Abstract: The viscometer of the present invention comprises a chamber, and inside the chamber is secured a measuring tube and a falling piston. The piston has a lift plate secured to its top by means of a short small shaft. There are one or more lifting fingers, which operate through a defined distance large enough to raise the piston up and then drop back down to a base position thus leaving the piston free to fall by gravity to its lowermost position. However, the mechanical design is such that these fingers when lowered will not touch the actual piston itself. Mounted underneath the piston, when it is in its lowermost position, is a proximity switch that is used to sense when the piston is in its lowermost position. The time it takes to travel from its raised position to its lowermost position is a function of viscosity. The present invention combines the concept of a "falling member" with a compact bi-directional flow concept and an easily opened and cleaned measuring chamber.

Abstract: Disclosed is a two-point calibration procedure, that when used with a mathematical algorithm, improves the accuracy of electrolytic conductivity measurements by correcting for non-linear behavior of conductivity cells. Unlike purely mathematical means of correcting for non-linearity which may use second or higher order equations, this algorithm has the following advantages: it is based on an analysis of the physical phenomena which are responsible for non-linearity; it yields one unique solution, i.e., it uses an equation that has only one root; and it yields diagnostic information concerning the behavior of the cell.

Abstract: An extrusion system for providing a foamed material in which a material such as a polymer material is supplied to an extruder for movement through a rotating screw member. The material is placed in a molten state and a foaming agent, such as a supercritical fluid, is introduced into the extruder at a selected pressure so that a two-phase mixture of the molten material and the foaming agent is formed. The foaming agent is then diffused into and dissolved in the molten material to form a single-phase solution which is forwarded from a solution formation to a nucleation device. A thermodynamic instability is induced through a rapid pressure drop, e.g., higher than 0.9 GPa/s in the nucleation device to nucleate microcells in the solution. A further shaping device, e.g., a die, can be used to produce a foamed material of a desired shape.

Abstract: The lamellarin compounds disclosed herein have been found to be inhibitors of MDR, i.e., acquired multidrug resistance, which has become a major problem in the treatment of various cancers. The lamellarin compounds disclosed herein have also been found to be cytotoxic to MDR cells. MDR is believed to be associated with certain alterations in tumor cells, including an over-expression of a certain high molecular weight membrane glycoprotein and a decrease in the ability of the tumor cell to accumulate and retain chemotherapeutic agents. The present invention is thus directed to methods of treating MDR-type tumors with an effective anti-MDR amount (either inhibitory or cytotoxic) of one or more lamellarin compounds, which compounds have been found to be effective antitumoral agents against MDR cells.

Abstract: The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.

Abstract: A new substrate for the construction of solid internal contact ion-selective electrode comprising a conductive and porous carbon matrix is described. The well-defined (i.e., fixed) interfacial potential between the organic electroactive phase and the internal reference element, coupled with the electrode's very slow change from water activity at the internal reference element, supports the well-behaved and reproducible electrode operation. Solid contact sensors for two different ions were constructed, and their potentiometric behavior was compared with their symmetric counterparts. The potentiometric response was monitored over a period of one month with excellent results for drift, base line stability, response time, selectivity, and detection limit.

Abstract: Antineoplastic cyclolignan derivatives are of formula (I): ##STR1## in which Ar is a 3,4,5-trialkoxyphenyl or 4-hydroxy-3,5-dialkoxyphenyl; X is an oxygen, sulphur or nitrogen atom, a methine group .dbd.CH-- or an alkylmethine group .dbd.C(alkyl)--; Y is a hydrogen atom or an alkyl, alkenyl, (poly)haloalkyl, aryl, hydroxy, alkoxy, amino, monoalkylamino, dialkylamino, (poly)haloalkylamino, arylamino, acyl or acetamido group, or the group Y is absent; Z is an alkyl, hydroxyalkyl, acyl, carboxy, alkoxycarbonyl or aryloxycarbonyl group; and the dotted lines indicate one double bond located at position .DELTA..sup.7-8 or .DELTA..sup.8-8'.

Abstract: Dehydrodidemnin B with useful biological activity has formula (1). It can be isolated from natural sources or synthesized, and it forms active derivatives.

Abstract: An antimalarial drug combination for prophylactic treatment or curative treatment of malaria comprises a first component which is a fenozan, that is a cis-fused cyclopenteno-1,2,4-trioxane, and a second component which is another antimalarial drug.

Abstract: The present invention is directed to a unique golf accessory, which in its most basic form comprises three fundamental parts; (a) a golf club/cleat brush; (b) a recoilable wire or tape and housing therefor; and (c) means for attaching the brush to the recoilable wire or tape. In preferred embodiments, the recoilable tape or wire includes measurement indications thereon, i.e., the tape or wire is marked in feet and inches (or meters and millimeters) to allow golfers to accurately determine putting distances. In addition, the housing for the recoilable tape or wire preferably includes a member suitable for attachment to a golf bag or the clothing of the golfer.

Abstract: A packaging component having an inflatable peripheral portion and an interior portion having one or more non-inflatable regions which are shaped to conform to one or more portions of an end or a side of a product so that, when the component is inflated, the component fits firmly and snugly against an end or side of the product. A plurality of such components can be integrally formed in a selected pattern adjacent one another to fit firmly and snugly against the ends or sides of a plurality of products which are corresponding positioned adjacent one another. A pair of such components can also be hingedly connected in an integral fashion so that, when inflated, they can be folded together to enclose a product therebetween.

Abstract: Halichondrin derivatives, isolatable from a marine sponge of the Lissodendoryx Sp., have cytotoxic preparations and are of the formula: ##STR1## wherein R.sup.1 and R.sup.

Abstract: Antineoplastic cyclolignan derivatives are of formula (I): ##STR1## in which Ar is a 3,4,5-trialkoxyphenyl or 4-hydroxy-3,5-dialkoxyphenyl; X is an oxygen, sulphur or nitrogen atom, a methine group .dbd.CH-- or an alkylmethine group .dbd.C(alkyl)--; Y is a hydrogen atom or an alkyl, alkenyl, (poly)haloalkyl, aryl, hydroxy, alkoxy, amino, monoalkylamino, dialkylamino, (poly)haloalkylamino, arylamino, acyl or acetamido group, or the group Y is absent; Z is an alkyl, hydroxyalkyl, acyl, carboxy, alkoxycarbonyl or aryloxycarbonyl group; and the dotted lines indicate one double bond located at position .DELTA..sup.7-8 or .DELTA..sup.8-8'.