Patents Represented by Attorney, Agent or Law Firm Eric P. Mirabel
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Patent number: 8349552Abstract: A new blood unit cooling system was designed to cool blood rapidly to about 22° C. and maintain it at about that temperature, even in ambient temperature extremes, for several hours. The system incorporating a preferred eutectic solution including 98% 1-dodecanol, 1.5% myristyl alcohol and 0.5% 1-decanol (having, a melting point of about 23° C.) contained in a sealed flexible polymer layer, was used to cool whole blood-filled bags. The preferred design uses inner and outer containers, each made of transparent polyethylene sheets, where the inner compartments are filled with the solution and sealed, and then placed into each compartment in an outer container, wherein two compartments in the outer container are separated by a flattened and sealed portion of the polyethylene.Type: GrantFiled: March 27, 2012Date of Patent: January 8, 2013Assignee: TCP Reliable, Inc.Inventors: Klaus H. Haarmann, Anthony Alleva, Thomas-Laurent Bingas
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Patent number: 8316662Abstract: The present invention is an apparatus, method and system to thermally package an item having at least one container (100) substantially filled with an alcohol, wherein said alcohol undergoes a phase change.Type: GrantFiled: February 21, 2012Date of Patent: November 27, 2012Assignee: TCP Reliable, Inc.Inventor: Benjamin Romero
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Patent number: 8263338Abstract: The invention encompasses methods for enriching for and identifying a polymorphism within a nucleic acid sample either by separating a subset of a nucleic acid sample or by selectively replicating a subset of a nucleic acid sample such that the polymorphism is contained within a nucleic acid population with reduced complexity, and then identifying the polymorphism within the enriched nucleic acid sample.Type: GrantFiled: April 11, 2007Date of Patent: September 11, 2012Assignee: Catalyst Assets LLCInventor: Joseph A. Sorge
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Patent number: 8192924Abstract: A new blood unit cooling system was designed to cool blood rapidly to about 22° C. and maintain it at about that temperature, even in ambient temperature extremes, for several hours. The system incorporating a preferred eutectic solution including 98% 1-dodecanol, 1.5% myristyl alcohol and 0.5% 1-decanol (having a melting point of about 23° C.) contained in a sealed flexible polymer layer, was used to cool whole blood-filled bags. The preferred design used double-layered transparent polyethylene, with two sealed compartments filled with the solution, separated by a flattened and sealed portion between them. One of the two sealed compartments contacts one side of the blood bag and the other compartment is folded over to contact the other side of the blood bag. The transparent compartments allows an operator to verify at any time whether the solution is in a solid state, and the flexibility of the compartments eases the proper positioning of them around a blood bag.Type: GrantFiled: October 17, 2011Date of Patent: June 5, 2012Assignee: TCP Reliable, Inc.Inventors: Maurice Barakat, Louis Thibault, Klaus H. Haarmann, Annie Beauséjour, Anthony Alleva, Mario Tremblay, Serghe Lapointe
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Patent number: 8105577Abstract: Sunflower lecithin or sunflower lecithin with oleic acid stimulate the growth and lactic acid producing activity of Lactobacillus and Bifidobacterium species of probiotic bacteria, and replace polysorbate 80 for those products. They can be used in naturally occurring form, or, where they are to be combined with probiotics in a carrier, they can preferably be adsorbed to carriers to yield a stable powdered form of these naturally oily compounds. They can be sold as combined prebiotic/probiotic formulations in the same carrier, or sold as separate dietary supplements, e.g., in capsule or tablet form, to be used with the probiotic formulation as desired.Type: GrantFiled: July 19, 2011Date of Patent: January 31, 2012Assignee: Master Supplements, Inc.Inventors: Randolph S. Porubcan, Sonja Lea Yonak
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Patent number: 8105576Abstract: Sunflower lecithin or sunflower lecithin with oleic acid stimulate the growth and lactic acid producing activity of Lactobacillus and Bifidobacterium species of probiotic bacteria, and replace polysorbate 80 for those products. They can be used in naturally occurring form, or, where they are to be combined with probiotics in a carrier, they can preferably be adsorbed to carriers to yield a stable powdered form of these naturally oily compounds. They can be sold as combined prebiotic/probiotic formulations in the same carrier, or sold as separate dietary supplements, e.g., in capsule or tablet form, to be used with the probiotic formulation as desired.Type: GrantFiled: July 11, 2011Date of Patent: January 31, 2012Assignee: Master Supplements, Inc.Inventors: Randolph S. Porubcan, Sonja Lea Yonak
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Patent number: 8066640Abstract: The Cellular GPRS system includes a cellular-based Glucometer (CBG) for blood glucose monitoring, a pedometer for exertion measurement, combined with user-entered dietary or other diabetes-relevant information. Data from all inputs is transmitted over a cellular network, using a GPRS or other wireless link. The data is preferably stored in the device prior to being transmitted wirelessly over the cellular airway to a central computer server. The remote computer server will evaluate the data received and respond with a data packet (making recommendations on further glucose measurement, exercise, diet, insulin requirements or other).Type: GrantFiled: April 21, 2009Date of Patent: November 29, 2011Assignee: EOS Health, Inc.Inventor: Kimon Angelides
