Patents Represented by Attorney Edward P. Gray
-
Patent number: 5874103Abstract: An aqueous base suspension concentrate of an ionophore antibiotic or ionophore antibiotics capable of aqueous dilution (if desired) and capable (with or without such aqueous dilution) of being orally administered to an animal (eg; by drenching), said concentration comprising(I) at least one ionophore antibiotic in (II) an aqueous system containing( ) a wetting and/or surfactant agent(ii) an antifreeze agent or agents in which the ionophore antibiotic or antibiotics is or are no more than sparingly soluble,(iii) a suspension agent,(iv) optionally an antifoam agent or system,(v) optionally a preservative,(vi) optionally a de-bittering agent,(vii) optionally a pH buffering system, and(viii) water.Type: GrantFiled: July 23, 1996Date of Patent: February 23, 1999Assignee: Eli Lilly and CompanyInventors: Derek George Moore, Lionel Barry Lowe, Kevin Charles Palmer, Kim Ewing Melville Agnew
-
Patent number: 5612315Abstract: Parenteral pharmaceutical formulations of human growth hormone, which are stabilized against aggregation, comprising biosynthetic human growth hormone, glycine, and mannitol. Methods of reducing aggregation of human growth hormone in parenteral formulations are also provided.Type: GrantFiled: July 6, 1992Date of Patent: March 18, 1997Assignee: Eli Lilly and CompanyInventors: Michael J. Pikal, Michael L. Roy
-
Patent number: 4902694Abstract: 4-[Thieno[3,2-c]pyridinyl]-pyridinecarboxylic acid esters as calcium channel modulators, methods of use and pharmaceutical compositions therefor.Type: GrantFiled: August 11, 1988Date of Patent: February 20, 1990Assignee: Eli Lilly and CompanyInventors: Donald R. Holland, James H. Wikel
-
Patent number: 4801616Abstract: This invention provides certain diphenylmethane derivatives, their pharmaceutical formulations, and their use in treating inflammation and arthritis in mammals.Type: GrantFiled: March 25, 1986Date of Patent: January 31, 1989Assignee: Eli Lilly and CompanyInventor: D. Mark Gapinski
-
Patent number: 4798834Abstract: A therapeutic method employing 2,3-dihydroergolines is disclosed. Said method enhances serotonergic function in the nervous system of a mammal in need thereof, thereby finding application in serotonin-mediated physiological manifestations including memory, depression, anxiety, pain and appetite. Also disclosed are pharmaceutical compositions containing said 2,3-dihydroergolines in admixture with pharmaceutically acceptable diluents and carriers.Type: GrantFiled: August 31, 1987Date of Patent: January 17, 1989Assignee: Eli Lilly and CompanyInventors: Leander Merritt, John S. Ward
-
Patent number: 4797405Abstract: Pharmaceutical compositions containing pergolide or a salt thereof stabilized to decomposition by light by incorporation therewith of a stabilizing agent selected from polyvinylpyrrolidone, .alpha.-tocopherol succinate and propyl gallate.Type: GrantFiled: October 26, 1987Date of Patent: January 10, 1989Assignee: Eli Lilly and CompanyInventors: James W. Conine, Julian L. Stowers
-
Patent number: 4782152Abstract: The present invention provides a process for decyanating a pergolide intermediate with an alkali metal hydroxide in an alcoholic solvent having a boiling point greater than about 100.degree. C. at a temperature in the range of about 100.degree. C. to about 175.degree. C.Type: GrantFiled: August 16, 1985Date of Patent: November 1, 1988Assignee: Eli Lilly and CompanyInventor: Jerry W. Misner
-
Patent number: 4757005Abstract: A method of increasing the yield of plasminogen activator from a plasminogen activator-producing cell line by adapting said cell line to grow in a suitable growth medium essentially free of fetal calf serum is disclosed. Also disclosed are cell lines capable of producing relatively large quantities of plasminogen activator, and a chemically defined growth medium suitable for adapting a plasminogen activator-secreting cell line to growth in the absence of fetal calf serum.Type: GrantFiled: February 22, 1985Date of Patent: July 12, 1988Assignee: Miles Inc.Inventor: Sham Y. Chan
