Abstract: The present invention relates to therapeutically active azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
Abstract: The present invention relates to therapeutically active azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
Abstract: The present invention relates to therapeutically active azacyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
Type:
Grant
Filed:
December 22, 1994
Date of Patent:
November 5, 1996
Assignee:
Novo Nordisk A/S
Inventors:
Per Sauerberg, Preben H. Olesen, Charles H. Mitch
Abstract: The present invention relates to catalases obtained from a strain of Scytalidium thermophilum or Humicola insolens which retains at least 75% residual activity after 20 minutes at 70.degree. C. and a pH in the range of 9.0-10.5 in the presence of 40 mM polyvinyl pyrrolidone and methods for producing and using same.
Type:
Grant
Filed:
September 15, 1993
Date of Patent:
November 5, 1996
Assignee:
Novo Nordisk A/S
Inventors:
Bj.o slashed.rn E. Christensen, Niels K. Lange, Kosaku Daimon
Abstract: The present invention relates to the treatment of dyed fabric comprising contacting, in an aqueous medium, the fabric with a cellulolytic enzyme and heat expanded perlite in an amount effective for providing localized variation in the color density of the surface of the dyed fabric. The present invention also relates to compositions comprising a cellulase, heat expanded perlite and a buffer and optionally a dispersing agent and/or a chelating agent.
Type:
Grant
Filed:
October 24, 1993
Date of Patent:
October 15, 1996
Assignee:
Novo Nordisk A/S
Inventors:
Thomas Videb.ae butted.k, Walter H. Westendorp
Abstract: Haemoglobin is crosslinked by means of transglutaminase, whereafter the transglutaminase is inactivated. The crosslinked haemoglobin can be used as a molecular agent for oxygen transportation, as an oxygen scavenger, and as a constituent of a food composition.
Abstract: Quinoxaline compounds of the general formula ##STR1## wherein R.sup.1 is COX', POX'X" or alkyl substituted with COX' or POX'X", and X' and X" independently are hydroxy or alkoxy, and R.sup.6, R.sup.7, R.sup.8 and R.sup.9 independently are hydrogen, alkyl, halogen, NH.sub.2, NO.sub.2, CN, CF.sub.3, SO.sub.2 NY'Y" or COZ' wherein Z' is NY'Y" or alkyl and Y' and Y" independently are hydrogen or alkyl, triazolyl, imidazolyl, imidazolyl substituted with phenyl or alkyl, or R.sup.6 and R.sup.7, or R.sup.8 and R.sup.9, together form a further fused ring, are useful in the treatment of indications caused by hyperactivity of the excitatory neurotransmitters.
Type:
Grant
Filed:
December 7, 1994
Date of Patent:
September 24, 1996
Assignee:
Novo Nordisk A/S
Inventors:
Poul Jacobsen, Flemming E. Nielsen, Lone Jeppesen
Abstract: The present invention relates to therapeutically active azacyclic compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
Type:
Grant
Filed:
May 30, 1995
Date of Patent:
September 24, 1996
Assignee:
Novo Nordisk A/S
Inventors:
Per Sauerberg, Preben H. Olesen, Charles H. Mitch
Abstract: The present invention relates to insulin crystals comprising ASP.sup.B28 and protamine, and pharmaceutical preparations containing same. The crystals and preparations exhibit rapid onset and prolonged activity when administered in vivo.
Abstract: A process for the preparation of a peroxycarboxylic acid of general formula (I), wherein R is an organic residue, in particular a linear or branched alkyled group, an aryl group or an alkyl aryl group each of which is optionally substituted with one or more groups, the process comprising treating a carboxylic acid of the general formula R--COOH, wherein R has the meaning indicated above, with hydrogen peroxide or a precursor thereof in the presence of an enzyme catalyst is described. The enzyme catalyst is preferably a hydrolase, such as a protease or a lipase. Also, a process for the oxidation of organic compounds with the peroxycarboxylic acids thus prepared is described.
Type:
Grant
Filed:
March 1, 1994
Date of Patent:
July 30, 1996
Assignee:
Novo Nordisk A/S
Inventors:
Ole Kirk, Frederik Bj orkling, Sven Erik Godtfredsen
Abstract: The present invention relates to rhamnogalacturonases derived from a strain of Aspergillus japonicus which (a) has a pH-optimum between 6.5 and 7.0; (b) retains at least 80% of the maximal activity throughout the pH range of 5.5-12; (c) has a temperature optimum of about 40.degree. C.; and (d) retains at least 80% of the maximal activity throughout the temperature range of 20.degree.-60.degree. C. The present invention relates to rhamnogalacturonases derived from a stain of Aspergillus aculeatus which (a) has a pH-optimum of about 5.0; (b) retains at least 80% of the maximal activity throughout the pH range of 3-6.5; (c) has a temperature optimum of about 40.degree. C.; and (d) retains at least 80% of the maximal activity throughout the temperature range of 5.degree.-50.degree. C.
Type:
Grant
Filed:
December 15, 1993
Date of Patent:
July 23, 1996
Assignee:
Novo Nordisk A/S
Inventors:
Kurt D orreich, Henrik Dalb.o slashed.ge, Jan M. Mikkelsen, Flemming M. Christensen, Torben Halkier