Patents Represented by Attorney Eric S. Dicker
  • Patent number: 5827506
    Abstract: Apparatus for simulating skin tanning comprises a receptacle containing a fluid comprising dihydroxyacetone, a receptacle containing a fluid comprising an amino acid, and dispensing means for simultaneously or sequentially providing desired amounts of dihydroxyacetone and amino acid.
    Type: Grant
    Filed: November 13, 1995
    Date of Patent: October 27, 1998
    Assignee: Schering-Plough HealthCare Products, Inc.
    Inventors: James E. McShane, Carl Kaplan, Thomas A. Meyer
  • Patent number: 5740792
    Abstract: A powder dispenser includes a powder housing for holding a supply of powdered material to be dispensed, the powder housing including an inhalation conduit provided displaced relation to the powdered material supply; a metering plate including a metered dose hole for holding a metered amount of the powdered material, and positioned below the powdered material supply, the metering plate and the powder housing being relatively rotatable with respect to each other about a common central axis; a counter providing a visual count of the number of doses of the powdered material that have been dispensed or remain to be dispensed in response to the relative rotation, the counter including counter rings providing the visual count, the counter rings being rotatable about the common central axis and having indicia thereon which display the visual count, and an actuating mechanism rotatable about the central axis for incrementally rotating the counter rings in response to the relative rotation; a nozzle for breaking up agg
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: April 21, 1998
    Assignee: Schering Corporation
    Inventors: Charles R. Ashley, Charles M. Huck, Henry R. Sochon, Ken Wilkinson
  • Patent number: 5687710
    Abstract: A powder dispenser includes a powder housing for holding a supply of powdered material to be dispensed, the powder housing including an inhalation conduit provided displaced relation to the powdered material supply; a metering plate including a metered dose hole for holding a metered amount of the powdered material, and positioned below the powdered material supply, the metering plate and the powder housing being relatively rotatable with respect to each other about a common central axis; a counter providing a visual count of the number of doses of the powdered material that have been dispensed or remain to be dispensed in response to the relative rotation, the counter including counter rings providing the visual count, the counter rings being rotatable about the common central axis and having indicia thereon which display the visual count, and an actuating mechanism rotatable about the central axis for incrementally rotating the counter rings in response to the relative rotation; a nozzle for breaking up agg
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: November 18, 1997
    Assignee: Schering Corporation
    Inventors: Thomas J. Ambrosio, Alan J. Bilanin, Andrew E. Kaufman, David J. Kenyon, Srinivas Manthena, Tsong-Toh Yang
  • Patent number: 5688787
    Abstract: Novel compounds of the formula ##STR1## wherein A is --CH.dbd.CH--B; --C.tbd.C--B; --(CH.sub.2).sub.p --X--B, and X is a bone, --NH-- or --S(O).sub.0-2 --; optionally substituted heteroaryl or benzofused heteroaryl; --C(O)--B; or ##STR2## D is B'--(CH.sub.2).sub.m C(O)--, B'--(CH.sub.2).sub.q --, B'--(CH.sub.2).sub.e --Z--(CH.sub.2).sub.r, wherein Z is --O--, --C(O)--, phenylene, --NR.sub.8 -- or --S(O).sub.0-2 --, B'--(alkenylene)--; B'--(alkadienylene)--; B'--(CH.sub.2).sub.t --Z--(alkenylene), B'--(CH.sub.2).sub.f --V--(CH.sub.2).sub.g --, wherein V is cycloalkylene, B'--(CH.sub.2).sub.t --V--(alkenylene) or B'--(alkenylene)--V--(CH.sub.2).sub.t --, B'--(CH.sub.2).sub.a --Z--(CH.sub.2).sub.b --V--(CH.sub.2).sub.d --, T--(CH.sub.2).sub.s --, wherein T is cycloalkyl; naphthylmethyl or optionally substituted heteroarylmethyl;B is optionally substituted phenyl;B' is naphthyl, optionally substituted heteroaryl or optionally substituted phenyl;R is hydrogen, fluoro, alkyl, alkenyl, alkynyl, or B--(CH.sub.2).sub.