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Patent number: 8066986Abstract: Disclosed are formulations for enhancing the in vivo colonization of probiotic microorganisms that include digestive enzymes and probiotic microorganisms, and polysorbate surfactants. The enzymes include lactogenic enzyme formulations that promote growth of Lactobacillus probiotics, bifidogenic enzyme formulations that promote growth of Bifidobacterium probiotics and combination formulations that benefit both types of probiotics. It has been discovered that certain polysorbate surfactants, including polysorbate-60 and polysorbate-80, further promote probiotic microorganism growth, when used with the enzyme formulations. The formulations are preferably compounded as dry powders, to avoid water reaction with the enzymes in blended formulations. Such formulations can be contained in capsules, tablets, packets or bottles and administered orally, either sequentially or in one combined formulation.Type: GrantFiled: January 30, 2008Date of Patent: November 29, 2011Assignee: Master Supplements, Inc.Inventor: Randolph S. Porubcan
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Patent number: 7935307Abstract: A disposable glucometer is disclosed which includes a testing region for receiving a test strip and electronic components to perform blood glucose monitoring, a cell phone interface for relaying test results to a monitoring station or server (which can be through a Bluetooth radio), and a multi-strip test strip holder. The glucometer includes a mechanism to automatically load test strips, one at a time, from the multi-strip test strip holder into the testing region, and a mechanism to eject the strip from the testing region after the test is complete. The test strip holder is preferably encased in a transparent material or otherwise includes a visual indicator so that the number of strips remaining strips and available for testing can be determined. In one embodiment, the entire unit is disposable, and is discarded when all of the strips have been used. In another embodiment, the test strip holder portion of the unit is removed and replaced with a new test strip holder which is loaded with test strips.Type: GrantFiled: May 30, 2008Date of Patent: May 3, 2011Assignee: EOS Health, DVC.Inventor: Kimon Angelides
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Patent number: 7905005Abstract: A method of joining panels of foam materials such that edges are compressed into panel surfaces to provide a secured and effectively sealed structure is disclosed. Panels in an orthogonal relationship to each other, which are made of foam (or other materials not intended to be load bearing) can be joined by compressing the outer side of one of the panels into the edge surface of an adjoining panel. This is done using two plates, one resting on the outer side of the first panel, and one inserted into the side of the second panel, where the plates are connected by a bolt, screw or wire under tension.Type: GrantFiled: February 2, 2007Date of Patent: March 15, 2011Assignee: TCP Reliable, Inc.Inventor: Michael Goncharko
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Patent number: 7849708Abstract: Insulated containers which conform relatively closely in size to the payload size, which contain a payload and phase change material and/or a refrigerated gel are all placed in a larger insulated shipping container, which may house additional phase change material and/or refrigerant. The combined insulating effect of the inner and outer containers allows minimizing the use of phase change material inside the inner container for the payload itself, and the presence of the phase material, together with the use of frozen gels inside the outer container, provides for only a small difference in temperature between the interior of the inner container and the interior of the outer container. The inner containers can be less insulated and lower cost, and the outer containers can be recycled.Type: GrantFiled: February 20, 2007Date of Patent: December 14, 2010Assignee: TCP Reliable, Inc.Inventors: Michael Goncharko, Maurice Barakat
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Patent number: 7635565Abstract: This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.Type: GrantFiled: May 1, 2008Date of Patent: December 22, 2009Assignee: BioArray Solutions Ltd.Inventors: Ghazala Hashmi, Michael Seul, Joachim Messing
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Patent number: 7625765Abstract: The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self supporting organic (polymeric) films and organic (polymeric)-microparticle composite films of tailored composition and morphology; the present invention further relates to the incorporation of said assemblies into other structures. The present invention also relates to the application of such functional assemblies in materials science and biology. Additional areas of application include sensors, catalysts, membranes, micro-reactors, smart materials. Miniaturized format for generation of multifunctional thin films. Provides a simple set-up to synthesize thin films of tailored composition and morphology.Type: GrantFiled: October 19, 2005Date of Patent: December 1, 2009Assignee: Bio Array Solutions Ltd.Inventors: Sukanta Banerjee, Kairali Podual, Michael Seul