-
Patent number: 4742080Abstract: A therapeutic method for producing bronchodilation in an individual for whom such therapy is indicated is disclosed. The method comprises administering to said individual an effective bronchodilation amount of certain derivatives of 15-deoxy-16-hydroxy-prostaglandin E.sub.1 esters.Type: GrantFiled: March 15, 1985Date of Patent: May 3, 1988Assignee: Miles Laboratories, Inc.Inventors: Harold C. Kluender, Warren D. Woesner, William G. Biddlecom
-
Patent number: 4734501Abstract: The present invention provides a process for N-alkylating dihydrolysergic acid with a substituted benzenesulfonate derivative.Type: GrantFiled: October 1, 1985Date of Patent: March 29, 1988Assignee: Eli Lilly and CompanyInventor: Gifford P. Marzoni
-
Patent number: 4673638Abstract: A method is provided for detecting a microorganism which produces a desired substance. The method involves overlaying a membrane on an agar surface in a predetermined orientation. Microorganisms are grown on the membrane and the substance allowed to pass into the agar. The membrane is removed and a detectable reaction between the substance and one or more reagents is observed. The location of the microorganism to be detected can be determined by the predetermined orientation, and the microorganism can be isolated by removing it from the membrane. When the substance is not secreted by the microorganism, the microorganisms are lysed releasing the substance for passage into the agar. The microorganisms producing the substance can be located on replicate plates and isolated.Type: GrantFiled: April 9, 1985Date of Patent: June 16, 1987Assignee: Miles Laboratories, Inc.Inventors: Josephine Grosch, Gary A. Wilson, Karen Wollweber, Clifford O. Yehle
-
Patent number: 4673647Abstract: This invention relates to a novel process for the recovery of enzymes obtained from enzyme-producing microorganisms, and to the liquid enzyme product recovered by this process. Typically, the enzyme-containing filtrate from a fermentation of an enzyme-secreting microorganism is concentrated and a precipitation agent such as a salt or an organic solvent is added to the concentrate, thereby forming a cake. Then, a polyol solvent is circulated through the cake to solubilize the enzyme or enzyme complex from the cake and provide a liquid enzyme product. Particularly effective is propylene glycol as the polyol solvent. The liquid enzyme product may be shipped as is or subjected to further treatment to remove the solvent and create an essentially solvent-free enzyme product. The process is especially effective for the recovery of alkaline protease or alpa amylase.Type: GrantFiled: May 6, 1985Date of Patent: June 16, 1987Assignee: Miles Laboratories, Inc.Inventors: Charles E. Brothers, Chong Y. Kim
-
Patent number: 4668822Abstract: A method for preparing an important stereo-specific intermediate in the synthesis of prostaglandin analogs is disclosed. Said intermediate is (+)S-2-hydroxy-2-methyl-hexanoic acid and is prepared via an asymmetric halolactonization reaction utilizing L-proline as the chiral agent.Type: GrantFiled: August 11, 1986Date of Patent: May 26, 1987Assignee: Miles Laboratories, Inc.Inventor: Paul F. Corey
-
Patent number: 4639535Abstract: Disclosed are trisubstituted benzene derivatives of the formula ##STR1## wherein B is selected from the group consisting of --NHCOC(CH.sub.3).sub.3, 1,3-oxazolinyl and --CONHR, wherein R is methyl, phenyl, or t-butyl; Y is selected from the group consisting of CO.sub.2 H, CHO, CO.sub.2 R' and COR', wherein R' is a lower alkyl having from 1 to 4 carbon atoms; and A is H or tetrahydropyran. Said compounds are valuable intermediates in the preparation of certain anti-allergic chromone or thiochromone-5-oxamic acid derivatives.Type: GrantFiled: October 30, 1985Date of Patent: January 27, 1987Assignee: Miles Laboratories, Inc.Inventors: Trevor S. Abram, Peter Norman, Brian T. Warren
-
