Patents Represented by Attorney EMD Serono Research Institute

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  • Tricyclic spiro derivatives as CRTH2 modulators
    Patent number: 8236963
    Abstract: The present invention is related to the use of spiro derivatives of Formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is related to the use of spiro derivatives for the modulation of CRTH2 activity.
    Type: Grant
    Filed: May 23, 2006
    Date of Patent: August 7, 2012
    Assignee: Merck Serono SA
    Inventors: Matthias Schwarz, Eric Sebille, Christophe Cleva, Cedric Merlot, Dennis Church, Patrick Page, Jacqueline A. Macritchie, John Frederick Atherall, Stefano Crosignani, Doris Pupowicz
  • Heteroaryl-substituted arylaminopyridine derivatives as MEK inhibitors
    Patent number: 8076486
    Abstract: The invention provides novel heteroaryl-substituted arylaminopyridine derivative MEK inhibitors of Formula (Ia) Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: December 13, 2011
    Assignee: Merck Serono S.A.
    Inventors: Andreas Goutopoulos, Benny C. Askew, Jr., Xiaoling Chen, Srinivasa Karra, Henry Yu