Patents Represented by Attorney Eric S. Dicker
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Patent number: 5827506Abstract: Apparatus for simulating skin tanning comprises a receptacle containing a fluid comprising dihydroxyacetone, a receptacle containing a fluid comprising an amino acid, and dispensing means for simultaneously or sequentially providing desired amounts of dihydroxyacetone and amino acid.Type: GrantFiled: November 13, 1995Date of Patent: October 27, 1998Assignee: Schering-Plough HealthCare Products, Inc.Inventors: James E. McShane, Carl Kaplan, Thomas A. Meyer
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Patent number: 5740792Abstract: A powder dispenser includes a powder housing for holding a supply of powdered material to be dispensed, the powder housing including an inhalation conduit provided displaced relation to the powdered material supply; a metering plate including a metered dose hole for holding a metered amount of the powdered material, and positioned below the powdered material supply, the metering plate and the powder housing being relatively rotatable with respect to each other about a common central axis; a counter providing a visual count of the number of doses of the powdered material that have been dispensed or remain to be dispensed in response to the relative rotation, the counter including counter rings providing the visual count, the counter rings being rotatable about the common central axis and having indicia thereon which display the visual count, and an actuating mechanism rotatable about the central axis for incrementally rotating the counter rings in response to the relative rotation; a nozzle for breaking up aggType: GrantFiled: June 1, 1995Date of Patent: April 21, 1998Assignee: Schering CorporationInventors: Charles R. Ashley, Charles M. Huck, Henry R. Sochon, Ken Wilkinson
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Patent number: 5687710Abstract: A powder dispenser includes a powder housing for holding a supply of powdered material to be dispensed, the powder housing including an inhalation conduit provided displaced relation to the powdered material supply; a metering plate including a metered dose hole for holding a metered amount of the powdered material, and positioned below the powdered material supply, the metering plate and the powder housing being relatively rotatable with respect to each other about a common central axis; a counter providing a visual count of the number of doses of the powdered material that have been dispensed or remain to be dispensed in response to the relative rotation, the counter including counter rings providing the visual count, the counter rings being rotatable about the common central axis and having indicia thereon which display the visual count, and an actuating mechanism rotatable about the central axis for incrementally rotating the counter rings in response to the relative rotation; a nozzle for breaking up aggType: GrantFiled: June 1, 1995Date of Patent: November 18, 1997Assignee: Schering CorporationInventors: Thomas J. Ambrosio, Alan J. Bilanin, Andrew E. Kaufman, David J. Kenyon, Srinivas Manthena, Tsong-Toh Yang
