Patents Represented by Attorney Evelyn D. Shen

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  • Process for the preparation of substituted tetralin and substituted indane derivatives
    Patent number: 7576238
    Abstract: The present invention relates to novel processes for the preparation of substituted tetralin and substituted indane derivatives. The present invention is further directed to novel processes for the preparation of intermediates in the preparation of the substituted tetralin and substituted indane derivatives.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: August 18, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Fan Zhang-Plasket, Hua Zhong, Frank Villani
  • Substituted indole-O-glucosides
    Patent number: 7129220
    Abstract: Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: October 31, 2006
    Assignee: Janssen Pharmaceutica N.V
    Inventors: Mary Pat Beavers, Mona Patel, Philip Rybczynski, Maud Urbanski, Xiaoyan Zhang
  • Substituted fused heterocyclic C-glycosides
    Patent number: 7094763
    Abstract: This invention relates to substituted fused heterocyclic C-glycosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: August 22, 2006
    Assignee: Janssen Pharaceutica, N.V.
    Inventors: Philip Rybczynski, Maud Urbanski, Xiaoyan Zhang
  • Substituted benzimidazole-, Benztriazole-, and benzimidazolone-O-glucosides
    Patent number: 7094764
    Abstract: This invention relates to to substituted benzimidazole-O-glucosides, benztriazole-O-glucosides, and benzimidazolone-O-glucosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: August 22, 2006
    Assignee: Janssen Pharmaceutica N.V.
    Inventor: Maud Urbanski
  • Substituted indazole-O-glucosides
    Patent number: 7084124
    Abstract: Substituted indazole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: August 1, 2006
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Mona Patel, Philip J. Rybczynski, Maud Urbanski, Xiaoyan Zhang
  • Treatment of asthma with MEK inhibitors
    Patent number: 6696440
    Abstract: This invention provides a method of preventing or treating asthma by administering to a patient in need of treatment an effective amount of a selective MEK inhibitor, especially a phenyl amine of Formula I and II:
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: February 24, 2004
    Assignee: Warner-Lambert Company
    Inventors: Alexander James Bridges, David Thomas Dudley, James Leslie Mobley, Alan Robert Saltiel
  • 4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors
    Patent number: 6506798
    Abstract: The invention provides compounds of formula (II), wherein Ar, R3, R4, R5, R6, R7, R8 and W have the meanings given in the description. They are selective MEK inhibitors.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: January 14, 2003
    Assignee: Warner-Lambert Company
    Inventors: Stephen Barrett, Haile Tecle
  • Benzoheterocycles and their uses as MEK inhibitors
    Patent number: 6469004
    Abstract: The invention provides compounds having formula (I), wherein W is OH, or derivatives of the carboxylic acid, and Q is a heterocyclo-condensed ortho-phenylene residue. These compounds are useful as MEK inhibitors, particularly in the treatment of proliferative diseases such as cancer.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: October 22, 2002
    Assignee: Warner-Lambert Company
    Inventors: Stephen Barrett, Haile Tecle, Alexander J. Bridges
  • Sulohydroxamic acids and sulohyroxamates and their use as MEK inhibitors
    Patent number: 6455582
    Abstract: Sulfohydroxamic acid diarylamines of formula (I), in which the variables are as defined in the claims, are inhibitors of MEK and are effective in the treatment of proliferative diseases, cancer, stroke, heart failure, xenograft rejection, arthritis, cystic fibrosis, hepatomegaly, cardiomegaly, Alzheimer's disease, complications of diabetes, septic shock, and viral infection.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: September 24, 2002
    Assignee: Warner-Lambert Company
    Inventor: Haile Tecle
  • Tricyclic inhibitors of protein farnesyltransferase
    Patent number: 5919780
    Abstract: Compounds of formula I ##STR1## wherein X is N or C--R.sup.9, Y is N--R.sup.10, CH.sub.2, O, S, SO, SO.sub.2, C.dbd.O or CH--OH,R is H or alkyl,R.sup.1 is heteroaryl,n is 1-5, andR.sup.2 -R.sup.10 are H or various substituents,are useful as inhibitors of protein farnesyl transferase and for the treatment of proliferative diseases including cancer, restenosis and psoriasis, and as antiviral agents.
    Type: Grant
    Filed: December 11, 1997
    Date of Patent: July 6, 1999
    Assignee: Warner Lambert Company
    Inventors: Gary L. Bolton, Annette M Doherty, James S. Kaltenbronn, John Quin, III, Jeffrey D. Scholten, Judith Sebolt-Leopold, Harold Zinnes