Patents Represented by Attorney, Agent or Law Firm Elizabeth M. Anderson
  • Naphthyridine antibacterial agents
    Patent number: 5281612
    Abstract: Novel naphthyridine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.
    Type: Grant
    Filed: May 27, 1988
    Date of Patent: January 25, 1994
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Thomas F. Mich, Jeffrey B. Nichols
  • N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives
    Patent number: 5278316
    Abstract: Novel unnatural dipeptoids of .alpha.-substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further the compounds are antianxiety agents, antiulcer agents, antidepressant agents, and are agents useful for preventing the withdrawal response produced by chronic treatment or use followed by chronic treatment followed by withdrawal from nicotine, diazepam, alcohol, cocaine, caffeine, or opiods. Also disclosed are pharmaceutical compositions and methods of treatment using the dipeptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare pharmaceutical and diagnostic compositions.
    Type: Grant
    Filed: December 19, 1990
    Date of Patent: January 11, 1994
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, Martyn C. Pritchard, Reginald S. Richardson, Edward Roberts, Julian Aranda
  • Polycyclic amines useful as cerebrovascular agents
    Patent number: 5276053
    Abstract: A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.
    Type: Grant
    Filed: October 6, 1992
    Date of Patent: January 4, 1994
    Assignee: Warner-Lambert Company
    Inventor: Graham Johnson
  • 4-(1H-pyrrol-1-yl)imidazoles with angiotensin II antagonist activity
    Patent number: 5276048
    Abstract: Novel substituted 4-(1-H-pyrrol-1-yl)imidazoles are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and methods of using them. Novel intermediates useful in the preparation of the compounds of the invention are also disclosed and synthetic methods for preparing the novel intermediates. The compounds are useful as antagonists of angiotensin II and thus are useful in the control of hypertension, hyperaldosteronism, congestive heart failure, glaucoma, vascular smooth muscle proliferation associated with atherosclerosis, and with postsurgical vascular restenosis.
    Type: Grant
    Filed: October 13, 1992
    Date of Patent: January 4, 1994
    Assignee: Warner-Lambert Company
    Inventors: John C. Hodges, John G. Topliss
  • N-substituted cycloalkyl and polycycloalkyl .alpha.-substituted TRP derivatives
    Patent number: 5264419
    Abstract: Novel peptoids of .alpha.-substituted Trp derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to withdrawal from chronic treatment or use of nicotine, diazepam, alcohol, cocaine, caffeine, or opioids. The compounds are also useful in the treatment and/or prevention of panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the peptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare diagnostic compositions.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: November 23, 1993
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, Martyn C. Pritchard, Edward Roberts
  • Diol-containing renin inhibitors
    Patent number: 5260278
    Abstract: The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the peptides, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, or hyperaldosteronism.
    Type: Grant
    Filed: April 1, 1991
    Date of Patent: November 9, 1993
    Assignee: Warner-Lambert Company
    Inventors: Richard Himmelsbach, John C. Hodges, James S. Kaltenbronn, William C. Patt, Joseph T. Repine, Ila Sircar
  • Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
    Patent number: 5246943
    Abstract: This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful in the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhancement, in atherosclerosis and in treating excessive AVP secretory disorders. Novel intermediates useful in the preparation of the compounds are also disclosed. Methods of using the compounds and pharmaceutical compositions containing them are disclosed.
    Type: Grant
    Filed: May 19, 1992
    Date of Patent: September 21, 1993
    Assignee: Warner-Lambert Company
    Inventors: Clifton J. Blankley, John C. Hodges, Sylvester Klutchko
  • N-substituted cycloalkyl and polycycloalkyl polyhydro-.beta.-carboline-phenylalanine- and phenethylamine derivatives
    Patent number: 5244905
    Abstract: Novel substituted polyhydro-.beta.-carboline derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotic agents are disclosed. Further the compounds are antianxiety agents and antiulcer agents. Further, the compounds are useful for treating and/or preventing panic attacks. They are agents useful for preventing the response to withdrawal from chronic treatment with or use of nicotine, caffeine, diazepam, alcohol, cocaine or opioids. Also disclosed are pharmaceutical compositions and methods of treatment using the compounds as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds in diagnostic compositions.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: September 14, 1993
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, Edward Roberts, Uwe Trostmann
  • Amico acid derivatives cyclized at the C-terminal
    Patent number: 5244915
    Abstract: Novel .alpha.-substituted Trp dipeptoid derivatives cyclized at the C-terminal useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment with or use of nicotine, diazepam, alcohol, cocaine, caffeine, or opioids. The compounds of the invention are also useful in treating and/or preventing panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the compounds as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the compounds in diagnostic compositions.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: September 14, 1993
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, Martyn C. Pritchard, Reginald S. Richardson, Edward Roberts
  • Process for preparing tetracyclic amines useful as cerebrovascular agents
    Patent number: 5245028
    Abstract: Processes for the preparation of a series of tetracyclic amines useful in the treatment and/or prevention of cerebrovascular disorders are disclosed.
    Type: Grant
    Filed: September 3, 1991
    Date of Patent: September 14, 1993
    Assignee: Warner-Lambert Company
    Inventor: Thomas C. Malone
  • Anilide derivatives with angiotensin II antagonist properties
    Patent number: 5242939
    Abstract: This invention relates to anilide derivatives of Formula I ##STR1## which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of hypertension, heart failure, glaucoma, and hyperaldosteronism. Methods of making the compounds, novel intermediates useful in the preparation of the compounds, compositions containing the compounds and methods of using them are also covered.
