Abstract: Novel cephalosporin and penicillin antibiotic derivatives.

Abstract: A hinged box which has two hinges protruding from the back of the box, each hinge member composed of five ball elements which are interlocked. Two balls of each group of the five elements have grooves extending across opposite faces of the ball members, at least halfway but not entirely across, which provide pockets for the three other ball members whereby the five ball members are locked securely in a rotatable position to form a hinge. Each of the two parts of the box has at the back two ball elements on one side of the box and three at the other side of the back. A further improvement in the hinged box comprises longitudinal cylindrical bar-like members protruding from the back of each section of the box and resting in grooves on the other section of the box. This construction adds strength and stiffness to the hinge without impairing the smooth action of the hinge when opening and closing the lid on the box.

Abstract: The inventive method comprises administering a morphanthridine to an animal to effect the lowering of inflammation. Representative of the compounds that can be used in the method are trans-5-acetyl-2-bromo-5,6-dihydro-11-(3-dimethylaminopropylidene)-morphan thridine and trans-2-bromo-11-(3-dimethylaminopropylidene)-5,6-dihydro-5-propionylmorph anthridine.

Abstract: Novel substituted(4-oxo-1-pyridinyl)acetylamino-penicillin and cephalosporin derivatives are prepared which are useful antibacterial agents.

Abstract: The method comprises administering to an animal an amount of substituted-1-oxo-1H-2-benzopyran-3-carboxylic acid effective to inhibit antigen-antibody reaction in said animal. Representative of the compounds that can be used in the method is sodium 1-oxo-1H-2-benzopyran-3-carboxylate.

Abstract: Compounds having the general formula: ##SPC1##Wherein R.sup.1 and R.sup.2 represent hydrogen, halogen, lower alkyl, lower alkoxy, or nitro, and wherein R.sup.1 and R.sup.2 may be the same or different. R.sup.3 may be hydrogen or lower alkyl, and X and Y may be one or two. They have been found to be useful sedative type depressants of the central nervous system.Most of the compounds having the general formula indicated above are new but others such as 2,3-dihydrospiro[naphthalene-1(4H),3'-piperidine]-2',4,6'-trione which has useful sedative properties have been reported in the literature.

Abstract: Novel process for the preparation of compounds of the following general structure which are useful as antidepressant and antiparkinson agents: ##SPC1##Wherein R represents hydrogen, hydroxy, halogen, trifluoromethyl, straight or branched lower alkyl of from 1 to 6 carbon atoms or straight or branched lower alkoxy of from 1 to 6 carbon atoms; R.sub.1 represents hydrogen, lower alkyl of from 1 to 6 carbon atoms, phenyl or benzyl; n is an integer of from 1 to 3; m is an integer of 1 or 2; and individual optical and geometric isomers and pharmaceutically acceptable acid addition salts thereof.

Abstract: Compounds useful as antiviral agents are those of the formula ##SPC1##Wherein each R.sup.1 is hydrogen or methyl; each n is an integer of 2 to 4; each of R.sup.2 and R.sup.3 is alkyl of 3 to 5 carbon atoms or alkenyl of 3 to 5 carbon atoms; or a pharmaceutically acceptable acid addition salt of said base. Pharmaceutical compositions are formed from these compounds with pharmaceutically acceptable carriers.

Abstract: Novel 2,7-bis-basic derivatives of fluorene, 9-fluorenol and 9-fluorenone, their preparation and use for the prevention and inhibition of virus infections are disclosed.

Abstract: A spill of liquid elemental mercury is cleaned up by being absorbed into a composition containing a granular metal, a metal powder and a non-hydroscopic solid acid.

Abstract: Water-insoluble therapeutic agents having a tertiary nitrogen capable of being protonated are stabilized and solubilized via the formation of water-soluble lipophilic liquid fatty acid salts.

Abstract: Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula ##SPC1##Wherein R represents hydrogen or hydroxy; R.sup.1 represents hydrogen; or R and R.sup.1 taken together form a second bond between the carbon atoms bearing R and R.sup.1 ; n is a positive whole integer of from 1 to 3; Z represents thienyl, phenyl, or substituted phenyl wherein the substituents on the substituted phenyl may be attached at the ortho, meta, or para positions of the phenyl ring and are selected from halogen, a straight or branched lower alkyl chain of from 1 to 4 carbon atoms, a lower alkoxy group of from 1 to 4 carbon atoms, di(lower)alkylamino, or a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino, or N-(lower)alkylpiperazino. Pharmaceutically acceptable acid addition salts and individual optical isomers of compounds of the above formula are also included as a part of this invention.

