly and continuously delivers an effective amount of agent followed by a continuous and sustained delivery of agent in a controlled and uniform amount over a prolonged period of time, thus providing for delivery of beneficial agent to an environment of use at two different rates and having a fast startup.
    Type: Grant
    Filed: September 27, 1991
    Date of Patent: August 31, 1993
    Assignee: Alza Corporation
    Inventor: Atul D. Ayer
  • Patent number: 5238687
    Abstract: This invention relates to an active agent delivery device. More particularly, the invention relates to a delivery device that includes a sleeve to protect the delivery device from transient mechanical forces. The delivery device of the invention is robust and resistant to transient mechanical forces. The invention provides a fluid-imbibing delivery device comprising a housing enclosing an internal compartment, said housing having a first wall section that substantially restricts the passage of fluid into the delivery device, i.e. is substantially fluid-impermeable, and that contains a beneficial agent; a second wall section that permits the passage of fluid into the delivery device, i.e. is fluid-permeable, and that contains at least one expandable driving member; and exit means; with a protective sleeve means extending from the first wall section of the housing to cover and protect the second wall section of the housing and the junction of the first and second sections.
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: August 24, 1993
    Assignee: Alza Corporation
    Inventors: Judy A. Magruder, John R. Peery, James B. Eckenhoff
  • Patent number: 5236689
    Abstract: A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
    Type: Grant
    Filed: April 24, 1992
    Date of Patent: August 17, 1993
    Assignee: ALZA Corporation
    Inventors: Patrick S. L. Wong, Felix Theeuwes, James B. Eckenhoff, Steven D. Larsen, Hoa T. Huynh
  • Patent number: 5234424
    Abstract: An improved osmotic engine is disclosed. The osmotic engine is adapted to be used with an osmotically driven syringe which can be used to deliver a beneficial agent, such as a drug, at a pre-determined rate over an extended period of time. The osmotic engine has an exterior wall defining a compartment which contains an osmotic solute. The wall comprises a thin permeable and/or microporous material which is permeable to an external fluid such as water but is impermeable to the solute. The wall also has a delivery orifice drilled therethrough. A rigid non-dissolving ring-shaped wall support is provided for maintaining the shape of the engine during use. The wall support also provides an open fluid flow path extending from the semipermeable wall portion toward the delivery orifice. The open fluid flow path minimizes the time required for the engine to begin pumping.
    Type: Grant
    Filed: June 25, 1991
    Date of Patent: August 10, 1993
    Assignee: Alza Corporation
    Inventors: Su I. Yum, Felix A. Landrau, James Z. Huang
  • Patent number: 5234694
    Abstract: This invention relates to an active agent delivery device. More particularly, the invention relates to a delivery device that includes a sleeve to protect the delivery device from transient mechanical forces. The delivery device of the invention is robust and resistant to transient mechanical forces. The invention provides a fluid-imbibing delivery device comprising a housing enclosing an internal compartment, said housing having a first wall section that substantially restricts the passage of fluid into the delivery device, i.e. is substantially fluid-impermeable, and that contains a beneficial agent; a second wall section that permits the passage of fluid into the delivery device, i.e. is fluid-permeable, and that contains at least one expandable driving member; and exit means; with a protective sleeve means extending from the first wall section of the housing to cover and protect the second wall section of the housing and the junction of the first and second sections.
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: August 10, 1993
    Assignee: ALZA Corporation
    Inventors: Judy A. Magruder, John R. Peery, James B. Eckenhoff
  • Patent number: 5234692
    Abstract: This invention relates to an active agent delivery device. More particularly, the invention relates to a delivery device that includes a sleeve to protect the delivery device from transient mechanical forces. The delivery device of the invention is robust and resistant to transient mechanical forces. The invention provides a fluid-imbibing delivery device comprising a housing enclosing an internal compartment, said housing having a first wall section that substantially restricts the passage of fluid into the delivery device, i.e. is substantially fluid-impermeable, and that contains a beneficial agent; a second wall section that permits the passage of fluid into the delivery device, i.e. is fluid-permeable, and that contains at least one expandable driving member; and exit means: with a protective sleeve means extending from the first wall section of the housing to cover and protect the second wall section of the housing and the junction of the first and second sections.
