Patents Represented by Attorney Elizabeth J. Ratner & Prestia Hecht
  • Patent number: 6165751
    Abstract: HLDAT86 (Wnt-4) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HLDAT86 (Wnt-4) polypeptides and polynucleotides in the design of protocols for the treatment of kidney disorders, cancer, cardiac and vascular disease, inflammatory disorders, Alzheimers disease, schizophrenia and mood disorders., among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: April 28, 1998
    Date of Patent: December 26, 2000
    Assignee: SmithKline Beecham P.L.C.
    Inventor: Michael R Barnes
  • Patent number: 6143521
    Abstract: Bombesin receptor subtype-3sb polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Bombesin receptor subtype-3sb polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: July 22, 1998
    Date of Patent: November 7, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Pamela Lane, Nabil Elshourbagy, Ping Tsui
  • Patent number: 6130067
    Abstract: The EDG3sb polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EDG3sb polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: May 20, 1998
    Date of Patent: October 10, 2000
    Assignee: SmithKline Beecham Corporation
    Inventor: Ping Tsui
  • Patent number: 6127522
    Abstract: CRFG-1a polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CRFG-1a polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal disease, renal ischemia, diabetic nephropathy, acute renal failure, Neurodegenerative disease, and Alzeimer's disease, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: November 16, 1998
    Date of Patent: October 3, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicholas J Laping, Barbara Olson, Yuan Zhu
  • Patent number: 6110717
    Abstract: The hRCE1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hRCE1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: February 12, 1998
    Date of Patent: August 29, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Kristine Kay Kikly, Anne M Knab, Christopher Donald Southan
  • Patent number: 6107473
    Abstract: HTHBZ47 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HTHBZ47 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: March 16, 1998
    Date of Patent: August 22, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Earl Francis Albone, Kristine Kay Kikly
  • Patent number: 6100059
    Abstract: HGBAB90 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HGBAB90 polypeptides and polynucleotides in the design of protocols for the treatment of pulmonary emphysema, arthritis, multiple sclerosis, periodontal disease, cystic fibrosis, respiratory disease, thrombosis, cancer, cachexia, angina, glaucoma, inflamatory disorders, osteoporosis, cardiovascular disorders such as hypertension, atherosclerotic disorders such as cardiac infarction, and stroke, asthma, psoriasis, chronic neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's, demyelinating diseases, AIDS immune deficiency, disorders of photoreceptor degeneration, and lens cataract formation, organ transplant rejection, cataracts, restenosis, muscular dystrophy, renal failure, cerebral vasospasm, pancreatitis, and diabetic nephropathy, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: August 8, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Christopher Donald Southan, Helen Elizabeth Clinkenbeard, Nicola Anne Burgess
  • Patent number: 6074845
    Abstract: BECRLR polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing BECRLR polypeptides and polynucleotides in screening assays to discover compounds that either agonize or antagonize the biological activity of the receptor.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: June 13, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Nambi V. Aiyar, Jyoti Disa
  • Patent number: 6063609
    Abstract: The Serum Inducible Kinase (Snk) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Serum Inducible Kinase (Snk) polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: May 16, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Karen M Anderson, Mark M Bouzyk, Michael J Hansbury, Jeffrey R Jackson, Sandhya S Nerurkar, Amy K Roshak
  • Patent number: 6054559
    Abstract: IL-1ra beta polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1ra beta polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, septicemia, arthritis, inflammatory bowel disease, graft vs. host disease, autoimmunity, stroke, cardiac ischemia, acute respiratory disease syndrome (ARDS), psoriasis, restenosis, traumatic brain injury, AIDS, cachexia, allergy, parasite infection, allergic rhinitis, allergic asthma, atopic dermatitis, allergic inflammatory diseases, and delayed hypersensitivity., among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: April 29, 1998
    Date of Patent: April 25, 2000
    Assignee: SmithKline Beecham Corporation
    Inventor: Peter R. Young
  • Patent number: 6051400
    Abstract: Patched-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Patched-2 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: May 20, 1998
    Date of Patent: April 18, 2000
    Assignee: SmithKline Beecham plc
    Inventors: David P Kelsell, Michael R Barnes, Tania Tamson Testa
  • Patent number: 6043054
    Abstract: GABA BP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing GABA BP polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: March 28, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Lisa Vawter, Melanie Stammers
  • Patent number: 6033873
    Abstract: This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein CSBP.beta., to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.
    Type: Grant
    Filed: November 10, 1998
    Date of Patent: March 7, 2000
    Assignee: Smithkline Beecham Corporation
    Inventors: Peter Colon McDonnell, Peter Ronald Young
  • Patent number: 6031090
    Abstract: GPR31A polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing GPR31A polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: August 7, 1998
    Date of Patent: February 29, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Nabil Elshourbagy, Usman Shabon
  • Patent number: 6001623
    Abstract: The H2LAU20 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing H2LAU20 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: December 14, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Kimberly Anne Brun, Caretha Lee Creasy, Damien John Dunnington
  • Patent number: 6001972
    Abstract: EBI 3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EBI 3 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia, bulimia, asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: October 26, 1998
    Date of Patent: December 14, 1999
    Assignee: SmithKline Beecham Corporation
    Inventor: Yuan Zhu
  • Patent number: 5994100
    Abstract: HOEFC11 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HOEFC11 polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal failure, inflammatory diseases, myocardial ischemia, cancer, rheumatoid arthritis, cirrhotic liver disease, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: November 30, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Yuan Zhu, Ponnal Nambi, Mark A Pullen
  • Patent number: 5981223
    Abstract: HDPXU17 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HDPXU17 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infraction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: November 9, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Ganesh M Sathe, Wendy S Halsey, Derk J Bergsma
  • Patent number: 5955309
    Abstract: H7TBA62 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing H7TBA62 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: September 21, 1999
    Assignee: Smithkline Beecham Corporation
    Inventors: Catherine E Ellis, Ganesh M Sathe
  • Patent number: 5955308
    Abstract: HEOAD54 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HEOAD54 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infraction; ulcers;astma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourettt's syndrome, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: October 23, 1997
    Date of Patent: September 21, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk J Bergsma, Wendy S Halsey, Jeffrey L Mooney, Ganesh M Sathe