    Type: Grant
    Filed: January 19, 1996
    Date of Patent: November 18, 1997
    Assignee: Schering Corporation
    Inventors: Duane A. Burnett, John W. Clader, Sundeep Dugar, Wayne Vaccaro
  • Patent number: 5645822
    Abstract: Apparatus for simulating skin tanning comprises a receptacle containing a fluid comprising dihydroxyacetone, a receptacle containing a fluid comprising a secondary polyamine, and dispensing means for simultaneously or sequentially providing desired amounts of dihydroxyacetone and polyamine.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 8, 1997
    Assignee: Schering-Plough HealthCare Products, Inc.
    Inventors: Thomas A. Meyer, Michael E. Ando
  • Patent number: 5633246
    Abstract: Sulfur-substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar.sup.1 is aryl, R.sup.10 -substituted aryl or heteroaryl;Ar.sup.2 is aryl or R.sup.4 -substituted aryl;Ar.sup.3 is aryl or R.sup.5 -substituted aryl;X and Y are --CH.sub.2 --, --CH(lower alkyl)-- or --C(dilower alkyl)--;R is --OR.sup.6, --O(CO)R.sup.6, --O(CO)OR.sup.9 or --O(CO)NR.sup.6 R.sup.7 ; R.sup.1 is hydrogen, lower alkyl or aryl; or R and R.sup.1 together are .dbd.O;q is 0 or 1; r is 0, 1 or 2; m and n are 0-5; provided that the sum of m, n and q is 1-5;R.sup.4 is selected from lower alkyl, --OR.sup.6, --O(CO)R.sup.6, --O(CO)OR.sup.9, --O(CH.sub.2).sub.1-5 OR.sup.6, --O(CO)NR.sup.6 R.sup.7, --NR.sup.6 R.sup.7, --NR.sup.6 (CO)R.sup.7, --NR.sup.6 (CO)OR.sup.9, --NR.sup.6 (CO)NR.sup.7 R.sup.8, --NR.sup.6 SO.sub.2 R.sup.9, --COOR.sup.6, --CONR.sup.6 R.sup.7, --COR.sup.6, --SO.sub.2 NR.sup.6 R.sup.7, S(O).sub.0-2 R.sup.9, --O(CH.sub.2).sub.1-10 --COOR.sup.6, --O(CH.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: May 27, 1997
    Assignee: Schering Corporation
    Inventors: Brian A. McKittrick, Sundeep Dugar, Duane A. Burnett
  • Patent number: 5627176
    Abstract: Substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar.sup.1 is R.sup.3 -substituted aryl;Ar.sup.2 is R.sup.4 -substituted aryl;Ar.sup.3 is R.sup.5 -substituted aryl;Y and Z are independently --CH.sub.2 --, --CH(lower alkyl)-- or --C(dilower alkyl)--;A is --O--, --S--, --S(O)-- or --S(O).sub.2 --;R.sup.1 is --OR.sup.6, --O(CO)R.sup.6, --O(CO)OR.sup.9 or --O(CO)NR.sup.6 R.sup.7 ; R.sup.2 is hydrogen, lower alkyl or aryl; or R.sup.1 and R.sub.2 together are .dbd.O;q is 1, 2 or 3; p is 0, 1,2, 3 or 4;R.sup.5 is 1-3 substitutes independently selected from --OR.sup.6, --O(CO)R.sup.6, --O(CO)OR.sup.9, --O(CH.sub.2).sub.1-5 OR.sup.9, --O(CO)NR.sup.6 R.sup.7, --NR.sup.6 R.sup.7, --NR.sup.6 (CO)R.sup.7, --NR.sup.6 (CO)OR.sup.9, --NR.sup.6 (CO)NR.sup.7 R.sup.8, --NR.sup.6 SO.sub.2 -lower alkyl, --NR.sup.6 SO.sub.2 -aryl, --CONR.sup.6 R.sup.7, --COR.sup.6, --SO.sub.2 NR.sup.6 R.sup.7, S(O).sub.0-2 -alkyl, S(O).sub.0-2 -aryl, --O(CH.sub.2).
