Patents Represented by Attorney Edwards & Angell, LLP
  • Patent number: 7183037
    Abstract: The present invention provides new light absorbing compositions suitable for use as an antireflective coating (“ARC”) with an overcoated resist layer. ARCs of the invention exhibit increased etch rates in standard plasma etchants. Preferred ARCs of invention have significantly increased oxygen content relative to prior compositions.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: February 27, 2007
    Assignee: Shipley Company, L.L.C.
    Inventors: Zhibiao Mao, Suzanne Coley, Timothy G. Adams
  • Patent number: 7102677
    Abstract: A solid imaging device includes at least one pixel, the pixel including a photoelectric conversion section and a charge detection node which are coupled to or decoupled from each other via a transfer gate transistor, the charge detection node being coupled to or decoupled from a drain of a reset gate transistor via the reset gate transistor. After the reset gate resets a potential of the charge detection node, the transfer gate transistor is turned ON so as to allow a signal charge to be transferred from the photoelectric conversion section to the charge detection node, and thereafter a potential of the drain is changed from a HIGH state to a LOW state to a HIGH state while both of the transfer gate transistor and the reset gate transistor are maintained in an ON state.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: September 5, 2006
    Assignee: Sharp Kabushiki Kaisha
    Inventor: Takashi Watanabe
  • Patent number: 7087714
    Abstract: The present invention encompasses novel splice variant forms of the mu-opioid receptor-1 (MOR-1) and the polynucleotide sequences encoding the MOR-1 splice variants. The invention further encompasses methods of screening for compositions regulating the MOR-1 splice variant activities and the development of therapeutic modalities directed to regulating activity. Regulation of the MOR-1 splice variant activities may impact the physiologic process of analgesia.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: August 8, 2006
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Gavril W. Pasternak, Ying-Xian Pan
  • Patent number: 7087247
    Abstract: The invention relates to novel absorbable polyesters, produced by ring-opening polymerisation of hydroxycarboxylic acids in the presence of a polyol containing an electrolyte, in an extruder. In particular, the invention relates to novel polylactide glycolide polyesters which are essentially free of dextran sulphate and which are produced by ring-opening polymerisation of lactide and glycolide in the presence of dextran sulphate in the extruder; to the production of the same and to their use in depot medicaments.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: August 8, 2006
    Assignee: Creative Peptide Sweden AB
    Inventors: Youxin Li, Detlef Mohr, Tim Seiffert
  • Patent number: 7073510
    Abstract: Photochemical tissue bonding methods include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair and corneal repair.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: July 11, 2006
    Assignee: The General Hospital Corporation
    Inventors: Robert W. Redmond, Irene E. Kochevar
  • Patent number: 7070803
    Abstract: Novel controlled release pharmaceutical compositions for oral use containing midodrine and/or its active metabolite desglymidodrine. The novel compositions are designed to release midodrine and/or desglymidodrine after oral intake in a manner which enables absorption to take place in the gastrointestinal tract so that a relatively fast peak plasma concentration of the active metabolite desglymidodrine is obtained followed by a prolonged and relatively constant plasma concentration of desglymidodrine. The novel compositions may be designed for administration once or twice daily, i.e. a therapeutically effective concentration of desglymidodrine is maintained for a period of at least 10-16 hours followed by a wash out period of about 8-12 hours in order to avoid the well-known midodrine related side effect with respect to supine hypertension. The therapeutically effective concentration of desglymidodrine is regarded as a plasma concentration of desglymidodrine of at least about 3 ng/ml.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: July 4, 2006
    Assignee: Nycomed Austria GmbH
    Inventors: Annette Skinhøj, Peder Mohr Olsen, Poul Bertelsen
  • Patent number: 7071689
    Abstract: Featured are methods for magnetic resonance imaging in which MR signals of selected tissues, fluid or body components in a target area are desired to be essentially eliminated, which method includes applying an initial RF inversion pulse to invert the magnetization of the selected tissues or to apply any other T1 preparation aimed at nulling one or more tissue species and successively applying one or more RF inversions pulses thereafter. More particularly, the successively applied RF inversion pulses are applied so as to essentially maintain the magnetization of the selected tissues at or about the zero-crossing point of the longitudinal magnetization. Such methods further include interleaving a plurality of excitation pulses for acquiring image data and the RF inversion pulses so that at least one of the plurality of excitation pulses follows in a time sequence the application of one of the applied RF inversion pulses such that the image data is acquired following an inversion pulse.
