Abstract: The invention is for a vaginal dispenser comprising a wall surrounding an internal lumen and having a pair of ends with one end placed inside the other end to form a closed dispenser. A vaginally administrable beneficial agent is housed in the lumen for release by the dispenser over time.

Abstract: Applications of bioerodible polymers as surgical "leave behind" products in the areas of orthopedic, thoracic, abdominal, ocular and liver/spleen surgery.

Abstract: Rate-controlled transdermal delivery devices are disclosed which utilize an in-line adhesive to maintain the device on the skin and deliver an agent which is a solvent for the in-line adhesive. The initial equilibrated concentration of the agent in the agent reservoir and the adhesive is below saturation and the reservoir comprises the agent dissolved in a solvent with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of the agent in reservoir is sufficient to prevent the activity of the agent in the reservoir from decreasing by more than about 50% and preferrably no more than about 25% during the predetermined period of administration; and the thicknesses of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and, preferrably at least 75% initial equilibrated agent loading is in the reservoir layer.

Abstract: A transdermal delivery device for delivering drugs, typically ionized drugs, from an aqueous reservoir is described. The device comprises an aqueous drug reservoir in the form of a gel confined between an impermeable backing member and a porous support structure. In preferred embodiments the support structure is the substrate to which is applied a porous or patterned in-line adhesive. A strippable release liner is preferably provided on the adhesive while in the package. The devices are usable to deliver drugs such as chlorpheniramine maelate, brompheneiramine maleate and scopolamine hydrobromide.

Abstract: A medical device for the transdermal delivery of an active agent through sensitive intact skin is provided. The device comprises a matrix containing the drug having reinforcing means, preferably in the form of a fabric, embedded in the upper surface of the matrix. The matrix is formed of an agent permeable material which is tacky but does not adhesively bond to the skin. The device is sufficiently flexible and deformable that the combination of tackiness, flexibility, and deformation permits the device to be maintained in agent transmitting relationship upon skin at such sensitive areas as the scrotum, labia, breast, or penis, for example. In certain embodiments, the skin distal surface is provided with a layer of an agent impermeable material to reduce transfer of the agent from the patient to others.