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: May 6, 1997
    Assignee: Schering Corporation
    Inventors: Michael P. Kirkup, Sundeep Dugar
  • Patent number: 5624920
    Abstract: Sulfur-substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar.sup.1 is aryl or R.sup.10 -substituted aryl;Ar.sup.2 is aryl or R.sup.4 -substituted aryl;Ar.sup.3 is aryl or R.sup.5 -substituted aryl;X and Y are --CH.sub.2 --, --CH(lower alkyl)-- or --C(dilower alkyl)--;R is --OR.sup.6, --O(CO)R.sup.6, --O(CO)OR.sup.9 or --O(CO)NR.sup.6 R.sup.7 ; R.sup.1 is hydrogen, lower alkyl or aryl; or R and R.sup.1 together are .dbd.O;q is 0 or 1; r is 0, 1 or 2; m and n are 0-5; provided that the sum of m, n and q is 1-5;R.sup.4 is selected from lower alkyl, --OR.sup.6, --O(CO)R.sup.6, --O(CO)OR.sup.9, --O(CH.sub.2).sub.1-5 OR.sup.6, --O(CO)NR.sup.6 R.sup.7, --NR.sup.6 R.sup.7, --NR.sup.6 (CO)R.sup.7, --NR.sup.6 (CO)OR.sup.9, --NR.sup.6 (CO)NR.sup.7 R.sup.8, --NR.sup.6 SO.sub.2 R.sup.9, --COOR.sup.6, --CONR.sup.6 R.sup.7, --COR.sup.6, --SO.sup.2 NR.sup.6 R.sup.7, S(O).sub.0-2 R.sup.9, --O(CH.sub.2).sub.1-10 --COOR.sup.6, --O(CH.sub.2).sub.
    Type: Grant
    Filed: November 18, 1994
    Date of Patent: April 29, 1997
    Assignee: Schering Corporation
    Inventors: Brian A. McKittrick, Sundeep Dugar, Duane A. Burnett
  • Patent number: 5607931
    Abstract: Amides of the formula ##STR1## wherein: R.sup.1 is A and R.sup.2 is B; R.sup.1 is B and R.sup.2 is A; or R.sup.1 and R.sup.2 are independently selected from the group B;A is phenyl, substituted phenyl, heteroaryl, or substituted heteroaryl;B is cycloalkyl, substituted cycloalkyl, heterocycloalkyl, or substituted heterocycloalkyl;R.sup.3 is an alkyl chain of 1 to 25 carbon atoms, branched or straight; an alkenyl chain of 2 to 25 carbon atoms, branched or straight; a substituted alkyl chain; a substituted alkenyl chain; an interrupted alkyl chain; an interrupted alkenyl chain; a substituted interrupted alkyl chain; or a substituted interrupted alkenyl chain;R.sup.4 is hydrogen, lower alkyl, phenyl, Q-substituted phenyl, heteroaryl or Q-substituted heteroaryl;R.sup.6 and R.sup.7 are both H, or R.sup.6 and R.sup.7 together represent .dbd.
