Patents Represented by Attorney, Agent or Law Firm Edward R. Gimmi
  • Methods for administering hypoglycemic agents
    Patent number: 8202837
    Abstract: The present invention relates to methods of administering hypoglycemic agents and/or GLP-1 agonists.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: June 19, 2012
    Assignee: GlaxoSmithKline LLC
    Inventors: Mark A. Bush, Mary Colleen O'Neill
  • System for providing communication between the interior and the exterior of a compartment
    Patent number: 7192065
    Abstract: A system for making a connection between the interior and exterior of a compartment, comprising a door opening through the compartment wall, a connector body which can engage with the wall, and having a connection port through it, and a removable cover on the connector body. The body is engaged with the door opening, and an inner door within the compartment engages and removes the cover. A preferred construction creates a single line of confidence seal. The system is particularly suited for sterile compartments.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: March 20, 2007
    Assignee: SmithKline Beecham Biologicals s.a.
    Inventors: Jacques Thilly, Christian Vandecasserie
  • Erythropoietin receptor antibodies
    Patent number: 6998124
    Abstract: Erythropoietin receptor agonist and antagonist antibodies and their use in enhancing erythropoiesis are disclosed.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: February 14, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Connie L. Erickson-Miller, Stephen D. Holmes, Alexander H. Taylor, Peter R. Young
  • Process to concentrate insoluble proteins by vibrating membrane filtration
    Patent number: 6939697
    Abstract: The present invention relates to a process for purifying proteins comprising applying protein extracts to a vibrating membrane fitter equipped with a hydrophilic membrane.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: September 6, 2005
    Assignee: GlaxoSmithKline Biologicals, s.a.
    Inventors: Benoit Champluvier, Philippe Jean Gervais Ghislain Permanne
  • ASP2
    Patent number: 6870030
    Abstract: ASP2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ASP2 polypeptides and polynucleotides in the design of protocols for the treatment of Alzheimer's Disease, cancer, and prohormone processing, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: March 22, 2005
    Assignees: Smithkline Beecham Corporation, Smithkline Beecham plc
    Inventors: David J. Powell, Conrad G. Chapman, Kay Murphy, Trudi S. Smith
  • Compounds and methods for the treatment of neoplastic disease
    Patent number: 6803369
    Abstract: A method of modulating the activity of a aberrant cell topoisomerase enzyme involving contacting the enzyme with a compound that inhibits enzyme-mediated cleavage of a polynucleotide substrate with which the enzyme is in complex. Pharmaceutical compositions containing such compounds may be used to treat neoplasias or to inhibit the growth of certain cancer cells. Screening methods can be employed to identify other compounds for these uses.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: October 12, 2004
    Assignees: SmithKline Beecham Corporation, SmithKlineBeecham p.l.c.
    Inventors: Symon G. Erskine, Michael Gwynn, Neil David Pearson, Edwina Imogen Wilding
  • Methods for producing modified nucleic acid molecules
    Patent number: 6770462
    Abstract: A method for inserting a cassette into a nucleic acid molecule to produce a modified nucleic acid molecule, e.g., a nucleic acid-cassette fusion, is described. The method involves the use of polymerase chain reaction, thereby permitting precise targeting of the desired site in the molecule, but does not require ligation. Also described is the use of this method for high throughput screening the resulting modified nucleic acid molecules.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: August 3, 2004
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Alison F. Chalker, David J. Holmes, Robert Dwayne Lunsford, James Yigong Ge
  • Monoclonal antibody and the method of using the antibody
    Patent number: 6706487
    Abstract: Chimeric, humanized and other IL-18 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: March 16, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Sherin S. Abdel-Meguid, Yen Sen Ho, Stephen D. Holmes, Alexander H. Taylor
  • Ornithine carbamoyltransferase
    Patent number: 6706508
    Abstract: The invention provides ornithine carbamoyltransferase polypeptides and DNA (RNA) encoding ornithine carbamoyltransferase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ornithine carbamoyltransferase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: March 16, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: James Raymond Brown, Magdalena Zalacain
  • Clavulanic acid dehydrogenase, preparation and use for the production of clavulanic acid
    Patent number: 6692950
    Abstract: A compound of formula (I), wherein R=H or Na, or a salt thereof and an enzyme, obtainable from Streptomyces species, having clavulanic acid dehydrogenase activity which is capable of converting (I) into clavulanic acid.