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Patent number: 7618792Abstract: Disclosed are methods for detecting antibody in a sample, where the antibody targets an antigen expressed by red blood cells or red blood cell ghosts. Rather than detecting the binding events between a particular antigen antibody pair (as in traditional agglutination based assays) the methods herein allow for multiplexed detection of clinically important allo-immune antibodies to blood group antigens. Specifically the method involves generating fluorescently encoded red blood cells or red blood cell ghosts with known antigen presentation and using them to detect the presence of antibody in serum/plasma with a fluorescent sandwich type immunoassay. The assay results can be read using flow cytometric or fluorescent microscope based imaging techniques.Type: GrantFiled: January 6, 2006Date of Patent: November 17, 2009Assignee: BioArray Solutions Ltd.Inventor: Sukanta Banerjee
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Patent number: 7615345Abstract: A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations.Type: GrantFiled: May 16, 2006Date of Patent: November 10, 2009Assignee: Bio Array Solutions Ltd.Inventor: Michael Seul
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Patent number: 7613573Abstract: Disclosed is a registry for candidate transfusion donors, which invokes an inventory management policy to create and actively manage lists of candidate donors in order to minimize imbalances between demand and supply across multiple regions and across multiple categories of donors and recipients. Together with a genotyping laboratory, the registry does targeted recruitment of prospective donors who are typed for a set of genetic markers relating to clinically relevant antigens including mutations of Human Erythrocyte Antigens (HEA), genetic variants of Rh, and possibly additional antigens such as HLA and HPA. The registry monitors incoming demand for transfusion antigen genotypes, preferably stratify the demand into a set of categories representing stable subpopulations, and will apply strategies, disclosed herein, to tune the composition of candidate donor lists to match the demand, thereby avoiding excess, and unnecessary, typing of candidate donors.Type: GrantFiled: April 27, 2006Date of Patent: November 3, 2009Inventors: Yi Zhang, Michael Seul
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Patent number: 7612193Abstract: Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes—and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.Type: GrantFiled: September 9, 2008Date of Patent: November 3, 2009Assignee: BioArray Solutions Ltd.Inventors: Ghazala Hashmi, Michael Seul, Marion E. Reid, Michael Pierce
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Patent number: 7604718Abstract: A dynamically configurable electrode includes a first planar electrode and a planar array of pixels in a different plane, wherein a polarizable liquid medium (including electrolyte solutions) is to reside in the gap between electrodes. The pixels are individually addressable by a time-varying voltage, and adjacent pixels receive, at any instant in time, either the same voltage waveform or a different voltage waveform. Adjacent pixels receiving different voltage waveforms generate corresponding movement of dipolar entities, including dipolar particles, ions, or dipolar molecules in the polarizable liquid medium between the electrodes, which can in turn generate fluid flow and movement of particles suspended in the fluid along the planar array surface.Type: GrantFiled: February 14, 2004Date of Patent: October 20, 2009Assignee: BioArray Solutions Ltd.Inventors: Yi Zhang, Michael Seul
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Patent number: 7595279Abstract: A polyelectrolyte having multiple exposed functional groups, each such group being capable of covalently bonding to a molecule, is immobilized on a surface for the purpose of bonding to a biomolecule. The biomolecule can be, for example, a nucleic acid, e.g., an amine functionalized oligonucleotide. The polyelectrolyte can include, e.g., BSA (Bovine Serum Albumin) which is bound to a functionalized surface using a covalent immobilization strategy, e.g., reaction with the surface of a tosyl-activated microparticle. Following such reaction, exposed reactive functional groups on the protein, such as amine, carboxyl, thiol, hydroxyl groups can further be utilized to covalently couple the oligonucleotide of interest using suitable chemistry.Type: GrantFiled: September 22, 2004Date of Patent: September 29, 2009Assignee: BioArray Solutions Ltd.Inventors: Xinwen Wang, Sukanta Banerjee
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Patent number: 7582488Abstract: Disclosed are gel-coated beads (including Hydrogel™-coated beads), which are capable of adsorbing, or absorbing, proteins and other biomolecules onto or into the gel coating. The gel-coated beads with absorbed or adsorbed biomolecules are suitable for use in an assays, purification or other purposes. The beads have a core made from any of a number of materials, including latex, coated with the gel shell. The biomolecules can be retained within the gel, following adsorption, by covalent attachment, or, by selection of conditions of ambient pH and/or ionic strength such that they are retained without further reaction. Therefore, adsorbed proteins would retain the ability to bind to their respective ligands.Type: GrantFiled: October 26, 2004Date of Patent: September 1, 2009Assignee: Bio Array Solutions Ltd.Inventors: Sukanta Banerjee, Enqing Tan