    Type: Grant
    Filed: March 20, 1995
    Date of Patent: March 4, 1997
    Assignee: Schering Corporation
    Inventor: Sundeep Dugar
  • Patent number: 5593975
    Abstract: Adenosine A.sub.2 agonists of the formula ##STR1## wherein R is hydrogen, alkyl, cycloalkyl or phenylalkyl;R.sub.1 is selected from the group consisting ofa) optionally substituted phenyl or naphthyl;b) --(CH.sub.2).sub.m --Het wherein m is 0-3 and Het is a 5 or 6 membered heterocyclic aromatic or non-aromatic ring, optionally benzocondensed;c) cycloalkyl optionally containing unsaturations or alkenyl; and ##STR2## wherein n is 0-4; R.sub.2 is hydrogen, methyl or phenyl;R.sub.5 is hydrogen, alkyl, cycloalkyl, cycloalkenyl or phenylalkyl; or R.sub.2 and R.sub.5 form a 5 or 6-membered carbocyclic ring; or R.sub.5 is hydrogen and R.sub.2 and R.sub.4 form an oxo group or a corresponding acetalic derivative;R.sub.4 is OH, NH.sub.2, dialkylamino, halogen or cyano; andR.sub.3 is alkyl, cycloalkyl, phenyl or benzyl; provided that when R is different from hydrogen or when R is hydrogen and R.sub.3 is phenyl or benzyl, R.sub.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: January 14, 1997
    Assignee: Schering Corporation
    Inventor: Gloria Cristalli
  • Patent number: 5531703
    Abstract: An applicator 10 includes a barrel 12 for containing a semisolid medicinal, the barrel including a large diameter cylindrical section 16, a small diameter cylindrical section 18 and an annular sloped transition section 20 that connects the large diameter cylindrical section and the small diameter cylindrical section, the sections being coaxial with each other, the small diameter cylindrical section including an inner surface defining an internal cavity for containing the medicinal, a first end 30 with a first opening 32 and equiangularly spaced, axially aligned evacuation channels 28 in the inner surface for venting air out of the barrel when the internal cavity is filled with the medicinal, and the large diameter cylindrical section includes a second opposite end with a second opening 24; a rubber plunger 58 for pushing the medicinal through the first opening, the plunger being slidably positioned in sealing contact with the inner surface of the small diameter cylindrical section; a plunger rod 86 connected
    Type: Grant
    Filed: October 26, 1994
    Date of Patent: July 2, 1996
    Assignee: Schering-Plough HealthCare Products, Inc.
    Inventors: Gary M. Skwarek, Stephen J. Morfit
  • Patent number: D366956
    Type: Grant
    Filed: December 21, 1994
    Date of Patent: February 13, 1996
    Assignee: Schering-Plough HealthCare Products, Inc.
    Inventor: Kenneth M. Gay
  • Patent number: D367164
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: February 20, 1996
    Assignee: Schering-Plough Healthcare Products, Inc.
    Inventors: Randall K. Fisher, Donald B. Thompson
  • Patent number: D374612
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: October 15, 1996
    Assignee: Schering-Plough Healthcare Products, Inc.
    Inventors: Thomas Uhl, Ronald S. Elowitz, Robert C. Maxwell
  • Patent number: D374613
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: October 15, 1996
    Assignee: Schering-Plough Healthcare Products, Inc.
    Inventors: Robert C. Maxwell, Ronald S. Elowitz, Thomas Uhl
  • Patent number: D374614
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: October 15, 1996
    Assignee: Schering-Plough Healthcare Products, Inc.
    Inventors: Thomas Uhl, Robert C. Maxwell, Ronald S. Elowitz
  • Patent number: D375255
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: November 5, 1996
    Assignee: Schering-Plough Healthcare Products, Inc.
    Inventors: Thomas Uhl, Ronald S. Elowitz, Robert C. Maxwell
  • Patent number: D375455
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: November 12, 1996
    Assignee: Schering-Plough Healthcare Products, Inc.
    Inventors: Thomas Uhl, Robert C. Maxwell, Ronald S. Elowitz
  • Patent number: D376536
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: December 17, 1996
    Assignee: Schering-Plough Healthcare Products, Inc.
    Inventors: Robert C. Maxwell, Thomas Uhl, Ronald S. Elowitz
  • Patent number: D384881
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: October 14, 1997
    Assignee: Schering-Plough HealthCare Products, Inc.
    Inventors: Thomas Uhl, Ronald S. Elowitz, Robert C. Maxwell