Abstract: Novel compounds useful as diuretic agents and anticoagulants are represented by the following formula ##SPC1##Wherein m is a positive whole integer of from 1 to 3; n is a positive whole integer of from 3 to 7; R and R.sup.1 may be the same or different and represent hydrogen, a straight or branched lower alkyl chain of from 1 to 4 carbon atoms, halogen, trifluorometyl, trifluoromethylthio, trifluoromethoxy, phenyl, phenoxy, or lower alkoxy of from 1 to 4 carbon atoms, with the proviso that both R and R' are not hydrogen, and with the proviso that when m is equal to 1, and one of R or R.sup.1 is hydrogen the other of R or R.sup.1 is not lower alkoxy of from 1 to 4 carbon atoms; and pharmaceutically acceptable acid addition salts and individual optical isomers where applicable.

Abstract: An aqueous skin cleansing composition is described suitable for use as a non-pressurized, aerated, low-density foam cleanser.

Abstract: Novel 3,6-bis-basic alkanes of carbazole, their preparation and use for the prevention and inhibition of viral infections are disclosed.

Abstract: The method comprises administering to an animal a novel pharmaceutical composition containing a substituted-1-oxo-1H-2-benzothiopyran-3-carboxylic acid to inhibit antigen-antibody reaction in said animal. Representative of the compounds that can be used in the method are:1-Oxo-1H-2-benzothiopyran-3-carboxylic acid, andSodium 6-methoxy-1-oxo-1H-2-benzothiopyran-3-carboxylate.

Abstract: Novel compounds of the following general formula are useful pharmacologic agents: ##EQU1## R is selected from hydrogen, alkylcarbonyl wherein the alkyl moiety contains from 1 to 4 carbon atoms, alkoxycarbonyl wherein the alkoxy moiety contains from 1 to 4 carbon atoms and may be straight or branched, and ##EQU2## wherein R.sub.10 is selected from hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl and p-hydroxybenzyl; R.sub.2 is selected from hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, a lower alkylamino group wherein the alkyl moiety contains from 1 to 4 carbon atoms, and ##EQU3## wherein R.sub.4 is selected from hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl, and p-hydroxybenzyl; R.sub.3 is selected from hydrogen, chlorine, bromine, and iodine; [A] is selected from ##EQU4## AND --CH=CH-- wherein R.sub.

Abstract: Novel compounds of the following general formula are useful pharmacologic agents: ##EQU1## R is selected from hydrogen, alkylcarbonyl wherein the alkyl moiety contains from 1 to 4 carbon atoms, alkoxy-carbonyl wherein the alkoxy moiety contains from 1 to 4 carbon atoms and may be straight or branched, and ##EQU2## wherein R.sub.10 is selected from hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl and p-hydroxybenzyl; R.sub.2 is selected from hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, a lower alkylamino group wherein the alkyl moiety contains from 1 to 4 carbon atoms, and ##EQU3## wherein R.sub.4 is selected from hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl, and p-hydroxybenzyl; [A] is selected from ##EQU4## AND --CH=CH-- wherein R.sub.

Abstract: The novel bis-basic ketones of thioxanthene have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: ##SPC1##Wherein A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y isA. the group ##EQU1## wherein R.sup.1 and R.sup.2 are individually hydrogen or lower alkyl having from 1 to about 4 carbon atoms; orB. the group ##EQU2## WHEREIN N IS A WHOLE INTEGER OF 4 OR 5, AND R.sup.3 is hydrogen or lower alkyl having from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; orC. the group ##EQU3## wherein X is oxygen or NR.sup.4, and R.sup.4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms; or pharmaceutically acceptable acid addition salts of said base.These new compounds can be prepared by several different methods which are described.

Abstract: Novel bis-basic ketones of xanthene and xanthen-9-one have antiviral activity when administered orally and parenterally. The compounds are represented by the following formula: ##SPC1##Wherein Z is oxygen or H.sub.2 ; each A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y isA. the group ##EQU1## wherein R.sup.1 and R.sup.2 are individually hydrogen, lower alkyl having from 1 to about 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; orB. the group ##EQU2## WHEREIN N IS A WHOLE INTEGER FROM 4 TO 6, AND R.sup.3 is hydrogen, lower alkyl of from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; orC. the group ##EQU3## wherein X is oxygen or NR.sup.4, and R.sup.4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms;Or a pharmaceutically acceptable acid addition salt thereof.