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Patent number: 5688787Abstract: Novel compounds of the formula ##STR1## wherein A is --CH.dbd.CH--B; --C.tbd.C--B; --(CH.sub.2).sub.p --X--B, and X is a bone, --NH-- or --S(O).sub.0-2 --; optionally substituted heteroaryl or benzofused heteroaryl; --C(O)--B; or ##STR2## D is B'--(CH.sub.2).sub.m C(O)--, B'--(CH.sub.2).sub.q --, B'--(CH.sub.2).sub.e --Z--(CH.sub.2).sub.r, wherein Z is --O--, --C(O)--, phenylene, --NR.sub.8 -- or --S(O).sub.0-2 --, B'--(alkenylene)--; B'--(alkadienylene)--; B'--(CH.sub.2).sub.t --Z--(alkenylene), B'--(CH.sub.2).sub.f --V--(CH.sub.2).sub.g --, wherein V is cycloalkylene, B'--(CH.sub.2).sub.t --V--(alkenylene) or B'--(alkenylene)--V--(CH.sub.2).sub.t --, B'--(CH.sub.2).sub.a --Z--(CH.sub.2).sub.b --V--(CH.sub.2).sub.d --, T--(CH.sub.2).sub.s --, wherein T is cycloalkyl; naphthylmethyl or optionally substituted heteroarylmethyl;B is optionally substituted phenyl;B' is naphthyl, optionally substituted heteroaryl or optionally substituted phenyl;R is hydrogen, fluoro, alkyl, alkenyl, alkynyl, or B--(CH.sub.2).sub.Type: GrantFiled: January 19, 1996Date of Patent: November 18, 1997Assignee: Schering CorporationInventors: Duane A. Burnett, John W. Clader, Sundeep Dugar, Wayne Vaccaro
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Patent number: 5645822Abstract: Apparatus for simulating skin tanning comprises a receptacle containing a fluid comprising dihydroxyacetone, a receptacle containing a fluid comprising a secondary polyamine, and dispensing means for simultaneously or sequentially providing desired amounts of dihydroxyacetone and polyamine.Type: GrantFiled: June 6, 1995Date of Patent: July 8, 1997Assignee: Schering-Plough HealthCare Products, Inc.Inventors: Thomas A. Meyer, Michael E. Ando
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Patent number: 5633246Abstract: Sulfur-substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar.sup.1 is aryl, R.sup.10 -substituted aryl or heteroaryl;Ar.sup.2 is aryl or R.sup.4 -substituted aryl;Ar.sup.3 is aryl or R.sup.5 -substituted aryl;X and Y are --CH.sub.2 --, --CH(lower alkyl)-- or --C(dilower alkyl)--;R is --OR.sup.6, --O(CO)R.sup.6, --O(CO)OR.sup.9 or --O(CO)NR.sup.6 R.sup.7 ; R.sup.1 is hydrogen, lower alkyl or aryl; or R and R.sup.1 together are .dbd.O;q is 0 or 1; r is 0, 1 or 2; m and n are 0-5; provided that the sum of m, n and q is 1-5;R.sup.4 is selected from lower alkyl, --OR.sup.6, --O(CO)R.sup.6, --O(CO)OR.sup.9, --O(CH.sub.2).sub.1-5 OR.sup.6, --O(CO)NR.sup.6 R.sup.7, --NR.sup.6 R.sup.7, --NR.sup.6 (CO)R.sup.7, --NR.sup.6 (CO)OR.sup.9, --NR.sup.6 (CO)NR.sup.7 R.sup.8, --NR.sup.6 SO.sub.2 R.sup.9, --COOR.sup.6, --CONR.sup.6 R.sup.7, --COR.sup.6, --SO.sub.2 NR.sup.6 R.sup.7, S(O).sub.0-2 R.sup.9, --O(CH.sub.2).sub.1-10 --COOR.sup.6, --O(CH.Type: GrantFiled: June 5, 1995Date of Patent: May 27, 1997Assignee: Schering CorporationInventors: Brian A. McKittrick, Sundeep Dugar, Duane A. Burnett
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Patent number: 5627176Abstract: Substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar.sup.1 is R.sup.3 -substituted aryl;Ar.sup.2 is R.sup.4 -substituted aryl;Ar.sup.3 is R.sup.5 -substituted aryl;Y and Z are independently --CH.sub.2 --, --CH(lower alkyl)-- or --C(dilower alkyl)--;A is --O--, --S--, --S(O)-- or --S(O).sub.2 --;R.sup.1 is --OR.sup.6, --O(CO)R.sup.6, --O(CO)OR.sup.9 or --O(CO)NR.sup.6 R.sup.7 ; R.sup.2 is hydrogen, lower alkyl or aryl; or R.sup.1 and R.sub.2 together are .dbd.O;q is 1, 2 or 3; p is 0, 1,2, 3 or 4;R.sup.5 is 1-3 substitutes independently selected from --OR.sup.6, --O(CO)R.sup.6, --O(CO)OR.sup.9, --O(CH.sub.2).sub.1-5 OR.sup.9, --O(CO)NR.sup.6 R.sup.7, --NR.sup.6 R.sup.7, --NR.sup.6 (CO)R.sup.7, --NR.sup.6 (CO)OR.sup.9, --NR.sup.6 (CO)NR.sup.7 R.sup.8, --NR.sup.6 SO.sub.2 -lower alkyl, --NR.sup.6 SO.sub.2 -aryl, --CONR.sup.6 R.sup.7, --COR.sup.6, --SO.sub.2 NR.sup.6 R.sup.7, S(O).sub.0-2 -alkyl, S(O).sub.0-2 -aryl, --O(CH.sub.2).Type: GrantFiled: March 13, 1995Date of Patent: May 6, 1997Assignee: Schering CorporationInventors: Michael P. Kirkup, Sundeep Dugar