Patent number: 4633025Abstract: A method for preparing important stereospecific intermediates in the synthesis of prostaglandin analogs is disclosed. Said intermediates are (+)R-2-methyl-hexane-1,2-diol and (-)S-2-methyl-hexane-1,2-diol and are prepared via an asymmetric halolactonization reaction utilizing L-proline and D-proline, respectively as the chiral agent.Type: GrantFiled: January 8, 1986Date of Patent: December 30, 1986Assignee: Miles Laboratories, Inc.Inventor: Paul F. Corey
-
Patent number: 4629706Abstract: A method for determining allergenic sensitivity of a mammal is disclosed. The method involves measuring the time required for hemostasis of a blood sample with an allergen in the presence of a blood clotting inhibitor and comparing the time required for hemostasis in the presence of a blood clotting inhibitor and the absence of the allergen. The sensitivity to the allergen is determined by determining the difference in time required for hemostasis.Type: GrantFiled: June 20, 1984Date of Patent: December 16, 1986Assignee: Miles Laboratories, Inc.Inventors: Michael D. Hammond, William J. A. Taylor
-
Patent number: 4599340Abstract: A method for reducing soft tissue flap necrosis in a patient undergoing reconstructive surgery is disclosed. The method comprises administering to such patient an effective amount of a calcium channel blocking drug or a pharmaceutically acceptable non-toxic salt thereof to reduce said necrosis of said flap. Also disclosed are pharmaceutical compositions suitable for use in reducing soft tissue flap necrosis.Type: GrantFiled: May 7, 1985Date of Patent: July 8, 1986Assignee: Miles Laboratories, Inc.Inventors: Lester Silver, Barry Goldenberg
-
Patent number: 4571405Abstract: Certain 5-substituted chromones and thiochromones and pharmacologically acceptable salts thereof are disclosed. The compounds possess antiallergic properties and are represented by the formula: ##STR1## wherein: X is selected from the group consisting of --O--, --S--, and --SO.sub.2 --;R.sub.1 and R.sub.2 are each independently H or lower alkyl having from 1 to 4 carbon atoms or together with C.sub.2 and C.sub.3 from a cyclohexane ring having the structure: ##STR2## wherein R.sub.3 and R.sub.4 are each independently H or a lower alkyl having from 1 to 4 carbon atoms.Also taught are valuable intermediates useful in the preparation of said 5-substituted chromones and thiochromones represented by the formula: ##STR3## wherein B is selected from the group consisting of --NHCOC(CH.sub.3).sub.3, 1,3-oxazolinyl and --CONHR, wherein R is methyl, phenyl, or t-butyl; Y is selected from the group consisting of CO.sub.2 H, CHO, CO.sub.Type: GrantFiled: May 29, 1984Date of Patent: February 18, 1986Assignee: Miles Laboratories, Inc.Inventors: Trevor S. Abram, Peter Norman, Warren, Brian T.
-
Patent number: 4525495Abstract: The present invention is directed to mineral filled .alpha.-amino acid polymer composite materials. The composite materials are prepared by the in situ polymerization of an .alpha.-amino acid N-carboxyanhydride in the presence of mineral fillers which are optionally surface-modified with a partially hydrolyzed polyoxazoline prior to said polymerization. Composite materials prepared in this manner consist of an intimate mixture of polymer and mineral filler which may be optionally blended with a crosslinking agent and then molded to produce smooth, hard homogeneous materials that are water and oil resistant and have good heat distortion properties.Type: GrantFiled: July 22, 1983Date of Patent: June 25, 1985Assignee: The Dow Chemical CompanyInventors: Linneaus C. Dorman, Paul A. Meyers
-
Patent number: 4440943Abstract: 3,7-Substituted phenoxiodinin-5-ium compounds are effective against a variety of aerobic and anaerobic bacteria as well as fungi. The compounds of this invention may be prepared by the direct iodination of a suitably substituted diphenyl ether with iodosyl sulfate in concentrated sulfuric acid. The resulting bisulfate anion may be exchanged with a desired anion by standard metathetic processes.Type: GrantFiled: March 15, 1982Date of Patent: April 3, 1984Assignee: The Dow Chemical CompanyInventor: Edward E. Flagg