Patents Represented by Attorney Elizabeth Manning
  • Patent number: 4933168
    Abstract: A unique crystalline polymorphic form of flunisolide is disclosed which is stable in aerosols such as Freon.RTM. mixtures and is valuable in the treatment of respiratory diseases, particularly bronchial asthma and allergic rhinitis.
    Type: Grant
    Filed: September 14, 1981
    Date of Patent: June 12, 1990
    Assignee: Syntex Pharmaceuticals International Limited
    Inventors: Richard E. Jones, Gisela T. Haringer
  • Patent number: 4532355
    Abstract: Novel 9-phenyl 5,6-dimethyl-nona-2,4,6,8-tetraenoic acid,-tetraenal or tetraenol derivatives useful as anti-tumor agents.
    Type: Grant
    Filed: September 13, 1982
    Date of Patent: July 30, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Werner Bollag, Rudolf Ruegg, Gottlieb Ryser
  • Patent number: 4526704
    Abstract: Compounds of the formula ##STR1## wherein n is 0 or 1; one of X.sup.1 and X.sup.2 is --COO-- or --OOC-- and the other is a single covalent bond or --CH.sub.2 CH.sub.2 --; X.sup.3 and X.sup.4 individually are a single covalent bond or --CH.sub.2 CH.sub.2 --, with the proviso that at most one of X.sup.1, X.sup.2, X.sup.3 and X.sup.4 is --CH.sub.2 CH.sub.2 --; rings A.sup.1 and A.sup.5 individually are a group of the formula ##STR2## or trans-1,4-cyclohexylene; rings A.sup.2, A.sup.3 and A.sup.4 individually are a group of formula II or, when ring A.sup.2, A.sup.3 or A.sup.4 is not linked with at least one of the other two of these rings by a single covalent bond then such ring also can be trans-1,4-cyclohexylene, with the proviso that at least one of rings A.sup.1 through A.sup.5 is a group of formula II; Y is hydrogen, or when Y is attached to a ring of formula II which is not linked with another ring via a single covalent bond, Y also can be fluorine, chlorine or methyl; and R.sup.1 and R.sup.
    Type: Grant
    Filed: July 11, 1983
    Date of Patent: July 2, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Martin Petrzilka, Martin Schadt, Alois Villiger
  • Patent number: 4454152
    Abstract: This invention relates to oral dosage forms wherein the active ingredient, methoxsalen, is dispersed in a water-soluble composition containing a polyethylene glycol or mixtures of polyethylene glycols. Dissolution of methoxsalen in gastrointestinal fluids as well as drug absorption are more rapid and higher blood level patterns are achieved with these dosage forms as compared to conventional encapsulated dosage forms.
    Type: Grant
    Filed: December 21, 1981
    Date of Patent: June 12, 1984
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard H. Barry, Jack H. Lazarus