Patents Represented by Attorney, Agent or Law Firm Ellen J. Kapinos
  • Bone morphogenetic protein-3 and compositions
    Patent number: 6432919
    Abstract: Purified BMP-3 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: March 4, 1991
    Date of Patent: August 13, 2002
    Assignee: Genetics Institute, Inc.
    Inventors: Elizabeth A. Wang, John M. Wozney, Vicki Rosen
  • Neuronal uses of BMP-11
    Patent number: 6340668
    Abstract: Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction and/or maintenance of bone, cartilage and/or other connective tissue, and/or neuronal tissue.
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: January 22, 2002
    Assignee: Genetics Institute, Inc.
    Inventors: Anthony J. Celeste, John M. Wozney, R. Scott Thies
  • Bone morphogenic protein-16 (BMP-16) compositions
    Patent number: 6331612
    Abstract: Purified BMP-16 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-16 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
    Type: Grant
    Filed: June 9, 1999
    Date of Patent: December 18, 2001
    Assignee: Genetics Institute, Inc.
    Inventors: Anthony J. Celeste, Beth L. Murray
  • BMP receptor proteins
    Patent number: 6291206
    Abstract: Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding said proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to said BMP receptor proteins.
    Type: Grant
    Filed: September 17, 1993
    Date of Patent: September 18, 2001
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Anthony J. Celeste, R. Scott Thies, Noboru Yamaji
  • BMP-9 compositions
    Patent number: 6287816
    Abstract: Purified bone morphogenetic protein-9 (BMP-9) proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: September 11, 2001
    Assignee: Genetics Institute, Inc.
    Inventors: Vicki A. Rosen, John M. Wozney, Anthony J. Celeste, R. Scott Thies, Jeffrey R. Song
  • BMP-4 products
    Patent number: 6245889
    Abstract: Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: September 9, 1997
    Date of Patent: June 12, 2001
    Assignee: Genetics Institute, Inc.
    Inventors: Elizabeth A. Wang, John M. Wozney, Vicki A. Rosen
  • BMP-6 proteins
    Patent number: 6207813
    Abstract: Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: November 9, 1998
    Date of Patent: March 27, 2001
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Elizabeth A. Wang, Vicki A. Rosen, Anthony J. Celeste
  • BMP products
    Patent number: 6150328
    Abstract: Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: June 14, 1991
    Date of Patent: November 21, 2000
    Assignee: Genetics Institute, Inc.
    Inventors: Elizabeth A. Wang, John M. Wozney, Vicki A. Rosen
  • Bone morphogenetic protein (BMP)-9 compositions and their uses
    Patent number: 6034062
    Abstract: Purified Bone Morphogenetic Protein (BMP)-9 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair, and in hepatic growth and function.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: March 7, 2000
    Assignee: Genetics Institute, Inc.
    Inventors: R. Scott Thies, Jeffrey J. Song
  • BMP-9 compositions
    Patent number: 6034061
    Abstract: Purified Bone Morphogenetic Protein (BMP)-9 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair, and in hepatic growth and function.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: March 7, 2000
    Assignee: Genetics Institute, Inc.
    Inventors: Vicki A. Rosen, John M. Wozney, Anthony J. Celeste, Scott R. Thies, Jeffrey R. Song
  • Methods of administering BMP-5 compositions
    Patent number: 5939388
    Abstract: Purified BMP-5 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: August 17, 1999
    Inventors: Vicki A. Rosen, John M. Wozney, Elizabeth A. Wang
  • Recombinant bone morphogenetic protein heterodimers
    Patent number: 5866364
    Abstract: The present invention relates to a methods for producing recombinant heterodimeric BMP proteins useful in the field of treating bone defects, healing bone injury and in wound healing in general. The invention also relates to the recombinant heterodimers and compositions containing them.
    Type: Grant
    Filed: November 27, 1992
    Date of Patent: February 2, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: David Israel, Neil M. Wolfman
  • Bone morphogenetic protein (BMP)--6
    Patent number: 5849880
    Abstract: Purified bone morphogenetic protein (BMP)-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 15, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Elizabeth A. Wang, Vicki A. Rosen, Anthony J. Celeste
  • DNA encoding and methods for producing BMP-8 proteins
    Patent number: 5688678
    Abstract: Purified cartilage and/or bone inductive proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: November 26, 1991
    Date of Patent: November 18, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Rodney M. Hewick, Jack H. Wang, John M. Wozney, Anthony J. Celeste
  • Bone morphogenetic protein-9 compositions
    Patent number: 5661007
    Abstract: Purified bone morphogenetic protein-9 (BMP-9) proteins and processes for producing them are disclosed, The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: August 26, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Anthony J. Celeste
  • Bone morphogenic protein-5(BMP-5) and DNA encoding same
    Patent number: 5635373
    Abstract: Purified BMP-5 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 3, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Vicki A. Rosen, Elizabeth A. Wang
  • Compositions comprising bone morphogenetic protein-2 (BMP-2)
    Patent number: 5631142
    Abstract: Purified BMP-2 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: September 7, 1993
    Date of Patent: May 20, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Elizabeth A. Wang, John M. Wozney, Vicki A. Rosen
  • BMP-2 products
    Patent number: 5618924
    Abstract: Purified BMP-2 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: April 8, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Elizabeth A. Wang, John M. Wozney, Vicki Rosen
  • Bone morphogenetic protein 5(BMP-5) compositions
    Patent number: 5543394
    Abstract: Purified BMP-5 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: September 7, 1993
    Date of Patent: August 6, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Vicki A. Rosen, Elizabeth A. Wang
  • BMP-6 proteins
    Patent number: 5459047
    Abstract: Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: October 17, 1995
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Elizabeth A. Wang, Vicki A. Rosen, Anthony J. Celeste