Patents Represented by Attorney Elizabeth J. Ratner & Prestia Hecht
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Patent number: 6165751Abstract: HLDAT86 (Wnt-4) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HLDAT86 (Wnt-4) polypeptides and polynucleotides in the design of protocols for the treatment of kidney disorders, cancer, cardiac and vascular disease, inflammatory disorders, Alzheimers disease, schizophrenia and mood disorders., among others, and diagnostic assays for such conditions.Type: GrantFiled: April 28, 1998Date of Patent: December 26, 2000Assignee: SmithKline Beecham P.L.C.Inventor: Michael R Barnes
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Patent number: 6143521Abstract: Bombesin receptor subtype-3sb polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Bombesin receptor subtype-3sb polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: July 22, 1998Date of Patent: November 7, 2000Assignee: SmithKline Beecham CorporationInventors: Pamela Lane, Nabil Elshourbagy, Ping Tsui
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Patent number: 6130067Abstract: The EDG3sb polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EDG3sb polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: May 20, 1998Date of Patent: October 10, 2000Assignee: SmithKline Beecham CorporationInventor: Ping Tsui
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Patent number: 6127522Abstract: CRFG-1a polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CRFG-1a polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal disease, renal ischemia, diabetic nephropathy, acute renal failure, Neurodegenerative disease, and Alzeimer's disease, among others, and diagnostic assays for such conditions.Type: GrantFiled: November 16, 1998Date of Patent: October 3, 2000Assignee: SmithKline Beecham CorporationInventors: Nicholas J Laping, Barbara Olson, Yuan Zhu
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Patent number: 6110717Abstract: The hRCE1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hRCE1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: February 12, 1998Date of Patent: August 29, 2000Assignees: SmithKline Beecham Corporation, SmithKline Beecham plcInventors: Kristine Kay Kikly, Anne M Knab, Christopher Donald Southan
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Patent number: 6107473Abstract: HTHBZ47 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HTHBZ47 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: March 16, 1998Date of Patent: August 22, 2000Assignee: SmithKline Beecham CorporationInventors: Earl Francis Albone, Kristine Kay Kikly
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Patent number: 6100059Abstract: HGBAB90 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HGBAB90 polypeptides and polynucleotides in the design of protocols for the treatment of pulmonary emphysema, arthritis, multiple sclerosis, periodontal disease, cystic fibrosis, respiratory disease, thrombosis, cancer, cachexia, angina, glaucoma, inflamatory disorders, osteoporosis, cardiovascular disorders such as hypertension, atherosclerotic disorders such as cardiac infarction, and stroke, asthma, psoriasis, chronic neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's, demyelinating diseases, AIDS immune deficiency, disorders of photoreceptor degeneration, and lens cataract formation, organ transplant rejection, cataracts, restenosis, muscular dystrophy, renal failure, cerebral vasospasm, pancreatitis, and diabetic nephropathy, among others, and diagnostic assays for such conditions.Type: GrantFiled: April 30, 1998Date of Patent: August 8, 2000Assignee: SmithKline Beecham p.l.c.Inventors: Christopher Donald Southan, Helen Elizabeth Clinkenbeard, Nicola Anne Burgess
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Patent number: 6074845Abstract: BECRLR polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing BECRLR polypeptides and polynucleotides in screening assays to discover compounds that either agonize or antagonize the biological activity of the receptor.Type: GrantFiled: January 28, 1999Date of Patent: June 13, 2000Assignee: SmithKline Beecham CorporationInventors: Nambi V. Aiyar, Jyoti Disa
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Patent number: 6063609Abstract: The Serum Inducible Kinase (Snk) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Serum Inducible Kinase (Snk) polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: August 20, 1998Date of Patent: May 16, 2000Assignee: SmithKline Beecham CorporationInventors: Karen M Anderson, Mark M Bouzyk, Michael J Hansbury, Jeffrey R Jackson, Sandhya S Nerurkar, Amy K Roshak
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Patent number: 6054559Abstract: IL-1ra beta polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1ra beta polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, septicemia, arthritis, inflammatory bowel disease, graft vs. host disease, autoimmunity, stroke, cardiac ischemia, acute respiratory disease syndrome (ARDS), psoriasis, restenosis, traumatic brain injury, AIDS, cachexia, allergy, parasite infection, allergic rhinitis, allergic asthma, atopic dermatitis, allergic inflammatory diseases, and delayed hypersensitivity., among others, and diagnostic assays for such conditions.Type: GrantFiled: April 29, 1998Date of Patent: April 25, 2000Assignee: SmithKline Beecham CorporationInventor: Peter R. Young
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Patent number: 6051400Abstract: Patched-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Patched-2 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: May 20, 1998Date of Patent: April 18, 2000Assignee: SmithKline Beecham plcInventors: David P Kelsell, Michael R Barnes, Tania Tamson Testa
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Patent number: 6043054Abstract: GABA BP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing GABA BP polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: October 30, 1998Date of Patent: March 28, 2000Assignees: SmithKline Beecham Corporation, SmithKline Beecham plcInventors: Lisa Vawter, Melanie Stammers
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Patent number: 6033873Abstract: This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein CSBP.beta., to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.Type: GrantFiled: November 10, 1998Date of Patent: March 7, 2000Assignee: Smithkline Beecham CorporationInventors: Peter Colon McDonnell, Peter Ronald Young
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Patent number: 6031090Abstract: GPR31A polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing GPR31A polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: August 7, 1998Date of Patent: February 29, 2000Assignee: SmithKline Beecham CorporationInventors: Nabil Elshourbagy, Usman Shabon
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Patent number: 6001623Abstract: The H2LAU20 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing H2LAU20 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: July 31, 1998Date of Patent: December 14, 1999Assignee: SmithKline Beecham CorporationInventors: Kimberly Anne Brun, Caretha Lee Creasy, Damien John Dunnington
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Patent number: 6001972Abstract: EBI 3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EBI 3 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia, bulimia, asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.Type: GrantFiled: October 26, 1998Date of Patent: December 14, 1999Assignee: SmithKline Beecham CorporationInventor: Yuan Zhu
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Patent number: 5994100Abstract: HOEFC11 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HOEFC11 polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal failure, inflammatory diseases, myocardial ischemia, cancer, rheumatoid arthritis, cirrhotic liver disease, among others, and diagnostic assays for such conditions.Type: GrantFiled: May 29, 1997Date of Patent: November 30, 1999Assignee: SmithKline Beecham CorporationInventors: Yuan Zhu, Ponnal Nambi, Mark A Pullen
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Patent number: 5981223Abstract: HDPXU17 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HDPXU17 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infraction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.Type: GrantFiled: January 20, 1998Date of Patent: November 9, 1999Assignee: SmithKline Beecham CorporationInventors: Ganesh M Sathe, Wendy S Halsey, Derk J Bergsma
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Patent number: 5955309Abstract: H7TBA62 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing H7TBA62 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.Type: GrantFiled: October 27, 1997Date of Patent: September 21, 1999Assignee: Smithkline Beecham CorporationInventors: Catherine E Ellis, Ganesh M Sathe
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Patent number: 5955308Abstract: HEOAD54 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HEOAD54 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infraction; ulcers;astma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourettt's syndrome, among others, and diagnostic assays for such conditions.Type: GrantFiled: October 23, 1997Date of Patent: September 21, 1999Assignee: SmithKline Beecham CorporationInventors: Derk J Bergsma, Wendy S Halsey, Jeffrey L Mooney, Ganesh M Sathe