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: August 10, 1993
    Assignee: Alza Corporation
    Inventors: Judy A. Magruder, John R. Peery, James B. Eckenhoff
  • Patent number: 5234693
    Abstract: This invention relates to an active agent delivery device. More particularly, the invention relates to a delivery device that includes a sleeve to protect the delivery device from transient mechanical forces. The delivery device of the invention is robust and resistant to transient mechanical forces. The invention provides a fluid-imbibing delivery device comprising a housing enclosing an internal compartment, said housing having a first wall section that substantially restricts the passage of fluid into the delivery device, i.e. is substantially fluidimpermeable, and that contains a beneficial agent; a second wall section that permits the passage of fluid into the delivery device, i.e. is fluid-permeable, and that contains at least one expandable driving member; and exit means; with a protective sleeve means extending from the first wall section of the housing to cover and protect the second wall section of the housing and the junction of the first and second sections.
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: August 10, 1993
    Assignee: Alza Corporation
    Inventors: Judy A. Magruder, John R. Peery, James B. Eckenhoff
  • Patent number: 5234992
    Abstract: An adhesive composition suitable for use as an in-line contact adhesive for electrotransport drug delivery systems.
    Type: Grant
    Filed: February 9, 1989
    Date of Patent: August 10, 1993
    Assignee: ALZA Corporation
    Inventors: J. Richard Gyory, Ronald P. Haak, Felix Theeuwes, Patrick J. Lew
  • Patent number: 5232438
    Abstract: A membrane capable of inhibiting agent release from a delivery system when no electrical current is flowing and yet provide minimal impedance to electrically-assisted agent delivery, useful both for incorporating into electrotransport agent delivery systems and for use in measuring agent release rates in in vitro testing.
    Type: Grant
    Filed: June 15, 1992
    Date of Patent: August 3, 1993
    Assignee: Alza Corporation
    Inventors: Felix Theeuwes, J. Richard Gyory, Ronald P. Haak
  • Patent number: 5232705
    Abstract: A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: August 3, 1993
    Assignee: Alza Corporation
    Inventors: Patrick S. Wong, Felix Theeuwes, Atul D. Ayer, Anthony L. Kuczynski
  • Patent number: 5221536
    Abstract: A dosage form is disclosed comprising an anti-Parkinson's disease drug for administering to a patient in need of anti-Parkinson's disease therapy.
    Type: Grant
    Filed: June 17, 1991
    Date of Patent: June 22, 1993
    Assignee: Alza Corporation
    Inventors: David E. Edgren, Howard A. Carpenter, Gurdish K. Bhatti, Atul D. Ayer
  • Patent number: 5215753
    Abstract: A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a semipermeable housing defining a internal space, (2) an optional and presently preferred in the space, (3) a heat responsive composition comprising a beneficial agent in the space, (4) a space consuming member in the device, (5) a non-toxic compound blended with the heat responsive composition for enhancing its viscosity; (6) an exit port in the wall for increasing the internal pressure of the dispenser and for simultaneously letting the beneficial agent exit through said port from the device, and (7) an embodiment comprising a prehydrating fluid for fastening the start-up of delivery from the delivery system.