    Type: Grant
    Filed: April 3, 1996
    Date of Patent: February 17, 2004
    Assignee: SmithKline Beecham plc
    Inventors: Stephen William Elson, Neville Hubert Nicholson, Stefan Roland Woroniecki, Janice Arnell
  • Teat nozzle for dosing device with connection means
    Patent number: 6684918
    Abstract: A teat nozzle suitable for pediatric oral dosing of a fluid medicament comprising a tubular conduit which is engageable with a socket, and has at least one engagement part which can engage with an internal thread in the socket. The teat nozzle facilitates connection between the conduit and the socket. Dosing devices such as syringes and squeezable capsules provided with the nozzle, and a connection means for a vial having such a socket, are also described.
    Type: Grant
    Filed: December 13, 2001
    Date of Patent: February 3, 2004
    Assignee: SmithKline Beecham Biologicals s.a.
    Inventors: Jacques Thilly, Christian Vandecasserie
  • FabH
    Patent number: 6682919
    Abstract: The invention provides FabH polypeptides and polynucleotides encoding FabH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabH polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: January 27, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Christine Debouck, Daniel Robert Gentry, Deborah Dee Jaworski, John Timothy Londsdale, Jeffrey L Mooney, David John Payne, Stewart Campbell Pearson, Lisa Kathleen Schilling, Glenn Scott Van Aller, Min Wang, Yi Yi Zhong
  • Methods for treatment using novel ligands of the neuropeptide receptor HFGAN72
    Patent number: 6664229
    Abstract: Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose or treat diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: December 16, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: James Joseph Hagan, Jonathan Alexander Terrett, Neil Upton, David Piper, Martin Ian Smith, Guy Anthony Kennett, Saraswati R. Patel
  • NRDE
    Patent number: 6660520
    Abstract: The invention provides nrdE polypeptides and polynucleotides encoding nrdE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nrdE polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 5, 1998
    Date of Patent: December 9, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, Deborah Dee Jaworski, Anna Lisa Kosmatka, Lisa Kathleen Shilling, Min Wang, Edwina Imogen Wilding
  • Rnase P polypeptides, polynucleotides, and methods using their mechanisms of action
    Patent number: 6649744
    Abstract: This invention relates to a novel bacterial ribonucleoprotein complex and the component parts thereof. More specifically, this invention relates to RNase P RNA isolated from Staphylococcus aureus and the use of RNase P RNA in screens for the identification of antimicrobial compounds and to the use of such compounds in therapy.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: November 18, 2003
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham P.L.C.
    Inventors: Michael J. Gress, Lisa A Hegg, Hu Li, Joseph J. Park
  • CASB414:antigen overexpressed in several tumors
    Patent number: 6635255
    Abstract: CASB414 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CASB414 polypeptides and polynucleotides in diagnostics, and vaccines for prophylactic and therapeutic treatment of cancers, particularly colon cancers, autoimmune diseases, and related conditions.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: October 21, 2003
    Assignee: SmithKline Beecham Biologicals s.a.
    Inventors: Claudine Elvire Marie Bruck, Jean-Pol Cassart, Thierry Coche, Carlota Vinals Y De Bassols
  • Defl
    Patent number: 6586578
    Abstract: The invention provides Defl polypeptides and DNA (RNA) encoding Defl polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Defl polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 15, 1997
    Date of Patent: July 1, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Arthur Lonetto, Richard Lloyd Warren, Daniel Robert Sylvester
  • IL-18/IGIF chemotherapeutic compositions
    Patent number: 6582689
    Abstract: The present invention relates generally to compositions comprising potentiators, such as IL-18, also known as interferon-&ggr;-inducing factor (IGIF), in combination with a chemotherapeutic agent, processes for making such compositions, the use of such compositions for the prevention and/or treatment of cancer, and the use of such compositions to inhibit the growth of tumors or cancerous cells in mammals.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: June 24, 2003
    Assignee: Smithkline Beecham Corporation
    Inventor: Randall K. Johnson
  • Human uridine kinase
    Patent number: 6579708
    Abstract: Uridine kinase polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing uridine kinase polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: June 17, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Yen Sen Ho, Randall Johnson
  • Methods for ansamitocin production
    Patent number: 6573074
    Abstract: Improved purification methods for ansamitocins are disclosed.
    Type: Grant
    Filed: April 9, 2001
    Date of Patent: June 3, 2003
    Assignee: SmithKline Beecham plc
    Inventors: Mark Fulston, Anna L. Stefanska, Jan E. Thirkettle