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Patent number: 5624920Abstract: Sulfur-substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar.sup.1 is aryl or R.sup.10 -substituted aryl;Ar.sup.2 is aryl or R.sup.4 -substituted aryl;Ar.sup.3 is aryl or R.sup.5 -substituted aryl;X and Y are --CH.sub.2 --, --CH(lower alkyl)-- or --C(dilower alkyl)--;R is --OR.sup.6, --O(CO)R.sup.6, --O(CO)OR.sup.9 or --O(CO)NR.sup.6 R.sup.7 ; R.sup.1 is hydrogen, lower alkyl or aryl; or R and R.sup.1 together are .dbd.O;q is 0 or 1; r is 0, 1 or 2; m and n are 0-5; provided that the sum of m, n and q is 1-5;R.sup.4 is selected from lower alkyl, --OR.sup.6, --O(CO)R.sup.6, --O(CO)OR.sup.9, --O(CH.sub.2).sub.1-5 OR.sup.6, --O(CO)NR.sup.6 R.sup.7, --NR.sup.6 R.sup.7, --NR.sup.6 (CO)R.sup.7, --NR.sup.6 (CO)OR.sup.9, --NR.sup.6 (CO)NR.sup.7 R.sup.8, --NR.sup.6 SO.sub.2 R.sup.9, --COOR.sup.6, --CONR.sup.6 R.sup.7, --COR.sup.6, --SO.sup.2 NR.sup.6 R.sup.7, S(O).sub.0-2 R.sup.9, --O(CH.sub.2).sub.1-10 --COOR.sup.6, --O(CH.sub.2).sub.Type: GrantFiled: November 18, 1994Date of Patent: April 29, 1997Assignee: Schering CorporationInventors: Brian A. McKittrick, Sundeep Dugar, Duane A. Burnett
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Patent number: 5607931Abstract: Amides of the formula ##STR1## wherein: R.sup.1 is A and R.sup.2 is B; R.sup.1 is B and R.sup.2 is A; or R.sup.1 and R.sup.2 are independently selected from the group B;A is phenyl, substituted phenyl, heteroaryl, or substituted heteroaryl;B is cycloalkyl, substituted cycloalkyl, heterocycloalkyl, or substituted heterocycloalkyl;R.sup.3 is an alkyl chain of 1 to 25 carbon atoms, branched or straight; an alkenyl chain of 2 to 25 carbon atoms, branched or straight; a substituted alkyl chain; a substituted alkenyl chain; an interrupted alkyl chain; an interrupted alkenyl chain; a substituted interrupted alkyl chain; or a substituted interrupted alkenyl chain;R.sup.4 is hydrogen, lower alkyl, phenyl, Q-substituted phenyl, heteroaryl or Q-substituted heteroaryl;R.sup.6 and R.sup.7 are both H, or R.sup.6 and R.sup.7 together represent .dbd.Type: GrantFiled: March 20, 1995Date of Patent: March 4, 1997Assignee: Schering CorporationInventor: Sundeep Dugar
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Patent number: 5593975Abstract: Adenosine A.sub.2 agonists of the formula ##STR1## wherein R is hydrogen, alkyl, cycloalkyl or phenylalkyl;R.sub.1 is selected from the group consisting ofa) optionally substituted phenyl or naphthyl;b) --(CH.sub.2).sub.m --Het wherein m is 0-3 and Het is a 5 or 6 membered heterocyclic aromatic or non-aromatic ring, optionally benzocondensed;c) cycloalkyl optionally containing unsaturations or alkenyl; and ##STR2## wherein n is 0-4; R.sub.2 is hydrogen, methyl or phenyl;R.sub.5 is hydrogen, alkyl, cycloalkyl, cycloalkenyl or phenylalkyl; or R.sub.2 and R.sub.5 form a 5 or 6-membered carbocyclic ring; or R.sub.5 is hydrogen and R.sub.2 and R.sub.4 form an oxo group or a corresponding acetalic derivative;R.sub.4 is OH, NH.sub.2, dialkylamino, halogen or cyano; andR.sub.3 is alkyl, cycloalkyl, phenyl or benzyl; provided that when R is different from hydrogen or when R is hydrogen and R.sub.3 is phenyl or benzyl, R.sub.Type: GrantFiled: January 30, 1995Date of Patent: January 14, 1997Assignee: Schering CorporationInventor: Gloria Cristalli