    Type: Grant
    Filed: March 12, 1992
    Date of Patent: June 1, 1993
    Assignee: ALZA Corporation
    Inventors: Jeremy C. Wright, James B. Eckenhoff, Frederick H. Maruyama, John R. Peery
  • Patent number: 5213809
    Abstract: A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a semipermeable housing defining a internal space, (2) an optional and presently preferred in the space, (3) a heat responsive composition comprising a beneficial agent in the space, (4) a space consuming member in the device, (5) a non-toxic compound blended with the heat responsive composition for enhancing its viscosity; (6) an exit port in the wall for increasing the internal pressure of the dispenser and for simultaneously letting the beneficial agent exit through said port from the device, and (7) an embodiment comprising a prehydrating fluid for fastening the start-up of delivery from the delivery system.
    Type: Grant
    Filed: March 12, 1992
    Date of Patent: May 25, 1993
    Assignee: ALZA Corporation
    Inventors: Jeremy C. Wright, James B. Eckenhoff, Frederick H. Maruyama, John R. Peery
  • Patent number: 5203768
    Abstract: A transdermal drug delivery device (20) is provided having both an active drug reservoir (24) and a passive drug reservoir (26). Drug is actively delivered by iontophoresis from the active drug reservoir (24) by an electric field generated by a power source (21). Simultaneously, drug is delivered from passive reservoir (26) by passive (i.e., non-electrically assisted) diffusion. In one embodiment, the passive drug reservoir (26) is electrically insulated from the active drug reservoir (24). In a second embodiment, both the active and the passive drug are contained in the same reservoir (34). In the second embodiment, the active drug is ionizable while the passive drug is non-ionizable. Most preferably, the active drug is an ionizable form (i.e., a salt form) of the passive drug.
    Type: Grant
    Filed: July 24, 1991
    Date of Patent: April 20, 1993
    Assignee: ALZA Corporation
    Inventors: Ronald P. Haak, Felix Theeuwes, J. Richard Gyory
  • Patent number: 5204116
    Abstract: A dosage form is disclosed comprising a first layer and a second layer. The first layer provides immediate therapy and comprises a drug stereoisomer and the second layer provides prolonged therapy and comprises a drug racemate.
    Type: Grant
    Filed: May 1, 1991
    Date of Patent: April 20, 1993
    Assignee: Alza Corporation
    Inventors: David E. Edgren, Gurdish K. Bhatti, Judy A. Magruder
  • Patent number: 5200197
    Abstract: An osmotic device is disclosed comprising an exterior coat comprising an estrogenic and a progestogenic steroid that are delivered immediately as a contraceptive pair for fertility regulation in a female, and a compartment comprising an estrogenic steroid that is delivered at a controlled rate over a prolonged period of time for fertility regulation in a female.
    Type: Grant
    Filed: December 9, 1991
    Date of Patent: April 6, 1993
    Assignee: Alza Corporation
    Inventors: Jeri D. Wright, Jerry D. Childers, Brian L. Barclay, Patrick S.-L. Wong, Linda E. Atkinson
  • Patent number: 5198223
    Abstract: The present invention provides compositions and methods for the transdermal administration of a therapeutically effective amount of a synthetic 19-nor-progesterone (ST-1435) and an estrogen, in combination, together with, optionally, a suitable permeation enhancer.
    Type: Grant
    Filed: March 9, 1992
    Date of Patent: March 30, 1993
    Assignee: Alza Corporation
    Inventors: Robert M. Gale, Diane E. Nedberge, Linda E. Atkinson
  • Patent number: 5198229
    Abstract: The present invention is directed to a fluid-imbibing drug delivery device having a first, low density such that it floats in the stomach contents for a predetermined prolonged period of time, during which prolonged period of time it dispenses a drug or other active agent to the stomach, and having a second, higher density such that the device exits the stomach at the end of the predetermined prolonged period of time.
    Type: Grant
    Filed: June 5, 1991
    Date of Patent: March 30, 1993
    Assignee: ALZA Corporation
    Inventors: Patrick S. L. Wong, Felix Theeuwes, Steven D. Larsen
  • Patent number: RE34365
    Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.
    Type: Grant
    Filed: August 5, 1991
    Date of Patent: August 31, 1993
    Inventor: Felix Theeuwes