Patents Represented by Attorney, Agent or Law Firm Elias Lambiris Esq.
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Patent number: 6465209Abstract: The present invention relates to methods of producing protein hydrolysates, comprising adding to a proteinaceous material one or more aminopeptidase(s) having glycine releasing properties and one or more additional proteases wherein the amount of glycine produced is greater than the amount of glycine produced by the one or more additional proteases alone under the same conditions.Type: GrantFiled: May 15, 1998Date of Patent: October 15, 2002Assignees: Novozymes Biotech, Inc., Novozymes A/S, Japan Tobacco, Inc.Inventors: Alexander Blinkovsky, Kimberly Brown, Elizabeth Golightly, Tony Byun, Thomas E. Mathiasen, Lene V. Kofod, Mikio Fujii, Chigusa Marumoto
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Patent number: 6280995Abstract: The present invention relate to microbial pectate lyase, more specifically to microbial enzyme exhibiting pectate lyase activity as their major enzymatic activity in neutral and alkaline pH ranges, to a method of producing such an enzyme, and a method for using such enzymes in the textile, detergent, and cellulose fiber processing industries.Type: GrantFiled: April 11, 2000Date of Patent: August 28, 2001Assignee: Novozymes A/SInventors: Lene Nonboe Andersen, Martin Schülein, Niels Erik Krebs Lange
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Patent number: 6265185Abstract: Novel yeast promoters for either EF1-alpha protein or ribosomal protein S7 gene suitable for expression cloning in yeast and heterologous expression of proteins in yeast. The yeast promoters are preferably active in the pH range 4-11 without peptone and obtained from the yeast strain Yarrowia lipolytica.Type: GrantFiled: October 19, 1998Date of Patent: July 24, 2001Assignee: Novozymes A/S PatentsInventors: Sven Muller, Henrik Dalbøge
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Patent number: 6265197Abstract: The invention relates to a genetically engineered variant of a parent starch debranching enzyme, i.e. a pullulanase or an isamylase, the enzyme variant having an improved thermostability at a pH in the range of 4-6 compared to the parent enzyme and/or an increased activity towards amylopectin and/or glycogen compared to the parent enzyme, to methods for producing such starch debranching enzyme variants with improved thermostability and/or altered substrate specificity, and to a method for converting starch to one or more sugars using at least one such enzyme variant.Type: GrantFiled: July 1, 1999Date of Patent: July 24, 2001Assignee: Novozymes A/S KrogshoejvejInventors: Henrik Bisgård-Frantzen, Allan Svendsen
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Patent number: 6264925Abstract: The present invention relates to an oral care composition comprising a Cellulose Binding Domain and further ingredient conventionally used in oral care compositions, oral care products, and the use of CBDs for oral care purposes.Type: GrantFiled: April 8, 1999Date of Patent: July 24, 2001Assignee: Novozymes A/SInventors: Claus Crone Fuglsang, Rie Tsuchiya
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Patent number: 6258390Abstract: A process for making cheese including: a) adding to cheesemilk a transglutaminase, incubating for a suitable period, b) incubating with a rennet so as to cause clotting, and c) separating whey from the coagulate, and d) processing the coagulate into cheese. Cheese products produced by said process are contemplated and to the use of transglutaminase for maintaining proteins in the cheese material during a conventional cheese-making process.Type: GrantFiled: December 15, 1997Date of Patent: July 10, 2001Assignee: Novozymes A/S PatentsInventor: Peter Budtz
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Patent number: 6258769Abstract: A variant of a Coprinus cinereus peroxidase having one or more substitutions selected from M166L, V, I, F, Q and M242L, V, I, F, Q, wherein the parent peroxidase is encoded by the DNA sequence shown of SEQ ID:1.Type: GrantFiled: October 6, 1998Date of Patent: July 10, 2001Assignee: Novozymes A/S PatentsInventors: Karen Gjesing Welinder, Morten Birket Andersen
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Patent number: 6248134Abstract: The present invention provides a process for removal of excess dye from newly manufactured printed or dyed fabric or yarn, comprising treatment with a rinse liquor comprising at least one enzyme selected from the group consisting of enzymes exhibiting peroxidase activity or laccase activity, an oxidation agent, and at least one mediator selected from the group consisting of aliphatic, cyclo-aliphatic, heterocyclic or aromatic compounds containing the moiety >N—OH, in particular 1-hydroxybenzotriazole.Type: GrantFiled: February 8, 2000Date of Patent: June 19, 2001Assignees: Novozymes A/S, Bayer AGInventors: Ture Damhus, Uwe Vogt
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Patent number: 6221644Abstract: The present invention relates to isolated polypeptides having phytase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to composite feeds and methods of reducing phytate levels.Type: GrantFiled: September 30, 1998Date of Patent: April 24, 2001Assignee: Novo Nordisk Biotech, Inc.Inventors: Randy M. Berka, Michael W. Rey, Alan V. Klotz
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Patent number: 6207433Abstract: The present invention relates to isolated polypeptides having 5-aminolevulinic acid synthase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.Type: GrantFiled: January 4, 2000Date of Patent: March 27, 2001Assignee: Novo Nordisk Biotech, Inc.Inventor: Greg Gambetta
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Patent number: 6207430Abstract: The present invention relates to polypeptides having laccase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides.Type: GrantFiled: September 2, 1999Date of Patent: March 27, 2001Assignee: Novo Nordisk of Biotech, Inc.Inventors: Debbie Sue Yaver, Kimberley M. Brown, Sakari Kauppinen, Torben Halkier