    Type: Grant
    Filed: September 13, 1991
    Date of Patent: September 7, 1993
    Assignee: Warner-Lambert Company
    Inventor: Ila Sircar
  • Amino-substituted heterocycles as renin inhibitors
    Patent number: 5238923
    Abstract: The invention concerns novel renin-inhibitory compounds which contain an amino-substituted heterocycle at the P.sub.2 position. These are useful for treating renin-associated hypertension, congestive heart failure, glaucoma, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the compounds, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, or hyperaldosteronism.
    Type: Grant
    Filed: April 25, 1990
    Date of Patent: August 24, 1993
    Assignee: Warner-Lambert Company
    Inventors: Cleo Connolly, Annette M. Doherty, Harriet W. Hamilton, William C. Patt, Ila Sircar
  • Renin inhibiting peptides having an .alpha.-heteroatom amino acid at the P.sub.3 position
    Patent number: 5221667
    Abstract: The invention concerns novel renin-inhibitory compounds which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, glaucoma, and diseases caused by retroviruses including HTLV-I -II, and -III. Processes for preparing the compounds, novel intermediates useful in the preparation thereof, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.
    Type: Grant
    Filed: January 22, 1990
    Date of Patent: June 22, 1993
    Assignee: Warner-Lambert Company
    Inventors: James S. Kaltenbronn, Joseph T. Repine
  • Tetrahydroisoquinoline-type renin inhibiting peptides
    Patent number: 5219851
    Abstract: The invention concerns novel renin-inhibitory compounds which contain a tetrahydroisoquinoline or similar heterocycle at the P.sub.3 position. These are useful for treating hypertension, congestive heart failure, glaucoma, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I, -II and -III. Processes for preparing the compounds, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, or hyperaldosteronism.
    Type: Grant
    Filed: March 5, 1991
    Date of Patent: June 15, 1993
    Assignee: Warner-Lambert Company
    Inventors: Harriet W. Hamilton, William C. Patt
  • Didehydrotryptophan derivatives and pharmaceutical use thereof
    Patent number: 5218123
    Abstract: Novel didehydrotryptophan derivatives useful as agents in the reduction of gastric acid secretion and in the treatment of anxiety, psychoses, and the symptoms of cognitive decline are disclosed. Processes for making the compounds and novel intermediates useful in the processes as well as compositions containing the compounds and methods of using them are also disclosed.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: June 8, 1993
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, Martyn C. Pritchard
  • Cholecystokinin antagonists useful for treating depression
    Patent number: 5217957
    Abstract: The invention concerns cholecystokinin (CCK) antagonists useful in the treatment major and minor forms of depression. CCK-B, -A, and mixed -A and -B antagonists are useful. Especially useful are CCK.sub.B antagonists such as CI-988.
    Type: Grant
    Filed: August 20, 1991
    Date of Patent: June 8, 1993
    Assignee: Warner-Lambert Company
    Inventor: Geoffrey N. Woodruff
  • 4-(1H-pyrrol-1-yl) imidazoles with angiotension II antagonist activity
    Patent number: 5210211
    Abstract: Novel substituted 4-(1-H-pyrrol-1-yl)imidazoles are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and methods of using them. Novel intermediates useful in the preparation of the compounds of the invention are also disclosed and synthetic methods for preparing the novel intermediates. The compounds are useful as antagonists of angiotensin II and thus are useful in the control of hypertension, hyperaldosteronism, congestive heart failure, glaucoma, vascular smooth muscle proliferation associated with atherosclerosis, and with postsurgical vascular restenosis.
    Type: Grant
    Filed: May 19, 1992
    Date of Patent: May 11, 1993
    Assignee: Warner-Lambert Company
    Inventors: John C. Hodges, John G. Topliss
  • Renin inhibitors containing C-terminal dihydroxy amides
    Patent number: 5198426
    Abstract: The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, glaucoma and diseases caused by retroviruses. Processes for preparing the peptides novel intermediates in the processes, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, or hyperaldosteronism.
    Type: Grant
    Filed: December 4, 1989
    Date of Patent: March 30, 1993
    Assignee: Warner-Lambert Company
    Inventors: James M. Hamby, John C. Hodges, Sylvester Klutchko
  • Alkoxy-4(1H)-pyridone derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
    Patent number: 5185352
    Abstract: The invention concerns new derivatives of certain alkoxy -4(1H)-pyridones, processes for preparing them, and pharmaceutical compositions containing them. The compounds of the invention are useful in the prevention and/or treatment of heart and blood vessel diseases such as thromboses, arteriosclerosis and hypertension, and of inflammatory processes, allergies, cancers, and certain degenerative damage of the central nervous system.
    Type: Grant
    Filed: January 28, 1991
    Date of Patent: February 9, 1993
    Assignee: Goedecke Aktiengesellschaft
    Inventors: Julian Aranda, Johannes Hartenstein, Reinhard Reck, Christopher Schachtele, Claus Rudolph, Hartmut Osswald, Gunter Weinheimer
  • Polycyclic amines useful as cerebrovascular agents
    Patent number: 5180736
    Abstract: A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.
    Type: Grant
    Filed: May 17, 1991
    Date of Patent: January 19, 1993
    Assignee: Warner-Lambert Company
    Inventor: Graham Johnson