    Type: Grant
    Filed: December 4, 2003
    Date of Patent: July 4, 2006
    Assignee: The Johns Hopkins University
    Inventors: Xavier Golay, Hanzhang Lu, Peter C. M. van Zijl
  • Patent number: 7072527
    Abstract: An image correction apparatus 1 includes an image input device 3, a memory device 4, a central processing unit 2, and and image output device 5. In the image correction apparatus 1, a locally wrinkled document or a document with a binding portion lifted differently between the top and bottom of the document is read from the image input device 3 and, using a program which is run on the central processing unit 2, an input image is corrected for the geometric distortion and luminance variations caused due to the upper and lower sides of the document making a slope with respect to a document platen, and thereby, a flat document image is restored.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: July 4, 2006
    Assignee: Sharp Kabushiki Kaisha
    Inventor: Kazuyuki Nako
  • Patent number: 7071581
    Abstract: Several embodiments of an uninterruptible power supply (UPS) system, which system provides highly reliable output power to a load using a slip-ring induction machine and a flywheel combination, are disclosed as well as methods relating thereto. In a preferred embodiment, the UPS system comprises a back-up power source, e.g., an engine and generator, and a slip-ring, or wound-rotor, induction motor and flywheel combination, which are in parallel to a primary power source, e.g., a utility grid. During normal operation of the UPS, the primary power source supplies alternating current and voltage to the load and the UPS compensates for voltage drop across the isolating inductor. Moreover, the primary power source keeps the slip-ring induction machine and flywheel in an excited state, i.e., the rotor of the slip-ring induction machine, the shaft of which is shared by the flywheel, is excited above normal synchronous speed.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: July 4, 2006
    Assignee: Satcon Technology Corp.
    Inventors: David B. Eisenhaure, James L. Kirtley, Jr., Laban Edward Lesster
  • Patent number: 7067514
    Abstract: This invention features pyrimidine compounds of formula (I): R1 is aryl, or heteroaryl; each of R2 and R4, independently, is Rc, halogen, nitro, cyano, isothionitro, SRc, or ORc; or R2 and R4, taken together, is carbonyl; R3 is Rc, alkenyl, alkynyl, ORc, OC(O)Rc, SO2Rc, S(O)Rc, S(O2)NRcRd, SRc, NRcRd, NRcCORd, NRcC(O)ORd, NRcC(O)NRcRd, NRcSO2Rd, CORc, C(O)ORc, or C(O)NRcRd; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is O, S, S(O), S(O2), or NRc; Y is a covalent bond, CH2, C(O), C?N—Rc, C?N—ORc, C?N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and each of Rc and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: June 27, 2006
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Mitsunori Ono, Shijie Zhang, Teresa Przewloka, Keizo Koya, Elena Kostik, Yuniko Wada, Lijun Sun, Weiwen Ying
  • Patent number: 7060413
    Abstract: The present invention provides radiation sensitive compositions and methods that comprise novel means for providing relief images of enhanced resolution. In one aspect the invention provides a method for controlling diffusion of photogenerated acid comprising adding a polar compound to a radiation sensitive composition and applying a layer of the composition to a substrate; exposing the composition layer to activating radiation whereby a latent image is generated comprising a distribution of acid moieties complexed with the polar compound; and treating the exposed composition layer to provide an activating amount of acid.
    Type: Grant
    Filed: February 20, 2004
    Date of Patent: June 13, 2006
    Assignee: Shipley Company, LLC
    Inventors: James W. Thackeray, Angelo A. Lamola
  • Patent number: 7056911
    Abstract: The invention relates to pharmaceutically active compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention and particularly useful for the treatment or prophylaxis of diseases associated with parasitic infection such as pneumocystis pneumonia, toxoplasmosis, cryptosporidiosis, leischmaniasis and malaria.
    Type: Grant
    Filed: January 25, 2000
    Date of Patent: June 6, 2006
    Assignee: Dana-Farber Cancer Institute
    Inventor: Andre Rosowsky
  • Patent number: 7053042
    Abstract: The invention provides novel peptide prodrugs that contain cleavage sites specifically cleaved by human kallikrein 2 (hK2). These prodrugs are useful for substantially inhibiting the non-specific toxicity of a variety of therapeutic drugs. Upon cleavage of the prodrug by hK2, the therapeutic drugs are activated and exert their toxicity. Methods for treating cell proliferative disorders are also featured in the invention.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: May 30, 2006
    Inventors: Samuel R. Denmeade, John T. Isaacs, Hans Lilja
  • Patent number: 7052793
    Abstract: The present invention relates to composite solid polymer electrolyte membranes (SPEMs) which include a porous polymer substrate interpenetrated with an ion-conducting material. SPEMs of the present invention are useful in electrochemical applications, including fuel cells and electrodialysis.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: May 30, 2006
    Assignee: Foster-Miller, Inc.