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Patent number: 6200795Abstract: The present invention relates to isolated polypeptides having uroporphyrinogen decarboxylase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.Type: GrantFiled: November 16, 1998Date of Patent: March 13, 2001Assignee: Novo Nordisk Biotech, Inc.Inventor: Susan L. Elrod
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Patent number: 6197352Abstract: The staling of leavened baked products such as bread is retarded by adding an enzyme with exoamylase activity to the flour or dough used for producing the baked product in question.Type: GrantFiled: January 30, 1992Date of Patent: March 6, 2001Assignees: Novo Nordisk A/S, Novo AlleInventor: Tine Olesen
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Patent number: 6184028Abstract: The present invention relates to isolated polypeptides having pectin acetylesterase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.Type: GrantFiled: August 26, 1999Date of Patent: February 6, 2001Assignee: Novo Nordisk Biotech, Inc.Inventors: Michael D. Thomas, Kimberly M. Brown
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Patent number: 6180366Abstract: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a mutant of a parent filamentous fungal cell under conditions conducive for the production of the polypeptide, wherein (i) the mutant cell comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequence comprising a modification of at least one of the genes involved in the production of a trichothecene and (ii) the mutant produces less of the trichothecene than the parent filamentous fungal cell when cultured under the same conditions; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to mutants of filamentous fungal cells and methods for obtaining the mutant cells. The present invention also relates to isolated trichodiene synthases and isolated nucleic acid sequences encoding the trichodiene synthases.Type: GrantFiled: May 20, 1999Date of Patent: January 30, 2001Assignee: Novo Nordisk Biotech, Inc.Inventors: John C. Royer, Lynne M. Christianson, Gregory A. Gambetta, Howard Brody, Suzanne M. Otani, Wendy T. Yoder
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Patent number: 6146869Abstract: The present invention relates to isolated polypeptides having phospholipase B activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.Type: GrantFiled: October 21, 1999Date of Patent: November 14, 2000Assignee: Novo Nordisk Biotech, Inc.Inventors: Paul Harris, Kimberly M. Brown
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Patent number: 6129769Abstract: The present invention relates to methods for dyeing a material, comprising (a) treating the material with a dyeing system which comprises one or more reduced vat dyes and/or one or more reduced sulfur dyes; and (b) oxidizing the one or more reduced vat dyes or one or more reduced sulfur dyes adsorbed onto the treated material with an oxidation system comprising (i) an oxygen source and one or more enzymes exhibiting oxidase activity or (ii) a hydrogen peroxide source and one or more enzymes exhibiting peroxidase activity, to convert the one or more reduced dyes to their original oxidized insoluble colored forms; wherein the material is a fabric, yarn, fiber, garment or film made of cotton, diacetate, flax, fur, hide, leather, linen, lyocel, polyacrylic, polyamide, polyester, ramie, rayon, silk, tencel, triacetate, viscose or wool.Type: GrantFiled: August 24, 1999Date of Patent: October 10, 2000Assignee: Novo Nordisk Biotech, Inc.Inventors: Feng Xu, Sonja Salmon, Heinz-Josef Wilhelm Deussen, Henrik Lund
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Patent number: 6100057Abstract: The present invention relates to methods of producing hemoproteins comprising (a) introducing into a filamentous fungal cell, which is capable of producing the hemoprotein, (i) one or more first control sequences capable of directing the expression of a heme biosynthetic enzyme encoded by a first nucleic acid sequence endogenous to the filamentous fungal cell, wherein the one or more of the first control sequences are operably linked to the first nucleic acid sequence; and/or (ii) one or more copies of one or more second nucleic acid sequences encoding a heme biosynthetic enzyme; (b) cultivating the filamentous fungal cell in a nutrient medium suitable for production of the hemoprotein and the heme biosynthetic enzymes; and (c) recovering the hemoprotein from the nutrient medium of the filamentous fungal cell.Type: GrantFiled: June 9, 1997Date of Patent: August 8, 2000Assignee: Novo Nordisk Biotech, Inc.Inventors: Susan L. Elrod, Joel R. Cherry, Aubrey Jones
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Patent number: 6060468Abstract: The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.1a, R.sup.2, R.sup.2a, p, r and s are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to secretion and circulation of insulin antagonising peptides.Type: GrantFiled: October 3, 1997Date of Patent: May 9, 2000Assignee: Novo Nordisk A/SInventors: Tine Krogh J.o slashed.rgensen, Erik Fischer, Rolf Hohlweg, Knud Erik Andersen, Uffe Bang Olsen, Zdenek Polivka, Vladimir Valenta, Karel Sindelar
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Patent number: 6043247Abstract: The present invention relates to novel substituted acrylic acids, to methods for their preparation, compositions containing them, and their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to their use in diagnosis. The invention also relates to modulation of the activity of molecules with phospho-tyrosine recognition units, including protein tyrosine phosphatases (PTPases) and proteins with Src-homology-2 domains, in in vitro systems, microorganisms, eukaryotic cells, whole animals and human beings.Type: GrantFiled: April 16, 1997Date of Patent: March 28, 2000Assignee: Novo Nordisk A/SInventors: Henrik Sune Andersen, Niels Peter Hundahl M.o slashed.ller, Peter Madsen