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Patent number: 5531703Abstract: An applicator 10 includes a barrel 12 for containing a semisolid medicinal, the barrel including a large diameter cylindrical section 16, a small diameter cylindrical section 18 and an annular sloped transition section 20 that connects the large diameter cylindrical section and the small diameter cylindrical section, the sections being coaxial with each other, the small diameter cylindrical section including an inner surface defining an internal cavity for containing the medicinal, a first end 30 with a first opening 32 and equiangularly spaced, axially aligned evacuation channels 28 in the inner surface for venting air out of the barrel when the internal cavity is filled with the medicinal, and the large diameter cylindrical section includes a second opposite end with a second opening 24; a rubber plunger 58 for pushing the medicinal through the first opening, the plunger being slidably positioned in sealing contact with the inner surface of the small diameter cylindrical section; a plunger rod 86 connectedType: GrantFiled: October 26, 1994Date of Patent: July 2, 1996Assignee: Schering-Plough HealthCare Products, Inc.Inventors: Gary M. Skwarek, Stephen J. Morfit
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Patent number: D366956Type: GrantFiled: December 21, 1994Date of Patent: February 13, 1996Assignee: Schering-Plough HealthCare Products, Inc.Inventor: Kenneth M. Gay
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Patent number: D367164Type: GrantFiled: May 12, 1994Date of Patent: February 20, 1996Assignee: Schering-Plough Healthcare Products, Inc.Inventors: Randall K. Fisher, Donald B. Thompson
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Patent number: D374612Type: GrantFiled: May 31, 1995Date of Patent: October 15, 1996Assignee: Schering-Plough Healthcare Products, Inc.Inventors: Thomas Uhl, Ronald S. Elowitz, Robert C. Maxwell
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Patent number: D374613Type: GrantFiled: May 31, 1995Date of Patent: October 15, 1996Assignee: Schering-Plough Healthcare Products, Inc.Inventors: Robert C. Maxwell, Ronald S. Elowitz, Thomas Uhl
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Patent number: D374614Type: GrantFiled: May 31, 1995Date of Patent: October 15, 1996Assignee: Schering-Plough Healthcare Products, Inc.Inventors: Thomas Uhl, Robert C. Maxwell, Ronald S. Elowitz
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Patent number: D375255Type: GrantFiled: May 31, 1995Date of Patent: November 5, 1996Assignee: Schering-Plough Healthcare Products, Inc.Inventors: Thomas Uhl, Ronald S. Elowitz, Robert C. Maxwell
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Patent number: D375455Type: GrantFiled: May 31, 1995Date of Patent: November 12, 1996Assignee: Schering-Plough Healthcare Products, Inc.Inventors: Thomas Uhl, Robert C. Maxwell, Ronald S. Elowitz
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Patent number: D376536Type: GrantFiled: May 31, 1995Date of Patent: December 17, 1996Assignee: Schering-Plough Healthcare Products, Inc.Inventors: Robert C. Maxwell, Thomas Uhl, Ronald S. Elowitz
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Patent number: D384881Type: GrantFiled: May 31, 1995Date of Patent: October 14, 1997Assignee: Schering-Plough HealthCare Products, Inc.Inventors: Thomas Uhl, Ronald S. Elowitz, Robert C. Maxwell