    Inventors: Richard M. Formato, Robert F. Kovar, Paul Osenar, Nelson Landrau, Leslie S. Rubin
  • Patent number: 7045517
    Abstract: This invention relates to triazine compounds of formula (I): R1 is , aryl, or heteroaryl; each of R2, R4, and R5, independently, is Rc, halogen, nitro, nitroso, cyano, azide, isothionitro, SRc, or ORc; R3 is Rc, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, ORc, OC(O)Rc, SO2Rc, S(O)Rc, S(O2)NRcRd, SRc, NRcRd, NRcCORd, NRcC(O)ORd, NRcC(O)NRcRd, NRcSO2Rd, CORc, C(O)ORc, or C(O)NRcRd; n is 0, 1, 2, 3, 4, 5, 6, or 7; X is O, S, S(O), S(O2), or NRc; Y is a covalent bond, CH2, C(O), C?N—Rc, C?N—ORc, C?N—SRc, O, S, S(O), or S(O2); Z is N; and W is O, S, S(O), S(O2), NRC, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and each of Rc and Rd, independently, is H, alkyl, or alkylcarbonyl.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: May 16, 2006
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: M. Ono, Lijun Sun, Shijie Zhang, Teresa Przewloka, David A. James, Wenli Ding, Yumiko Wada
  • Patent number: 7045497
    Abstract: The present invention relates to use of peptide to which G-protein coupled receptor protein recognizes as a ligand. Since the ligand polypeptide of the present invention has a stimulating action on oxytocin secretion, it is useful as a drug for ameliorating, preserving or treating various diseases related to oxytocin secretion such as uterine inertia, atonic hemorrhage, placental expulsion, subinvolution and the like.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: May 16, 2006
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hirokazu Matsumoto, Chieko Kitada, Shuji Hinuma
  • Patent number: 7038995
    Abstract: A lightweight, highly reliable optical pickup including a singlet objective lens is offered by correcting coma aberrations which adversely affect properties of the objective lens having an increased NA. A convergent optical system is composed of a singlet objective lens with a NA of 0.75 or more and includes an aberration-correcting optical system which corrects coma aberrations due to an inclination or shift of central axes of both surfaces of the objective lens or an inclination of the objective lens or the optical storage medium to an optical axis of the optical pickup.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: May 2, 2006
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Kazuya Kitamura, Yukio Kurata
  • Patent number: 7038144
    Abstract: An electronic component having an electrode structure to increase an allowance positional deviation in a mounting process as well as a method and a structure for mounting a semiconductor device are provided. The semiconductor device includes, on electrodes, connection materials connecting the semiconductor device and a substrate. The connection materials include a composite connection material formed of a core and a conductor covering the core, the core having an a low modulus of elasticity at room temperature smaller than that of the conductor at room temperature, and a single-layer connection material formed of a conductor.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: May 2, 2006
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Masao Yasuda, Masato Sumikawa
  • Patent number: 7034133
    Abstract: Novel oligomers, and synthesis thereof, comprising one or more bi-, tri, or polycyclic nucleoside analogues are disclosed herein. The nucleoside analogues have a “locked” structure, termed Locked Nucleoside Analogues (LNA). LNA's exhibit highly desirable and useful properties. LNA's are capable of forming nucleobase specific duplexes and triplexes with single and double stranded nucleic acids. These complexes exhibit higher thermostability than the corresponding complexes formed with normal nucleic acids. The properties of LNA's allow for a wide range of uses such as diagnostic agents and therapeutic agents in a mammal suffering from or susceptible to, various diseases.
    Type: Grant
    Filed: July 29, 2002
    Date of Patent: April 25, 2006
    Assignee: Exiqon A/S
    Inventors: Jesper Wengel, Poul Nielsen
  • Patent number: 7033778
    Abstract: The acetylation level of a peptide is determined utilizing the fact that the changes in the acetylation level are reflected in the sensitivity of the substrate peptide to a peptidase. This method can be used for measuring activities of deacetylase and acetylase, and also enables screening for substances that influence the activity of these enzymes. The deacetylase activity can be measured by a simple procedure according to the present invention.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: April 25, 2006
    Assignee: Cyclex Co., Ltd.
    Inventors: Katsuyuki Tamai, Toshiaki Miyazaki, Emi Wada, Ayumi Tatsuzawa
  • Patent number: 4929033
    Abstract: The proportioning valve assembly (40, 140) may be screwed into a complementary-shaped opening in a master cylinder (10). The valve assembly (40, 140) includes a differential area piston (50, 150) biased by a spring (70, 170) toward the outlet (21, 121) which communicates with the rear brakes. The master cylinder (10) includes a pair of passageways (16, 18) which communicate primary fluid pressure and secondary fluid pressure directly to the differential area piston (50, 150) of the proportioning valve assembly (40, 140) to displace the piston (50, 150) to a balanced position. If there is a failure of pressure in the primary brake circuit, the proportioning valve assembly (40, 140) actuates the differential area piston (50, 150) to permit fluid flow to bypass the piston (50, 150) and be communicated directly to the rear brakes of the vehicle.
    Type: Grant
    Filed: November 3, 1988
    Date of Patent: May 29, 1990
    Assignee: Allied-Signal Inc.
    Inventors: Richard A. Zander, Robert F. Gaiser, William F. Dillon, Jr., Donald A. Crumb