Patents Represented by Attorney Elmore, Craig & Vanstone, P.C.
  • Patent number: 7129221
    Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: October 31, 2006
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Yat Sun Or, Guoqiang Wang, Ly Tam Phan, Deqiang Niu, Yao-Ling Qiu, Nha Huu Vo, Jay Judson Farmer, Ying Hou
  • Patent number: 7064110
    Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Grant
    Filed: November 19, 2003
    Date of Patent: June 20, 2006
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Yat Sun Or, Wang Guoqiang, Ly Tam Phan, Deqiang Niu, Nha Huu Vo, Yao-Ling Qiu, Yanchun Wang, Marina Busuyek, Ying Hou, Yulin Peng, Heejin Kim, Tongzhu Liu, Jay Judson Farmer, Guoyou Xu
  • Patent number: 7022679
    Abstract: The present invention relates to processes and intermediates for the preparation of 6–11 bicyclic erythromycin derivatives.
    Type: Grant
    Filed: January 14, 2004
    Date of Patent: April 4, 2006
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Heejin Kim, Guoqiang Wang, Yat Sun Or, Zhe Wang
  • Patent number: 6979437
    Abstract: A method for treating a disorder of the central nervous system includes administering to the respiratory tract of a patient a drug which is delivered to the pulmonary system, for instance to the alveoli or the deep lung. The drug is administered at a dose which is at least about two-fold less than the dose required by oral administration. Particles that include the drug can be employed. Preferred particles have a tap density of less than about 0.4 g/cm3. In addition to the medicament, the particles can include other materials such as, for example, phospholipids, amino acids, combinations thereof and others.
    Type: Grant
    Filed: May 20, 2003
    Date of Patent: December 27, 2005
    Assignee: Advanced Inhalation Research, Inc.
    Inventors: Raymond T. Bartus, Dwaine F. Emerich
  • Patent number: 6977087
    Abstract: Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 ?m and 30 ?m. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear ?-hydroxy-acid polyester backbone having at least one amino acid group incorporated herein and at least on poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 ?m, can be used for enhanced delivery of a therapeutic or diagnostic agent to the alveolar region of the lung.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: December 20, 2005
    Assignees: Massachusetts Institute of Technology, The Penn State Research Foundation
    Inventors: David A. Edwards, Giovannia Caponetti, Jeffrey S. Hrkach, Noah Lotan, Justin Hanes, Abdell Aziz Ben-Jebria, Robert S. Langer
  • Patent number: 6956021
    Abstract: Spray-dried particles having improved protein stability are produced by spray-drying a mixture including a protein, a phospholipid and an organic-aqueous co-solvent. Spray-dried particles which include at least 1 weight % phospholipid, having a tap density of less than 0.4 g/cm3 can be prepared. The particles can be delivered to the pulmonary system of a patient.
    Type: Grant
    Filed: August 25, 1999
    Date of Patent: October 18, 2005
    Assignee: Advanced Inhalation Research, Inc.
    Inventors: David A. Edwards, Jeffrey S. Hrkach
  • Patent number: 6953782
    Abstract: The present invention discloses compounds of formulae I, II, III or IV or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: October 11, 2005
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Ly Tam Phan, Yat Sun Or, Jay Judson Farmer
  • Patent number: 6921528
    Abstract: A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. Another method of delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single breath, includes administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of at least 0.4 g/cm3 and deliver at least about 10 milligrams of the bioactive agent. The receptacle can have a volume of at least 0.37 cm3.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: July 26, 2005
    Assignee: Advanced Inhalation Research, Inc.
    Inventors: David A. Edwards, Richard P. Batvcky, Lloyd Johnston
  • Patent number: 6901904
    Abstract: The invention provides a toroidal intersecting vane machine incorporating intersecting rotors to form primary and secondary chambers whose porting configurations minimize friction and maximize efficiency. Specifically, it is an object of the invention to provide a toroidal intersecting vane machine that greatly reduces the frictional losses through intersecting surfaces without the need for external gearing by modifying the width of one or both tracks at the point of intermeshing. The inventions described herein relate to these improvements.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: June 7, 2005
    Assignee: Mechanology, LLC
    Inventors: Jedd N. Martin, Stephen M. Chomyszak
  • Patent number: D515613
    Type: Grant
    Filed: January 13, 2005
    Date of Patent: February 21, 2006
    Inventors: Joseph T. Holmes, Shawn Michael Daley