Patents Represented by Attorney Edward Lentz

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  • Process for making phenylthiomethylpyridinylalkenoates
    Patent number: 5700943
    Abstract: This invention relates to a process of making a compound of formula I ##STR1## where R.sub.1 contains an .alpha.,.beta.-unsaturated carbonyl group & R.sub.n is hydrogen or nonhydrogen radicals which do not have a functional group which interferes with the coupling reaction, which process comprises coupling a thiolphenol or phenylalkylmercaptan with a chloromethylpyridine in the presence of DBU under an inert atmosphere. These compounds are leukotriene antagonists and as such can be used in treating various diseases associated with leukotrienes.
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: December 23, 1997
    Assignee: SmithKline Beecham Corporation
    Inventor: Robert A. Daines
  • Xanthine derivatives
    Patent number: 5409934
    Type: Grant
    Filed: July 7, 1993
    Date of Patent: April 25, 1995
    Inventors: David G. Smith, Derek R. Buckle, Ashley E. Fenwick
  • Process for asymmetric total synthesis of camptothecin analogues
    Patent number: 5405963
    Abstract: The present invention provides a process for the asymmetric synthesis of camptothecin analogues as well as novel chemical intermediates of Formula I, II, and III. In general, the present process comprises conversion of a cis dioxolanone, having the same desired absolute configuration as the desired camptothecin analogue, to a compound of Formula I, II, or III, which compound is then converted to the desired camptothecin analogue.
    Type: Grant
    Filed: June 10, 1993
    Date of Patent: April 11, 1995
    Assignee: SmithKline Beecham Corporation
    Inventors: Joseph Fortunak, John Kitteringham, Nicholas Sisti, Jeffery Wood