Abstract: Disclosed is a method of denoising signal mixtures so as to extract a signal of interest, the method comprising receiving a pair of signal mixtures, constructing a time-frequency representation of each mixture, constructing a pair of histograms, one for signal-of-interest segments, the other for non-signal-of-interest segments, combining said histograms to create a weighting matrix, rescaling each time-frequency component of each mixture using said weighting matrix, and resynthesizing the denoised signal from the reweighted time-frequency representations.