Patents Represented by Attorney, Agent or Law Firm Elliott Korsen
  • Antagonists of gonadotropin releasing hormone
    Patent number: 5985901
    Abstract: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
    Type: Grant
    Filed: May 22, 1998
    Date of Patent: November 16, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Mark Goulet, Feroze Ujjainwalla, Thomas F. Walsh, Matthew J. Wyvratt, Jr., Jonathan R. Young, Lin Chu
  • Antagonists of gonadotropin releasing hormone
    Patent number: 5985892
    Abstract: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: November 16, 1999
    Assignee: Merck & Co., Ltd.
    Inventors: Thomas F. Walsh, Mark T. Goulet, Feroze Ujjainwalla, Robert L. Bugianesi
  • Antagonists of gonadotropin releasing hormone
    Patent number: 5981550
    Abstract: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
    Type: Grant
    Filed: May 22, 1998
    Date of Patent: November 9, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Mark Goulet, Thomas F. Walsh, Feroze Ujjainwalla, Matthew J. Wyvratt, Jr., Jonathan R. Young, Lin Chu
  • Microbial transformation products with antifungal properties
    Patent number: 5972994
    Abstract: Biotransformation products of a fermentation with Streptomyces sp., (Merck Culture Collection MA7165) ATCC No. 55946 are potent antifungal agents. These products may be useful in the treatment of diseases caused by fungal pathogens such as Candida sp. and Cryptococcus neoformans.
    Type: Grant
    Filed: March 24, 1998
    Date of Patent: October 26, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Ali Shafiee, Guy H. Harris, Deborah L. Zink, Janet M. Sigmund, Mark J. Rosenbach, Suzanne Miller Mandala
  • Antifungal compositions
    Patent number: 5952300
    Abstract: The invention is a pharmaceutical composition for intravenous administration to a patient comprisinga) a pharmaceutically effective amount of a compound having the formula ##STR1## and the pharmaceutically acceptable salts thereof; b) a pharmaceutically acceptable amount of an excipient such as a bulking agent effective to form a lyophilized cake; andc) a pharmaceutically acceptable amount of acetate buffer effective to provide a pH of between about 4 and 7.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: September 14, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Maneesh J. Nerurkar, William A. Hunke, Michael J. Kaufman
  • Antifungal macrolides and their synthesis
    Patent number: 5948770
    Abstract: There are disclosed novel antifungal macrolides of the formula ##STR1## compositions containing said compounds, methods of using said compounds and a method for synthesizing the compounds.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: September 7, 1999
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Bruno Tse
  • Reaction vessel filter for combinatorial chemistry or biological use
    Patent number: 5945070
    Abstract: A filter tube for a reaction or other fluid vessel is disclosed which maintains the vessel under an inert gas atmosphere and maintains the integrity of the inert gas seal while performing filtered or unfiltered filling or filtered draining operations.
    Type: Grant
    Filed: October 21, 1997
    Date of Patent: August 31, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Gary S. Kath, Gregory W. King
  • Cyclohexapeptidyl propanolamine compounds
    Patent number: 5939384
    Abstract: Certain propanolamine compounds which have a cyclohexapeptidyl nucleus and which are found to have extremely active antibiotic activity with physical properties suitable for direct use in therapeutic compositions are described. A novel process for their preparation is also described.
    Type: Grant
    Filed: September 3, 1992
    Date of Patent: August 17, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Milton L. Hammond, Robert A. Zambias
  • Process for preparing certain aza cyclohexapeptides
    Patent number: 5936062
    Abstract: There is disclosed a novel process for preparing aza cyclohexapeptides of the formula ##STR1## where all variables are defined herein.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: August 10, 1999
    Assignee: Merck & Co., Inc.
