Abstract: The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative conditions mediated by CXCR4 receptors or for the treatment of viral infections. The compounds provided interfere with the binding of SDF1 to the receptor. These compounds are particularly useful for treating or reducing the severity of hyperproliferative diseases by inhibiting metastasis, or for reducing entry of HIV in to a cell while not reducing the capacity of the stem cells to proliferate. The compounds may be useful for long term treatment regimes.
Type:
Grant
Filed:
July 11, 2007
Date of Patent:
December 20, 2011
Assignee:
Emory University
Inventors:
Dennis C. Liotta, James P. Snyder, Weiqiang Zhan
Abstract: A cardioplegia catheter system for delivery of a cardioplegia solution, comprising a cardioplegia catheter comprising an elongate tubular catheter body that defines a continuous central lumen and a flange that is connected to and extends therefrom an exterior surface of the catheter body, the flange defining a plurality of suture openings that extend therethrough the flange from a top surface to a bottom surface thereof. The cardioplegia system further comprising at least one stay suture and at least one suture capture stylet having a distal portion that is adapted to extend through one suture opening of the plurality of suture openings in the flange of the catheter body, wherein the distal portion of the rod has a shape that is adapted for slideably grasping a portion of the at least one stay suture.