    Inventors: William Leonard, Kevin M. Belyk
  • Process for preparing dibenzocycloheptene compounds
    Patent number: 5932767
    Abstract: Protriptyline can be prepared from 5-dihydrodibenzocycloheptatriene, by deprotonation, followed by reaction at low temperatures with 1,3-bromochloropropane to give the 5-(chloropropyl)-dibenzocycloheptatriene, which is reacted with methylamine in a displacement reaction to give the protriptyline product.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: August 3, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Robert S. Hoerrner, Joseph Auerbach, John Carolan
  • 1-?4-hydroxy-5-aminoethyloxy-N.sup.2 -(10,12-dimethyl-1-oxotetradecyl)ornithine!-5-(3-hydroxyglutamine)-6-(3- hydroxyproline)echinocandin B, other aminoalkyl derivatives and salts thereof
    Patent number: 5914313
    Abstract: A compound having the formula ##STR1## in which R.sub.1 is an aminoalkyl group and ##STR2## is an acyl group and salts thereof having high antibiotic activity and being substantially free of lytic activity are described.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: June 22, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Frances Aileen Bouffard, James F. Dropinski
  • Transformation of Candida albicans by electroporation
    Patent number: 5908753
    Abstract: There is disclosed a procedure for DNA-mediated transformation of Candida albicans by electroporation utilizing lithium acetate and dithiothreitol to weaken the cell wall structure and optimize the yield of transformants.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: June 1, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Rosemarie Kelly, Elizabeth A. Register, Myra B. Kurtz, John R. Thompson
  • Deflected septum seal access port
    Patent number: 5882601
    Abstract: An access port for a reaction or other fluid vessel which maintains the vessel under an inert gas atmosphere and maintains the integrity of the inert gas seal while performing filtered filling or draining operations is presented. The port uses a deflected septum sealing technique. The invention can be used for a number of laboratory and clinical operations on a variety of size and shape vessels. The combination of the appropriate vessel with this access port is very well suited for use in lab automation systems, such as automated solid phase chemical synthesis, biological screening, combinatorial chemistry and other areas where reaction chemistry is conducted.
    Type: Grant
    Filed: June 18, 1997
    Date of Patent: March 16, 1999
    Assignee: Merck & Co., Ltd.
    Inventors: Gary S. Kath, Lihu Yang, Gregory W. King
  • Transformation of saccharomyces cerevisiae by electroporation
    Patent number: 5879891
    Abstract: There is disclosed a procedure for DNA-mediated transformation of Saccharomyces cerevisiae by electroporation utilizing lithium acetate and dithiothreitol to weaken cell wall structure resulting in increased transformation efficiency.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: March 9, 1999
    Assignee: Merck & Co., Inc.
    Inventor: John R. Thompson
  • Amino acid conjugates of cyclohexapeptidyl amines
    Patent number: 5874403
    Abstract: Novel amino acid conjugates of cyclohexa-peptidyl amines having the formula ##STR1## and having antifungal and antiparasital properties are described. The compounds exhibit less acute toxicity than the free amines.
    Type: Grant
    Filed: October 15, 1992
    Date of Patent: February 23, 1999
    Assignee: Merck & Co., Inc.
    Inventor: Robert A. Zambias
  • Substituted imidazoles having cytokine inhibitory activity
    Patent number: 5859041
    Abstract: Compounds represented by formula I: ##STR1## are disclosed. .sup.AR represents an aromatic group containing 6-10 atoms; and ##STR2## represents a 4 to 10 membered non-aromatic heterocycle containing at least one N atom, and optionally containing 1-2 additional N atoms and 0-1 O or S atom. A pharmaceutical composition is also included. Methods of treating cancer and cytokine mediated diseases are also included.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: January 12, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Nigel J. Liverton, David A. Claremon, John W. Butcher, Mark T. Bilodeau
  • Antifungal cyclohexapeptides
    Patent number: 5854213
    Abstract: The present invention is directed to novel carba cyclohexapeptide compounds of the formula ##STR1## where all substituents are defined herein, which are useful as antifungal agents and for the treatment of Pneumocystis carinii infections. Compositions containing the compounds of the invention are also disclosed.
    Type: Grant
    Filed: June 6, 1997
    Date of Patent: December 29, 1998
    Assignee: Merck & Co., Inc.
    Inventor: Frances A. Bouffard
  • Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
    Patent number: 5854212
    Abstract: A compound of the formula ##STR1## is disclosed which is useful for the treatment of fungal infections and for the treatment of infections caused by Pneumocystis carinii.
    Type: Grant
    Filed: October 23, 1996
    Date of Patent: December 29, 1998
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Frances A. Bouffard, James F. Dropinski
  • Antagonists of gonadotropin releasing hormone
    Patent number: 5849764
    Abstract: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
    Type: Grant
    Filed: December 5, 1996
    Date of Patent: December 15, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Mark Goulet, Lin Chu, Thomas F. Walsh, Michael H. Fisher, Narindar N. Girotra, Matthew J. Wyvratt, Peter Lin, Wallace T. Ashton
  • Combined dispenser and cap
    Patent number: D405005
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: February 2, 1999
    Assignee: Merck & Co., Inc.
    Inventor: Arthur L. Lifshey